NP_055572.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
108,054 Da
NCBI Official Full Name
mastermind-like protein 1
NCBI Official Synonym Full Names
mastermind-like 1 (Drosophila)
NCBI Official Synonym Symbols
NCBI Protein Information
mastermind-like protein 1; MAML1; mastermind homolog
UniProt Protein Name
Mastermind-like protein 1
UniProt Synonym Gene Names
UniProt Entry Name
MAML1_HUMAN
NCBI Summary for MAML1
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]
UniProt Comments for MAML1
MAML1: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8. Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. Belongs to the mastermind family.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 5q35
Cellular Component: nucleoplasm; intracellular membrane-bound organelle; nuclear speck; nucleus
Molecular Function: protein binding; peptide antigen binding; transcription coactivator activity; protein kinase binding
Biological Process: myoblast differentiation; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; activation of Notch receptor target transcription factor
Research Articles on MAML1
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Products associated with anti-MAML1 antibody
Pathways associated with anti-MAML1 antibody
Diseases associated with anti-MAML1 antibody
Organs/Tissues associated with anti-MAML1 antibody
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