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anti-SEMA5A antibody :: Rabbit M Sema5a Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9206417
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

M Sema5a, Polyclonal Antibody

★Popular Item★
 Also Known As   

M Sema5a Antibody (N-term)

 Product Synonym Names    Semaphorin-5A; Semaphorin-F; Sema F; SEMA5A; SEMAF
 Product Gene Name   

anti-SEMA5A antibody

[Similar Products]
 Antibody/Peptide Pairs    M Sema5a peptide (MBS9224744) is used for blocking the activity of M Sema5a antibody (MBS9206417)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609297
 3D Structure    ModBase 3D Structure for Q13591
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human, mouse (Predicted Reactivity: Rat)
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 Specificity    This Mouse Sema5a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of mouse Sema5a.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
 Function    Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
 Cellular Location    Membrane; Single-pass type I membrane protein
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-SEMA5A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SEMA5A antibody

   Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development.
 Product Categories/Family for anti-SEMA5A antibody    Neuroscience
 Applications Tested/Suitable for anti-SEMA5A antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-SEMA5A antibody    WB~~1:1000
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 Western Blot (WB) of anti-SEMA5A antibody    Western blot analysis of mouse anti-Sema5a (N-term) Pab in A2058 cell line lysates (35ug/lane). Sema5a(arrow) was detected using the purified Pab.
anti-SEMA5A antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SEMA5A. It may not necessarily be applicable to this product.
 NCBI GI #    147904700
 NCBI GeneID    9037
 NCBI Accession #    NP_003957.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003966.2 [Other Products]
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 UniProt Primary Accession #    Q13591 [Other Products]
 UniProt Secondary Accession #    O60408; Q1RLL9; D3DTC6 [Other Products]
 UniProt Related Accession #    Q13591 [Other Products]
 Molecular Weight    120615
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 NCBI Official Full Name    semaphorin-5A
 NCBI Official Synonym Full Names    sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
 NCBI Official Symbol    SEMA5A [Similar Products]
 NCBI Official Synonym Symbols   
semF; SEMAF
[Similar Products]
 NCBI Protein Information    semaphorin-5A
 UniProt Protein Name    Semaphorin-5A
 UniProt Synonym Protein Names   
Semaphorin-F; Sema F
 Protein Family    Semaphorin
 UniProt Gene Name    SEMA5A [Similar Products]
 UniProt Synonym Gene Names    SEMAF; Sema F [Similar Products]
 UniProt Entry Name    SEM5A_HUMAN
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 NCBI Summary for SEMA5A    This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]
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 UniProt Comments for SEMA5A    SEMA5A: a single-pass type I membrane protein that may act as positive axonal guidance cues.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 5p15.2

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function: syndecan binding; heparan sulfate proteoglycan binding; axon guidance receptor activity; semaphorin receptor binding

Biological Process: nervous system development; axon guidance; positive regulation of actin filament depolymerization; axonal fasciculation; negative regulation of cell adhesion; negative regulation of axon extension involved in axon guidance; diencephalon development; patterning of blood vessels; positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; blood vessel endothelial cell proliferation during sprouting angiogenesis; cell-cell signaling; positive chemotaxis; positive regulation of axon extension involved in axon guidance; positive regulation of endothelial cell proliferation; cell adhesion
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Product References and Citations for anti-SEMA5A antibody

   Bialecka,M., Neurosci. Lett. 399 (1-2), 121-123 (2006)
Melin,M., Neuropsychobiology 54 (1), 64-69 (2006)
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 Research Articles on SEMA5A    1. The Single-Nucleotide Polymorphism (SNP) of rs7702187 within the SEMA5A gene would be a high-penetrant risk factor for PD development.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SEMA5A antibodyPathways associated with anti-SEMA5A antibody
 Reference Product  PubMed Publications
 PLXNB1 antibody  >1 publications with SEMA5A and PLXNB1
 SLIT3 antibody  >1 publications with SEMA5A and SLIT3
 Products by Pathway  Pathway Diagram
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 Mismatch Repair Pathway antibodies  Mismatch Repair Pathway Diagram
 Mismatch Repair Pathway antibodies  Mismatch Repair Pathway Diagram
Diseases associated with anti-SEMA5A antibodyOrgans/Tissues associated with anti-SEMA5A antibody
 Disease Name  Pubmed Publications
 Abnormalities, Multiple Antibodies  >4 publications with SEMA5A and Abnormalities, Multiple
 Congenital Abnormalities Antibodies  >3 publications with SEMA5A and Congenital Abnormalities
 Disease Models, Animal Antibodies  >3 publications with SEMA5A and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >3 publications with SEMA5A and Neurobehavioral Manifestations
 Autistic Disorder Antibodies  >3 publications with SEMA5A and Autistic Disorder
 Cognition Disorders Antibodies  >2 publications with SEMA5A and Cognition Disorders
 Lung Diseases Antibodies  >2 publications with SEMA5A and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with SEMA5A and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >1 publications with SEMA5A and Lung Neoplasms
 Memory Disorders Antibodies  >1 publications with SEMA5A and Memory Disorders
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >42 publications with SEMA5A and Nerve
 Brain Antibodies  >18 publications with SEMA5A and Brain
 Embryonic Tissue Antibodies  >7 publications with SEMA5A and Embryonic Tissue
 Stomach Antibodies  >5 publications with SEMA5A and Stomach
 Eye Antibodies  >5 publications with SEMA5A and Eye
 Blood Antibodies  >4 publications with SEMA5A and Blood
 Lung Antibodies  >3 publications with SEMA5A and Lung
 Bone Antibodies  >2 publications with SEMA5A and Bone
 Muscle Antibodies  >1 publications with SEMA5A and Muscle
 Prostate Antibodies  >1 publications with SEMA5A and Prostate
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