NP_062376.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
phospholemman isoform a
NCBI Official Synonym Full Names
FXYD domain-containing ion transport regulator 1
NCBI Official Synonym Symbols
Plm; Pml; 0610012C17Rik; 1110006M24Rik [Similar Products]
NCBI Protein Information
phospholemman
UniProt Protein Name
Phospholemman
UniProt Synonym Protein Names
FXYD domain-containing ion transport regulator 1
UniProt Synonym Gene Names
UniProt Entry Name
PLM_MOUSE
NCBI Summary for Fxyd1
This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
UniProt Comments for Fxyd1
PLM: a protein of the FXYD family of small ion transport regulators or channels. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May have a functional role in muscle contraction. Major plasma membrane substrate for PKA and PKC in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation.Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining.
Protein type: Cell surface; Channel, misc.; Membrane protein, integral
Cellular Component: membrane; integral to plasma membrane; cell; integral to membrane; plasma membrane; caveola; sarcolemma
Molecular Function: chloride channel activity; sodium channel regulator activity; myosin binding; ion channel activity; ATPase binding
Biological Process: positive regulation of organic acid transport; cytosolic calcium ion homeostasis; transport; ion transport; chloride transport
Research Articles on Fxyd1
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Products associated with anti-Fxyd1 antibody
Pathways associated with anti-Fxyd1 antibody
Diseases associated with anti-Fxyd1 antibody
Organs/Tissues associated with anti-Fxyd1 antibody
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