NP_002363.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
131,141 Da
NCBI Official Full Name
alpha-mannosidase 2
NCBI Official Synonym Full Names
mannosidase alpha class 2A member 1
NCBI Protein Information
alpha-mannosidase 2
UniProt Protein Name
Alpha-mannosidase 2
UniProt Synonym Protein Names
Golgi alpha-mannosidase II; AMan II; Man II; Mannosidase alpha class 2A member 1; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
UniProt Synonym Gene Names
UniProt Entry Name
MA2A1_HUMAN
NCBI Summary for MAN2A1
This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]
UniProt Comments for MAN2A1
MAN2A1: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. Belongs to the glycosyl hydrolase 38 family.
Protein type: Glycan Metabolism - N-glycan biosynthesis; EC 3.2.1.114; Hydrolase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q21.3
Cellular Component: cis-Golgi network; Golgi membrane; integral to membrane; membrane
Molecular Function: carbohydrate binding; hydrolase activity, hydrolyzing N-glycosyl compounds; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity; zinc ion binding
Biological Process: alveolus development; in utero embryonic development; liver development; mannose metabolic process; mitochondrion organization and biogenesis; N-glycan processing; positive regulation of neurogenesis; protein deglycosylation; respiratory gaseous exchange; retina morphogenesis in camera-type eye; vacuole organization and biogenesis
Research Articles on MAN2A1
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Pathways associated with anti-MAN2A1 antibody
Diseases associated with anti-MAN2A1 antibody
Organs/Tissues associated with anti-MAN2A1 antibody
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