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anti-MADCAM1 antibody :: Rabbit anti-Human MADCAM1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS126744 anti-MADCAM1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MADCAM1, Polyclonal Antibody

 Also Known As   

MADCAM1

 Product Gene Name   

anti-MADCAM1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    102670
 3D Structure    ModBase 3D Structure for Q13477
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Species    Human
 Route    Synthetic Peptide
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 Other Notes    Small volumes of anti-MADCAM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-MADCAM1 antibody    Polyclonal
 Applications Tested/Suitable for anti-MADCAM1 antibody   

Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for MADCAM1. It may not necessarily be applicable to this product.
 NCBI GI #    218511712
 NCBI GeneID    8174
 NCBI Accession #    Q13477.2 [Other Products]
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 UniProt Primary Accession #    Q13477 [Other Products]
 UniProt Secondary Accession #    O60222; O75867; Q5UGI7; A5PKV4; B2RPL9 [Other Products]
 UniProt Related Accession #    Q13477 [Other Products]
 Molecular Weight    382
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 NCBI Official Full Name    Mucosal addressin cell adhesion molecule 1
 NCBI Official Synonym Full Names    mucosal vascular addressin cell adhesion molecule 1
 NCBI Official Symbol    MADCAM1 [Similar Products]
 NCBI Official Synonym Symbols   
MACAM1
[Similar Products]
 NCBI Protein Information    mucosal addressin cell adhesion molecule 1; MAdCAM-1; hMAdCAM-1; mucosal addressin cell adhesion molecule-1
 UniProt Protein Name    Mucosal addressin cell adhesion molecule 1
 Protein Family    Mucosal addressin cell adhesion molecule
 UniProt Gene Name    MADCAM1 [Similar Products]
 UniProt Synonym Gene Names    MAdCAM-1; hMAdCAM-1 [Similar Products]
 UniProt Entry Name    MADCA_HUMAN
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 NCBI Summary for MADCAM1    The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MADCAM1    MADCAM1: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: membrane; integral to membrane; plasma membrane

Biological Process: integrin-mediated signaling pathway; regulation of immune response; extracellular matrix organization and biogenesis; positive regulation of leukocyte migration; cell-matrix adhesion; signal transduction; receptor clustering; keratinocyte differentiation; heterotypic cell-cell adhesion; immune response; leukocyte tethering or rolling; cell adhesion; aging
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 Research Articles on MADCAM1    1. MADCAM1 is up-regulated in liver cirrhosis with expression on peribiliary vascular plexus and lymphoid aggregates
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MADCAM1 antibodyPathways associated with anti-MADCAM1 antibody
 Reference Product  PubMed Publications
 ITGA4 antibody  >49 publications with MADCAM1 and ITGA4
 CCL25 antibody  >9 publications with MADCAM1 and CCL25
 CD44 antibody  >5 publications with MADCAM1 and CD44
 LTBR antibody  >4 publications with MADCAM1 and LTBR
 NKX2-3 antibody  >3 publications with MADCAM1 and NKX2-3
 CXCR4 antibody  >2 publications with MADCAM1 and CXCR4
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Paxillin-independent Events Mediated By A4b1 And A4b7 Pathway antibodies  Paxillin-independent Events Mediated By A4b1 And A4b7 Pathway Diagram
Diseases associated with anti-MADCAM1 antibodyOrgans/Tissues associated with anti-MADCAM1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >84 publications with MADCAM1 and Inflammation
 Necrosis Antibodies  >48 publications with MADCAM1 and Necrosis
 Colitis Antibodies  >47 publications with MADCAM1 and Colitis
 Inflammatory Bowel Diseases Antibodies  >41 publications with MADCAM1 and Inflammatory Bowel Diseases
 Vascular Diseases Antibodies  >33 publications with MADCAM1 and Vascular Diseases
 Lymphoma Antibodies  >29 publications with MADCAM1 and Lymphoma
 Autoimmune Diseases Antibodies  >25 publications with MADCAM1 and Autoimmune Diseases
 Liver Diseases Antibodies  >14 publications with MADCAM1 and Liver Diseases
 Pancreatitis Antibodies  >4 publications with MADCAM1 and Pancreatitis
 Atrophy Antibodies  >3 publications with MADCAM1 and Atrophy
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >47 publications with MADCAM1 and Spleen
 Brain Antibodies  >13 publications with MADCAM1 and Brain
 Heart Antibodies  >5 publications with MADCAM1 and Heart
 Testis Antibodies  >2 publications with MADCAM1 and Testis
 Eye Antibodies  >1 publications with MADCAM1 and Eye
 Thyroid Antibodies  >1 publications with MADCAM1 and Thyroid
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