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anti-MALT1 antibody :: Rabbit MALT1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9403979
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MALT1, Polyclonal Antibody

★Popular Item★
 Also Known As   

MALT1 antibody

 Product Synonym Names    DKFZp434L132; MLT; MLT1
 Product Gene Name   

anti-MALT1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604860
 3D Structure    ModBase 3D Structure for Q9UDY8
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    The antibody detects endogenous level of total MALT1 antibody.
 Purity/Purification    Antibodies were purified by affinity purification using immunogen.
 Form/Format    Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen Type    Recombinant Protein
 Immunogen Description    Recombinant protein of human MALT1.
 Target Name    MALT1
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-MALT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MALT1 antibody

   Mucosa-associated lymphoid tissue translocation gene 1 (MALT1) is a paracaspase that is a critical mediator of T-cell receptor activation of NF-kB and may contribute to the progression of MALT lymphomas (1-4). It contains two immunoglobulin-like domains, an amino-terminal death domain and a carboxy-terminal caspase-like domain. Association of MALT1 with Bcl-10 and CARD11/Carma1 leads to activation of IKK and subsequent stimulation of NF-kB, resulting in increased proliferation and inhibition of apoptosis (5,6). A common translocation in MALT B-cell non-Hodgkin lymphomas t(11;18)(q21;q21) results in the fusion of the amino terminus of API2 (c-IAP2), a member of the inhibitor of apoptosis protein family, to the carboxy terminus of MALT1 (1,2). The API2-MALT1 fusion protein likely leads to deregulation of NF-kB, contributing to increased oncogenic potential (7).
 Product Categories/Family for anti-MALT1 antibody    Total protein Ab
 Applications Tested/Suitable for anti-MALT1 antibody   

Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-MALT1 antibody    Western blotting: 1:500 - 1:2000
Immunofluorescence: 1:50 - 1:200
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 Western Blot (WB) of anti-MALT1 antibody    Western blot analysis of extracts of various cell lines, using MALT1 antibody.
anti-MALT1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-MALT1 antibody    Immunofluorescence analysis of U20S cell using MALT1 antibody. Blue: DAPI for nuclear staining.
anti-MALT1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for MALT1. It may not necessarily be applicable to this product.
 NCBI GI #    5803078
 NCBI GeneID    10892
 NCBI Accession #    NP_006776.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006785.3 [Other Products]
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 UniProt Primary Accession #    Q9UDY8 [Other Products]
 UniProt Secondary Accession #    Q9NTB7; Q9ULX4 [Other Products]
 UniProt Related Accession #    Q9UDY8 [Other Products]
 Molecular Weight    92kd
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 NCBI Official Full Name    mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform a
 NCBI Official Synonym Full Names    MALT1 paracaspase
 NCBI Official Symbol    MALT1 [Similar Products]
 NCBI Official Synonym Symbols   
MLT; MLT1; IMD12
[Similar Products]
 NCBI Protein Information    mucosa-associated lymphoid tissue lymphoma translocation protein 1
 UniProt Protein Name    Mucosa-associated lymphoid tissue lymphoma translocation protein 1
 UniProt Synonym Protein Names   
MALT lymphoma-associated translocation; Paracaspase
 Protein Family    Mucosa-associated lymphoid tissue lymphoma translocation protein
 UniProt Gene Name    MALT1 [Similar Products]
 UniProt Synonym Gene Names    MLT [Similar Products]
 UniProt Entry Name    MALT1_HUMAN
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 NCBI Summary for MALT1    This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MALT1    MALT1: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6. Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. Belongs to the peptidase C14B family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Ligase; Protease; Apoptosis; Nuclear export; Adaptor/scaffold; EC 3.4.22.-

Chromosomal Location of Human Ortholog: 18q21

Cellular Component: CBM complex; protein complex; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nucleolus; nucleus; cytosol

