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anti-MAD1L1 antibody :: Rabbit MAD1L1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2526289
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAD1L1, Polyclonal Antibody

 Also Known As   

MAD1L1 Polyclonal Antibody

 Product Synonym Names    MAD1; PIG9; TP53I9; TXBP181
 Product Gene Name   

anti-MAD1L1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602686
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1mg/mL (lot specific)
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 Immunogen    Recombinant protein of human MAD1L1
 Calculated Molecular Weight: 83kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-MAD1L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MAD1L1 antibody

   MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene.
 Applications Tested/Suitable for anti-MAD1L1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-MAD1L1 antibody    WB: 1:500-1:2000
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 Western Blot (WB) of anti-MAD1L1 antibody    Western blot analysis of Hela, 231, hepG2 and Raji cell, using MAD1L1 Polyclonal Antibody at dilution of 1:500
anti-MAD1L1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MAD1L1. It may not necessarily be applicable to this product.
 NCBI GI #    751557640
 NCBI GeneID    8379
 NCBI Accession #    NP_001291454.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001304525.1 [Other Products]
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 UniProt Secondary Accession #    Q13312; Q75MI0; Q86UM4; Q9UNH0; B3KR41 [Other Products]
 UniProt Related Accession #    Q9Y6D9 [Other Products]
 Molecular Weight    72,286 Da
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 NCBI Official Full Name    mitotic spindle assembly checkpoint protein MAD1 isoform c
 NCBI Official Synonym Full Names    MAD1 mitotic arrest deficient-like 1 (yeast)
 NCBI Official Symbol    MAD1L1 [Similar Products]
 NCBI Official Synonym Symbols   
MAD1; PIG9; TP53I9; TXBP181
[Similar Products]
 NCBI Protein Information    mitotic spindle assembly checkpoint protein MAD1; MAD1-like protein 1; mitotic arrest deficient 1-like protein 1; mitotic checkpoint MAD1 protein homolog; mitotic-arrest deficient 1, yeast, homolog-like 1; tax-binding protein 181; tumor protein p53 inducible protein 9
 UniProt Protein Name    Mitotic spindle assembly checkpoint protein MAD1
 UniProt Synonym Protein Names   
Mitotic arrest deficient 1-like protein 1; MAD1-like protein 1; Mitotic checkpoint MAD1 protein homolog; HsMAD1; hMAD1; Tax-binding protein 181
 Protein Family    Mitotic spindle assembly checkpoint protein
 UniProt Gene Name    MAD1L1 [Similar Products]
 UniProt Synonym Gene Names    MAD1; TXBP181; MAD1-like protein 1; HsMAD1; hMAD1 [Similar Products]
 UniProt Entry Name    MD1L1_HUMAN
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 NCBI Summary for MAD1L1    MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
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 UniProt Comments for MAD1L1    MAD1L1: a component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Expressed weakly at G0/G1 and highly at late S and G2/M phase. Induced by p53. Becomes hyperphosphorylated in late S through M phases or after mitotic spindle damage. Two alternatively spliced isoforms have been described. Defects in MAD1L1 are involved in the development and/or progression of various types of cancer.

Protein type: Cell cycle regulation; Cytoskeletal

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: kinetochore; centrosome; cytoplasm; nuclear pore; spindle; nucleus; cytosol; actin cytoskeleton

Molecular Function: protein binding

Biological Process: mitosis; cell division; mitotic cell cycle checkpoint; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle

Disease: Prostate Cancer
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 Research Articles on MAD1L1    1. Mad1 is required for mitotic arrest even when C-Mad2 is artificially recruited to kinetochores. The C-terminal globular domain of Mad1 and conserved residues in this region are required for this unexpected function of Mad1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAD1L1 antibodyPathways associated with anti-MAD1L1 antibody
 Reference Product  PubMed Publications
 MAD2L1 antibody  >55 publications with MAD1L1 and MAD2L1
 CDC20 antibody  >29 publications with MAD1L1 and CDC20
 BUB3 antibody  >14 publications with MAD1L1 and BUB3
 TTK antibody  >12 publications with MAD1L1 and TTK
 NDC80 antibody  >4 publications with MAD1L1 and NDC80
 BUB1B antibody  >4 publications with MAD1L1 and BUB1B
 AURKB antibody  >3 publications with MAD1L1 and AURKB
 ZW10 antibody  >1 publications with MAD1L1 and ZW10
 Products by Pathway  Pathway Diagram
 Amplification Of Signal From Unattached Kinetochores Via A MAD2 Inhibitory Signal Pathway antibodies  Amplification Of Signal From Unattached Kinetochores Via A MAD2 Inhibitory Signal Pathway Diagram
 Amplification Of Signal From The Kinetochores Pathway antibodies  Amplification Of Signal From The Kinetochores Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
Diseases associated with anti-MAD1L1 antibodyOrgans/Tissues associated with anti-MAD1L1 antibody
 Disease Name  Pubmed Publications
 Leukemia Antibodies  >14 publications with MAD1L1 and Leukemia
 Adenocarcinoma Antibodies  >8 publications with MAD1L1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >6 publications with MAD1L1 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >6 publications with MAD1L1 and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >6 publications with MAD1L1 and Lung Neoplasms
 Necrosis Antibodies  >4 publications with MAD1L1 and Necrosis
 Liver Diseases Antibodies  >4 publications with MAD1L1 and Liver Diseases
 Liver Neoplasms Antibodies  >3 publications with MAD1L1 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with MAD1L1 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >3 publications with MAD1L1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >17 publications with MAD1L1 and Blood
 Bone Antibodies  >9 publications with MAD1L1 and Bone
 Lung Antibodies  >8 publications with MAD1L1 and Lung
 Bone Marrow Antibodies  >6 publications with MAD1L1 and Bone Marrow
 Stomach Antibodies  >5 publications with MAD1L1 and Stomach
 Liver Antibodies  >4 publications with MAD1L1 and Liver
 Skin Antibodies  >4 publications with MAD1L1 and Skin
 Thymus Antibodies  >2 publications with MAD1L1 and Thymus
 Kidney Antibodies  >2 publications with MAD1L1 and Kidney
 Heart Antibodies  >2 publications with MAD1L1 and Heart
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