NP_001153168.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
transcription factor AP-2 gamma isoform 2
NCBI Official Synonym Full Names
transcription factor AP-2, gamma
NCBI Official Synonym Symbols
Stra2; Ap-2.2; Tcfap2c; AA409384; AP2gamma [Similar Products]
NCBI Protein Information
transcription factor AP-2 gamma
UniProt Protein Name
Transcription factor AP-2 gamma
UniProt Synonym Protein Names
AP-2.2; Activating enhancer-binding protein 2 gamma
UniProt Synonym Gene Names
UniProt Entry Name
AP2C_MOUSE
UniProt Comments for Tfap2c
AP-2 gamma: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. During retinoic acid-mediated differentiation. Belongs to the AP-2 family.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor
Cellular Component: nucleus
Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; skin development; transcription, DNA-dependent; somatic stem cell maintenance; stem cell maintenance; germ-line stem cell maintenance; sebaceous gland development; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic; regulation of cell proliferation; trophectodermal cell differentiation; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; hair follicle development; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; forebrain neuron fate commitment; cell differentiation; regulation of epidermis development
Product References and Citations for anti-Tfap2c antibody
Oulad-Abdelghani M., et al. Exp. Cell Res. 225:338-347(1996). Carninci P., et al. Science 309:1559-1563(2005). Church D.M., et al. PLoS Biol. 7:E1000112-E1000112(2009). Mural R.J., et al. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Yahata T., et al. Genomics 80:601-613(2002).
Research Articles on Tfap2c
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Products associated with anti-Tfap2c antibody
Pathways associated with anti-Tfap2c antibody
Diseases associated with anti-Tfap2c antibody
Organs/Tissues associated with anti-Tfap2c antibody
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