Molecular Function: peptidase activity; protein binding; signal transducer activity; protein self-association; protease binding; cysteine-type endopeptidase activity; ubiquitin-protein ligase activity; kinase activator activity

Biological Process: response to fungus; positive regulation of I-kappaB kinase/NF-kappaB cascade; activation of NF-kappaB-inducing kinase; nuclear export; positive regulation of T cell cytokine production; protein ubiquitination; defense response; proteolysis; T cell receptor signaling pathway; protein oligomerization; activation of NF-kappaB transcription factor; T cell proliferation; regulation of apoptosis; B-1 B cell differentiation; positive regulation of protein ubiquitination; response to molecule of bacterial origin; regulation of T cell receptor signaling pathway; positive regulation of interleukin-2 production; innate immune response; positive regulation of T cell activation; negative regulation of apoptosis

Disease: Immunodeficiency 12
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 Research Articles on MALT1    1. Absence of the carcinoma cell-specific mutation suggests that the inactivation of MALT1 expression but not the mutation promotes oral carcinoma progression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MALT1 antibodyPathways associated with anti-MALT1 antibody
 Reference Product  PubMed Publications
 BCL10 antibody  >233 publications with MALT1 and BCL10
 CARD11 antibody  >79 publications with MALT1 and CARD11
 IKBKB antibody  >39 publications with MALT1 and IKBKB
 TRAF6 antibody  >19 publications with MALT1 and TRAF6
 CARD10 antibody  >13 publications with MALT1 and CARD10
 PRKCQ antibody  >11 publications with MALT1 and PRKCQ
 TAB2 antibody  >1 publications with MALT1 and TAB2
 NFKBIA antibody  >1 publications with MALT1 and NFKBIA
 UBE2N antibody  >1 publications with MALT1 and UBE2N
 Products by Pathway  Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 C-type Lectin Receptors (CLRs) Pathway antibodies  C-type Lectin Receptors (CLRs) Pathway Diagram
 CLEC7A (Dectin-1) Signaling Pathway antibodies  CLEC7A (Dectin-1) Signaling Pathway Diagram
 CLEC7A/inflammasome Pathway antibodies  CLEC7A/inflammasome Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
Diseases associated with anti-MALT1 antibodyOrgans/Tissues associated with anti-MALT1 antibody
 Disease Name  Pubmed Publications
 Lymphoma, Large B-Cell, Diffuse Antibodies  >86 publications with MALT1 and Lymphoma, Large B-Cell, Diffuse
 Inflammation Antibodies  >44 publications with MALT1 and Inflammation
 Autoimmune Diseases Antibodies  >29 publications with MALT1 and Autoimmune Diseases
 Lung Neoplasms Antibodies  >25 publications with MALT1 and Lung Neoplasms
 Necrosis Antibodies  >24 publications with MALT1 and Necrosis
 Skin Diseases Antibodies  >22 publications with MALT1 and Skin Diseases
 Lung Diseases Antibodies  >22 publications with MALT1 and Lung Diseases
 Death Antibodies  >20 publications with MALT1 and Death
 Skin Neoplasms Antibodies  >16 publications with MALT1 and Skin Neoplasms
 Cell Transformation, Neoplastic Antibodies  >15 publications with MALT1 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >142 publications with MALT1 and Blood
 Stomach Antibodies  >91 publications with MALT1 and Stomach
 Lung Antibodies  >43 publications with MALT1 and Lung
 Intestine Antibodies  >20 publications with MALT1 and Intestine
 Lymph Node Antibodies  >19 publications with MALT1 and Lymph Node
 Bone Antibodies  >15 publications with MALT1 and Bone
 Liver Antibodies  >14 publications with MALT1 and Liver
 Eye Antibodies  >13 publications with MALT1 and Eye
 Mouth Antibodies  >9 publications with MALT1 and Mouth
 Thymus Antibodies  >9 publications with MALT1 and Thymus
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