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anti-MACC1 antibody :: Rabbit MACC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151243
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MACC1, Polyclonal Antibody

 Also Known As   

MACC1 Antibody

 Product Synonym Names    MACC1; 7A5; SH3BP4L; Metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5; metastasis associated in colon cancer 1
 Product Gene Name   

anti-MACC1 antibody

[Similar Products]
 Antibody/Peptide Pairs    MACC1 peptide (MBS152556) is used for blocking the activity of MACC1 antibody (MBS151243)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    612646
 3D Structure    ModBase 3D Structure for Q6ZN28
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    At least two isoforms of MACC1 are known to exist.
 Purity/Purification    MACC1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    MACC1 antibody was raised against a 17 amino acid synthetic peptide near the center of human MACC1.
 Buffer    MACC1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    MACC1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-MACC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MACC1 antibody

   MACC1 Antibody: Metastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment.
 Applications Tested/Suitable for anti-MACC1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-MACC1 antibody    MACC1 antibody can be used for detection of MACC1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-MACC1 antibody    Western blot analysis of MACC1 in mouse liver tissue lysate with MACC1 antibody at (A) 1 and (B) 2 μg/mL.
anti-MACC1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MACC1 antibody    Immunohistochemistry of MACC1 in human liver tissue with MACC1 antibody at 2.5 μg/mL.
anti-MACC1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-MACC1 antibody    Immunofluorescence of MACC1 in Human Liver cells with MACC1 antibody at 20 μg/mL.
anti-MACC1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for MACC1. It may not necessarily be applicable to this product.
 NCBI GI #    157502191
 NCBI GeneID    346389
 NCBI Accession #    NP_877439 [Other Products]
 NCBI GenBank Nucleotide #    NM_182762.3 [Other Products]
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 UniProt Primary Accession #    Q6ZN28 [Other Products]
 UniProt Secondary Accession #    Q6ZQN8; Q7Z5A5; A8MUS5; B2RNR9 [Other Products]
 UniProt Related Accession #    Q6ZN28 [Other Products]
 Molecular Weight    Predicted: 94 kDa

Observed: 90 kDa
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 NCBI Official Full Name    metastasis-associated in colon cancer protein 1
 NCBI Official Synonym Full Names    metastasis associated in colon cancer 1
 NCBI Official Symbol    MACC1 [Similar Products]
 NCBI Official Synonym Symbols   
7A5; SH3BP4L
[Similar Products]
 NCBI Protein Information    metastasis-associated in colon cancer protein 1; putative binding protein 7a5; SH3 domain-containing protein 7a5
 UniProt Protein Name    Metastasis-associated in colon cancer protein 1
 UniProt Synonym Protein Names   
SH3 domain-containing protein 7a5
 Protein Family    Metastasis-associated in colon cancer protein
 UniProt Gene Name    MACC1 [Similar Products]
 UniProt Entry Name    MACC1_HUMAN
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 NCBI Summary for MACC1    MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]
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 UniProt Comments for MACC1    MACC1: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.

Chromosomal Location of Human Ortholog: 7p21.1

Cellular Component: cytoplasm; nucleus

Molecular Function: growth factor activity

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of cell division
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 Research Articles on MACC1    1. Highly expressed MACC1 protein is associated with hepatocellular carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MACC1 antibodyDiseases associated with anti-MACC1 antibody
 Reference Product  PubMed Publications
 MET antibody  >40 publications with MACC1 and MET
 HGF antibody  >15 publications with MACC1 and HGF
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >17 publications with MACC1 and Adenocarcinoma
 Lung Diseases Antibodies  >5 publications with MACC1 and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >3 publications with MACC1 and Cell Transformation, Neoplastic
 Ovarian Neoplasms Antibodies  >3 publications with MACC1 and Ovarian Neoplasms
 Ovarian Diseases Antibodies  >3 publications with MACC1 and Ovarian Diseases
 Inflammation Antibodies  >2 publications with MACC1 and Inflammation
 Postoperative Complications Antibodies  >1 publications with MACC1 and Postoperative Complications
 Breast Neoplasms Antibodies  >1 publications with MACC1 and Breast Neoplasms
 Disease Models, Animal Antibodies  >1 publications with MACC1 and Disease Models, Animal
 Necrosis Antibodies  >1 publications with MACC1 and Necrosis
Organs/Tissues associated with anti-MACC1 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >16 publications with MACC1 and Liver
 Lymph Node Antibodies  >13 publications with MACC1 and Lymph Node
 Lung Antibodies  >7 publications with MACC1 and Lung
 Stomach Antibodies  >4 publications with MACC1 and Stomach
 Brain Antibodies  >2 publications with MACC1 and Brain
 Ovary Antibodies  >1 publications with MACC1 and Ovary
 Embryonic Tissue Antibodies  >1 publications with MACC1 and Embryonic Tissue
 Kidney Antibodies  >1 publications with MACC1 and Kidney
 Intestine Antibodies  >1 publications with MACC1 and Intestine
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