NP_001171144.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ovarian cancer G-protein coupled receptor 1
NCBI Official Synonym Full Names
G protein-coupled receptor 68
NCBI Protein Information
ovarian cancer G-protein coupled receptor 1
UniProt Protein Name
Ovarian cancer G-protein coupled receptor 1
UniProt Synonym Protein Names
G-protein coupled receptor 68; Sphingosylphosphorylcholine receptor
UniProt Synonym Gene Names
UniProt Entry Name
OGR1_MOUSE
UniProt Comments for Gpr68
GPR68: Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer. Belongs to the G-protein coupled receptor 1 family.
Protein type: Tumor suppressor; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral
Cellular Component: membrane; plasma membrane; integral to membrane
Molecular Function: G-protein coupled receptor activity; signal transducer activity
Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of insulin secretion; signal transduction; negative regulation of monocyte differentiation
Product References and Citations for anti-Gpr68 antibody
Carninci P., et al. Science 309:1559-1563(2005). Vassilatis D.K., et al. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003). Singh L.S., et al. J. Natl. Cancer Inst. 99:1313-1327(2007). Frick K.K., et al. J. Bone Miner. Res. 24:305-313(2009). Li H., et al. PLoS ONE 4:E5705-E5705(2009).
Research Articles on Gpr68
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Products associated with anti-Gpr68 antibody
Pathways associated with anti-Gpr68 antibody
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Diseases associated with anti-Gpr68 antibody
Organs/Tissues associated with anti-Gpr68 antibody
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