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anti-MAGEA2 antibody :: Rabbit anti-Human MAGEA2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS126898 anti-MAGEA2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAGEA2, Polyclonal Antibody

 Also Known As   

MAGEA2

 Product Gene Name   

anti-MAGEA2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 300549
 3D Structure    ModBase 3D Structure for P43356
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Species    Human
 Route    Synthetic Peptide
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 Other Notes    Small volumes of anti-MAGEA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-MAGEA2 antibody    Polyclonal
 Applications Tested/Suitable for anti-MAGEA2 antibody   

Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for MAGEA2. It may not necessarily be applicable to this product.
 NCBI GI #    1170856
 NCBI GeneID    266740
 NCBI Accession #    P43356.1 [Other Products]
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 UniProt Primary Accession #    P43356 [Other Products]
 UniProt Secondary Accession #    Q32NC6; A8K328 [Other Products]
 UniProt Related Accession #    P43356 [Other Products]
 Molecular Weight    314
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 NCBI Official Full Name    Melanoma-associated antigen 2
 NCBI Official Synonym Full Names    melanoma antigen family A, 2B
 NCBI Official Symbol    MAGEA2B [Similar Products]
 NCBI Official Synonym Symbols   
MAGE2; MAGEA2
[Similar Products]
 NCBI Protein Information    melanoma-associated antigen 2; CT1.2; MAGE-2 antigen; melanoma antigen 2; cancer/testis antigen 1.2; melanoma antigen, family A, 2, copy b
 UniProt Protein Name    Melanoma-associated antigen 2
 UniProt Synonym Protein Names   
Cancer/testis antigen 1.2; CT1.2; MAGE-2 antigen
 Protein Family    Melanoma-associated antigen
 UniProt Gene Name    MAGEA2 [Similar Products]
 UniProt Synonym Gene Names    MAGE2; MAGEA2A; CT1.2 [Similar Products]
 UniProt Entry Name    MAGA2_HUMAN
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 NCBI Summary for MAGEA2    This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MAGEA2    MAGE-A2: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T- lymphocytes.

Protein type: Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: PML body; nucleus

Molecular Function: protein binding; histone deacetylase binding; ubiquitin protein ligase binding

Biological Process: transcription, DNA-dependent; cellular protein catabolic process; positive regulation of ubiquitin-protein ligase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of protein sumoylation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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