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anti-Tlr4 antibody :: Rabbit anti-Mouse M TLR4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9203360
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

M TLR4, Polyclonal Antibody

 Also Known As   

M TLR4 Antibody (N-term)

 Product Synonym Names    Toll-like receptor 4; CD284; Tlr4; Lps
 Product Gene Name   

anti-Tlr4 antibody

[Similar Products]
 Antibody/Peptide Pairs    M TLR4 peptide (MBS9221306) is used for blocking the activity of M TLR4 antibody (MBS9203360)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    25-55
 3D Structure    ModBase 3D Structure for Q9QUK6
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    This Mouse TLR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 amino acids from the N-terminal region of mouse TLR4.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
 Concentration    Vial Concentration: 2 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    MOUSE
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-Tlr4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Tlr4 antibody

   TLR4, a type I membrane protein that belongs to the Toll-like receptor family, cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). It acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response TLR4 Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR. TLR4 binds to LY96 via the extracellular domain, and to MyD88 and TIRAP via their respective TIR domains. The protein contains 19 leucine-rich (LRR) repeats, and It is highly expressed in heart, spleen, lung and muscle. Lower levels are found in liver and kidney. Interstrain analyses reveal that TLR4 is a polymorphic protein and that the extracellular domain is far more variable than the cytoplasmic domain, which is variable at the C-terminal.
 Product Categories/Family for anti-Tlr4 antibody    Cardiovascular; Immunology; Microbiology; Signal Transduction
 Applications Tested/Suitable for anti-Tlr4 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-Tlr4 antibody    WB~~1:1000
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 Western Blot (WB) of anti-Tlr4 antibody    Western blot analysis of anti-mTLR4 Pab in mouse spleen cell lysate. mTLR4 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
anti-Tlr4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for Tlr4. It may not necessarily be applicable to this product.
 NCBI GI #    10946594
 NCBI GeneID    21898
 NCBI Accession #    NP_067272.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021297.2 [Other Products]
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 UniProt Primary Accession #    Q9QUK6 [Other Products]
 UniProt Secondary Accession #    Q9D691; Q9QZF5; Q9Z203 [Other Products]
 UniProt Related Accession #    Q9QUK6 [Other Products]
 Molecular Weight    95519
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 NCBI Official Full Name    toll-like receptor 4
 NCBI Official Synonym Full Names    toll-like receptor 4
 NCBI Official Symbol    Tlr4 [Similar Products]
 NCBI Official Synonym Symbols   
Lps; Ly87; Ran/M1; Rasl2-8
[Similar Products]
 NCBI Protein Information    toll-like receptor 4
 UniProt Protein Name    Toll-like receptor 4
 UniProt Synonym Protein Names   
CD_antigen: CD284
 Protein Family    Toll-like receptor
 UniProt Gene Name    Tlr4 [Similar Products]
 UniProt Synonym Gene Names    Lps [Similar Products]
 UniProt Entry Name    TLR4_MOUSE
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 NCBI Summary for Tlr4    This gene belongs to the evolutionarily-conserved Toll-like receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracellular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by this gene mediates the innate immune response to bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in this gene display a number of immune response-related phenotypes including hyporesponsiveness to bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls. [provided by RefSeq, Sep 2015]
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 UniProt Comments for Tlr4    TLR4: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS- independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific. Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4. Interacts with CNPY3. Interacts with HSP90B1. The interaction with both CNPY3 and HSP90B1 is required for proper folding in the endoplasmic reticulum. Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells. Belongs to the Toll-like receptor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: cell surface; membrane; perinuclear region of cytoplasm; integral to plasma membrane; cytoplasm; integral to membrane; plasma membrane; lipopolysaccharide receptor complex; lipid raft; external side of plasma membrane

Molecular Function: protein binding; transmembrane receptor activity; lipopolysaccharide binding; lipopolysaccharide receptor activity; phosphoinositide 3-kinase binding; receptor activity

