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anti-MAGI3 antibody :: Rabbit anti-Human MAGI3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9215751
Western Blot (WB)
Unit / Price
0.05 mL  /  $150 +1 FREE 8GB USB
0.2 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAGI3, Polyclonal Antibody

★Popular Item★
 Also Known As   

MAGI3 Antibody (C-Term)

 Product Synonym Names    Purified Rabbit Polyclonal Antibody (Pab); Membrane-associated guanylate kinase; WW and PDZ domain-containing protein 3; Membrane-associated guanylate kinase inverted 3; MAGI-3; MAGI3; KIAA1634
 Product Gene Name   

anti-MAGI3 antibody

[Similar Products]
 Antibody/Peptide Pairs    MAGI3 peptide (MBS9230462) is used for blocking the activity of MAGI3 antibody (MBS9215751)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    615943
 3D Structure    ModBase 3D Structure for Q5TCQ9
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 Clonality    Polyclonal
 Isotype    Ig
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This MAGI3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1330-1360 amino acids from human MAGI3.
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Antigen Source    Human
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-MAGI3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MAGI3 antibody

   Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
 Product Categories/Family for anti-MAGI3 antibody    Signal Transduction
 Applications Tested/Suitable for anti-MAGI3 antibody   

Western Blot (WB)

 Application Notes for anti-MAGI3 antibody    WB ~~ 1:2000
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 Western Blot (WB) of anti-MAGI3 antibody    Anti-MAGI3 Antibody (C-Term) at 1:2000 dilution + human brain lysate

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 166 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.
anti-MAGI3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MAGI3. It may not necessarily be applicable to this product.
 NCBI GI #    218505835
 NCBI GeneID    260425
 NCBI Accession #    NP_001136254.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001142782.1 [Other Products]
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 UniProt Primary Accession #    Q5TCQ9 [Other Products]
 UniProt Secondary Accession #    Q5TCQ8; Q5TCR0; Q9H2V6; Q9H5Y8; Q9HBC4; Q9HCD8 [Other Products]
 UniProt Related Accession #    Q5TCQ9 [Other Products]
 Molecular Weight    165608
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 NCBI Official Full Name    membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform 1
 NCBI Official Synonym Full Names    membrane associated guanylate kinase, WW and PDZ domain containing 3
 NCBI Official Symbol    MAGI3 [Similar Products]
 NCBI Official Synonym Symbols   
MAGI-3; dJ730K3.2
[Similar Products]
 NCBI Protein Information    membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
 UniProt Protein Name    Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
 UniProt Synonym Protein Names   
Membrane-associated guanylate kinase inverted 3; MAGI-3
 Protein Family    Membrane-associated guanylate kinase, WW and PDZ domain-containing protein
 UniProt Gene Name    MAGI3 [Similar Products]
 UniProt Synonym Gene Names    KIAA1634; MAGI-3 [Similar Products]
 UniProt Entry Name    MAGI3_HUMAN
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 NCBI Summary for MAGI3    MAGI3: a protein of the MAGUK family of proteins. A peripheral membrane protein found at cell-cell junctions. Contains one guanylate kinase, two WW, and four PDZ domains. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. Interacts with ADRB1, FZD4, FZD7, PTPRB, TGFA and VANGL2. Interacts with BAI1, LPAR2/EDG4, GRIN2B and PTEN. In case of infection, interacts with HTLV TAX1 protein, possibly affecting the transformation ability of TAX1. Does not interact with HTLV TAX2 or TAX3 proteins. Interacts with HPV type 16 and HPV type 18 E6 protein. Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex. Four alternatively spliced human isoforms have been described.

Protein type: Membrane protein, peripheral; Kinase, other

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: tight junction; membrane; plasma membrane; nucleus

Molecular Function: guanylate kinase activity; protein binding; frizzled binding; protein complex scaffold; ATP binding

Biological Process: positive regulation of JNK activity; viral reproduction; apoptosis; GDP metabolic process; GMP metabolic process
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 UniProt Comments for MAGI3    MAGI3: a protein of the MAGUK family of proteins. A peripheral membrane protein found at cell-cell junctions. Contains one guanylate kinase, two WW, and four PDZ domains. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. Interacts with ADRB1, FZD4, FZD7, PTPRB, TGFA and VANGL2. Interacts with BAI1, LPAR2/EDG4, GRIN2B and PTEN. In case of infection, interacts with HTLV TAX1 protein, possibly affecting the transformation ability of TAX1. Does not interact with HTLV TAX2 or TAX3 proteins. Interacts with HPV type 16 and HPV type 18 E6 protein. Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex. Four alternatively spliced human isoforms have been described.

Protein type: Kinase, other; Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: membrane; nucleus; plasma membrane; tight junction

Molecular Function: ATP binding; frizzled binding; guanylate kinase activity; protein binding; protein complex scaffold

Biological Process: apoptosis; GDP metabolic process; GMP metabolic process; positive regulation of JNK activity; viral reproduction
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Product References and Citations for anti-MAGI3 antibody

   Wu Y.,et al.J. Biol. Chem. 275:21477-21485(2000). Franklin J.L.,et al.Exp. Cell Res. 303:457-470(2005). Gregory S.G.,et al.Nature 441:315-321(2006). Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Nagase T.,et al.DNA Res. 7:273-281(2000).
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 Research Articles on MAGI3    1. MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAGI3 antibodyPathways associated with anti-MAGI3 antibody
 Reference Product  PubMed Publications
 PTEN antibody  >5 publications with MAGI3 and PTEN
 CTNNB1 antibody  >2 publications with MAGI3 and CTNNB1
 VANGL2 antibody  >2 publications with MAGI3 and VANGL2
 Products by Pathway  Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
Diseases associated with anti-MAGI3 antibodyOrgans/Tissues associated with anti-MAGI3 antibody
 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >2 publications with MAGI3 and Autoimmune Diseases
 Adenocarcinoma Antibodies  >1 publications with MAGI3 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >1 publications with MAGI3 and Cell Transformation, Neoplastic
 Carcinoma, Hepatocellular Antibodies  >1 publications with MAGI3 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >2 publications with MAGI3 and Thyroid
 Lung Antibodies  >2 publications with MAGI3 and Lung
 Brain Antibodies  >2 publications with MAGI3 and Brain
 Vascular Antibodies  >1 publications with MAGI3 and Vascular
 Bone Antibodies  >1 publications with MAGI3 and Bone
 Eye Antibodies  >1 publications with MAGI3 and Eye
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