NP_002346.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cation-dependent mannose-6-phosphate receptor isoform 1
NCBI Official Synonym Full Names
mannose-6-phosphate receptor (cation dependent)
NCBI Official Synonym Symbols
SMPR; MPR46; CD-MPR; MPR 46; MPR-46 [Similar Products]
NCBI Protein Information
cation-dependent mannose-6-phosphate receptor
UniProt Protein Name
Cation-dependent mannose-6-phosphate receptor
UniProt Synonym Protein Names
46 kDa mannose 6-phosphate receptor; MPR 46
UniProt Synonym Gene Names
UniProt Entry Name
MPRD_HUMAN
NCBI Summary for M6PR
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
UniProt Comments for M6PR
M6PR: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: membrane; lysosomal membrane; integral to plasma membrane; perinuclear region of cytoplasm; late endosome; endosome
Molecular Function: mannose transmembrane transporter activity; mannose binding; transmembrane receptor activity
Biological Process: receptor-mediated endocytosis; endosome to lysosome transport; signal transduction; mannose transport
Product References and Citations for anti-M6PR antibody
Bosker, F.J., et al. Mol. Psychiatry (2010) In press : Op den Brouw, M.L., et al. Virology 393(1):84-90(2009) Schimanski, L.M., et al. Blood Cells Mol. Dis. 43(2):180-193(2009) Rodriguez-Gabin, A.G., et al. Exp. Cell Res. 315(13):2215-2230(2009) Xaplanteri, P., et al. Eur. J. Immunol. 39(3):730-740(2009)
Research Articles on M6PR
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Products associated with anti-M6PR antibody
Pathways associated with anti-M6PR antibody
Diseases associated with anti-M6PR antibody
Organs/Tissues associated with anti-M6PR antibody
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