Biological Process: positive regulation of nitric oxide biosynthetic process; activation of MAPK activity; positive regulation of apoptosis; response to lipopolysaccharide; leukotriene metabolic process; positive regulation of NF-kappaB import into nucleus; positive regulation of interleukin-10 production; activation of NF-kappaB transcription factor; negative regulation of interleukin-6 production; positive regulation of B cell proliferation; positive regulation of interferon-beta production; toll-like receptor 4 signaling pathway; positive regulation of interferon-alpha production; positive regulation of DNA binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; production of nitric oxide during acute inflammatory response; positive regulation of interleukin-6 production; positive regulation of interleukin-8 biosynthetic process; positive regulation of tumor necrosis factor production; positive regulation of chemokine production; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of interleukin-23 production; macrophage activation; response to ethanol; response to bacterium; detection of lipopolysaccharide; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; response to oxidative stress; I-kappaB phosphorylation; activation of innate immune response; positive regulation of nitric-oxide synthase biosynthetic process; regulation of cytokine secretion; positive regulation of interleukin-12 production; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK cascade; microglial cell activation; signal transduction; defense response to Gram-negative bacterium; mast cell activation; positive regulation of stress-activated MAPK cascade; positive regulation of interleukin-1 biosynthetic process; positive regulation of interleukin-8 production; positive regulation of lymphocyte proliferation; negative regulation of interferon-gamma production; positive regulation of interleukin-13 biosynthetic process; positive regulation of MHC class II biosynthetic process; interferon-gamma production; lipopolysaccharide-mediated signaling pathway; inflammatory response; innate immune response-activating signal transduction; B cell proliferation during immune response; positive regulation of tumor necrosis factor biosynthetic process; immune system process; activation of NF-kappaB-inducing kinase; negative regulation of tumor necrosis factor production; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interferon-gamma production; positive regulation of interleukin-12 biosynthetic process; negative regulation of interleukin-17 production; positive regulation of interferon-beta biosynthetic process; regulation of inflammatory response; toll-like receptor signaling pathway; innate immune response; immune response; regulation of sensory perception of pain; positive regulation of interleukin-1 production; positive regulation of inflammatory response
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 Research Articles on Tlr4    1. TLR4 inhibition impairs bacterial clearance in a therapeutic setting in murine abdominal sepsis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Tlr4 antibodyPathways associated with anti-Tlr4 antibody
 Reference Product  PubMed Publications
 Myd88 antibody  >1838 publications with Tlr4 and Myd88
 Ly96 antibody  >320 publications with Tlr4 and Ly96
 Traf6 antibody  >204 publications with Tlr4 and Traf6
 Ticam1 antibody  >101 publications with Tlr4 and Ticam1
 Traf3 antibody  >16 publications with Tlr4 and Traf3
 Map3k7 antibody  >5 publications with Tlr4 and Map3k7
 Ikbkg antibody  >5 publications with Tlr4 and Ikbkg
 Birc2 antibody  >1 publications with Tlr4 and Birc2
 Birc3 antibody  >1 publications with Tlr4 and Birc3
 Ube2n antibody  >1 publications with Tlr4 and Ube2n
 Products by Pathway  Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
Diseases associated with anti-Tlr4 antibodyOrgans/Tissues associated with anti-Tlr4 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4273 publications with Tlr4 and Inflammation
 Necrosis Antibodies  >2715 publications with Tlr4 and Necrosis
 Disease Models, Animal Antibodies  >1009 publications with Tlr4 and Disease Models, Animal
 Sepsis Antibodies  >835 publications with Tlr4 and Sepsis
 Liver Diseases Antibodies  >494 publications with Tlr4 and Liver Diseases
 Atherosclerosis Antibodies  >438 publications with Tlr4 and Atherosclerosis
 Lung Injury Antibodies  >327 publications with Tlr4 and Lung Injury
 Heart Diseases Antibodies  >299 publications with Tlr4 and Heart Diseases
 Fibrosis Antibodies  >257 publications with Tlr4 and Fibrosis
 Carcinoma Antibodies  >237 publications with Tlr4 and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1039 publications with Tlr4 and Lung
 Liver Antibodies  >971 publications with Tlr4 and Liver
 Bone Antibodies  >922 publications with Tlr4 and Bone
 Bone Marrow Antibodies  >768 publications with Tlr4 and Bone Marrow
 Brain Antibodies  >673 publications with Tlr4 and Brain
 Kidney Antibodies  >475 publications with Tlr4 and Kidney
 Spleen Antibodies  >465 publications with Tlr4 and Spleen
 Muscle Antibodies  >457 publications with Tlr4 and Muscle
 Heart Antibodies  >430 publications with Tlr4 and Heart
 Skin Antibodies  >275 publications with Tlr4 and Skin
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