NP_001017426.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
lysine-specific demethylase 6B
NCBI Official Synonym Full Names
KDM1 lysine (K)-specific demethylase 6B
NCBI Official Synonym Symbols
Jmjd3; BC038313; mKIAA0346; 1700064E03Rik [Similar Products]
NCBI Protein Information
lysine-specific demethylase 6B
UniProt Protein Name
Lysine-specific demethylase 6B
UniProt Synonym Protein Names
JmjC domain-containing protein 3; Jumonji domain-containing protein 3
UniProt Synonym Gene Names
UniProt Entry Name
KDM6B_MOUSE
UniProt Comments for Kdm6b
JMJD3: Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Interacts with TLE1. Component of the MLL4 complex, at least composed of MLL4, ASH2L, RBBP5, WDR5, and KDM6B. By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Belongs to the UTX family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.11.-; Oxidoreductase
Cellular Component: nucleus
Molecular Function: procollagen-proline dioxygenase activity; 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity; dioxygenase activity; sulfonate dioxygenase activity; sequence-specific DNA binding; metal ion binding; beta-catenin binding; DNA-N1-methyladenine dioxygenase activity; chromatin binding; oxidoreductase activity
Biological Process: endothelial cell differentiation; histone demethylation; hippocampus development; mesodermal cell differentiation; positive regulation of transcription from RNA polymerase II promoter; chromatin modification; inflammatory response; cardiac muscle cell differentiation
Research Articles on Kdm6b
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Products associated with anti-Kdm6b antibody
Diseases associated with anti-Kdm6b antibody
Organs/Tissues associated with anti-Kdm6b antibody
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