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anti-MAN2A1 antibody :: Rabbit anti-Human MAN2A1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7052761
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAN2A1, Polyclonal Antibody

★Popular Item★
 Also Known As   

MAN2A1 Antibody

 Product Synonym Names    Alpha-mannosidase 2; Golgi alpha-mannosidase II; AMan II; Man II; Mannosidase alpha class 2A member 1; Mannosyl-oligosaccharide 1; 3-1; 6-alpha-mannosidase; MAN2A1; MANA2
 Product Gene Name   

anti-MAN2A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    U31520 mRNA
 3D Structure    ModBase 3D Structure for Q16706
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Alpha-mannosidase 2 protein (31-181AA)
 Conjugation    Non-conjugated
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MAN2A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MAN2A1 antibody

   Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
 Applications Tested/Suitable for anti-MAN2A1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-MAN2A1 antibody    WB: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:50-1:200
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 Western Blot (WB) of anti-MAN2A1 antibody    Western Blot
Positive WB detected in: HEK293 whole cell lysate,HepG2 whole cell lysate
All lanes: MAN2A1 antibody at 3.5ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 132 KDa
Observed band size: 150 KDa

anti-MAN2A1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MAN2A1 antibody    Immunohistochemistry of paraffin-embedded human lung cancer using MBS7052761 at dilution of 1:100
anti-MAN2A1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-MAN2A1 antibody    Immunohistochemistry of paraffin-embedded human cervical cancer using MBS7052761 at dilution of 1:100
anti-MAN2A1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-MAN2A1 antibody    Immunofluorescent analysis of Hela cells using MBS7052761 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-MAN2A1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for MAN2A1. It may not necessarily be applicable to this product.
 NCBI GI #    51477714
 NCBI GeneID    4124
 NCBI Accession #    NP_002363.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002372.3 [Other Products]
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 UniProt Primary Accession #    Q16706 [Other Products]
 UniProt Secondary Accession #    Q16767 [Other Products]
 UniProt Related Accession #    Q16706 [Other Products]
 Molecular Weight    131,141 Da
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 NCBI Official Full Name    alpha-mannosidase 2
 NCBI Official Synonym Full Names    mannosidase alpha class 2A member 1
 NCBI Official Symbol    MAN2A1 [Similar Products]
 NCBI Official Synonym Symbols   
MANA2; MANII; GOLIM7; AMan II
[Similar Products]
 NCBI Protein Information    alpha-mannosidase 2
 UniProt Protein Name    Alpha-mannosidase 2
 UniProt Synonym Protein Names   
Golgi alpha-mannosidase II; AMan II; Man II; Mannosidase alpha class 2A member 1; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
 UniProt Gene Name    MAN2A1 [Similar Products]
 UniProt Synonym Gene Names    MANA2; AMan II; Man II [Similar Products]
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 NCBI Summary for MAN2A1    This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]
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 UniProt Comments for MAN2A1    MAN2A1: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. Belongs to the glycosyl hydrolase 38 family.

Protein type: EC 3.2.1.114; Glycan Metabolism - N-glycan biosynthesis; Hydrolase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q21.3

Cellular Component: Golgi membrane; membrane

Molecular Function: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity

Biological Process: mannose metabolic process; N-glycan processing; protein deglycosylation
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 Research Articles on MAN2A1    1. KCNQ and AP3S1, but not MAN2A1 or ALDH7A1 have a role in risk of type 2 diabetes in the Chinese Northern Han population
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAN2A1 antibodyPathways associated with anti-MAN2A1 antibody
 Reference Product  PubMed Publications
 MGAT1 antibody  >1 publications with MAN2A1 and MGAT1
 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Defective ALG1 Causes ALG1-CDG (CDG-1k) Pathway antibodies  Defective ALG1 Causes ALG1-CDG (CDG-1k) Pathway Diagram
 Defective ALG11 Causes ALG11-CDG (CDG-1p) Pathway antibodies  Defective ALG11 Causes ALG11-CDG (CDG-1p) Pathway Diagram
 Defective ALG12 Causes ALG12-CDG (CDG-1g) Pathway antibodies  Defective ALG12 Causes ALG12-CDG (CDG-1g) Pathway Diagram
 Defective ALG14 Causes Congenital Myasthenic Syndrome (ALG14-CMS) Pathway antibodies  Defective ALG14 Causes Congenital Myasthenic Syndrome (ALG14-CMS) Pathway Diagram
 Defective ALG2 Causes ALG2-CDG (CDG-1i) Pathway antibodies  Defective ALG2 Causes ALG2-CDG (CDG-1i) Pathway Diagram
 Defective ALG3 Causes ALG3-CDG (CDG-1d) Pathway antibodies  Defective ALG3 Causes ALG3-CDG (CDG-1d) Pathway Diagram
 Defective ALG6 Causes ALG6-CDG (CDG-1c) Pathway antibodies  Defective ALG6 Causes ALG6-CDG (CDG-1c) Pathway Diagram
 Defective ALG8 Causes ALG8-CDG (CDG-1h) Pathway antibodies  Defective ALG8 Causes ALG8-CDG (CDG-1h) Pathway Diagram
 Defective ALG9 Causes ALG9-CDG (CDG-1l) Pathway antibodies  Defective ALG9 Causes ALG9-CDG (CDG-1l) Pathway Diagram
Diseases associated with anti-MAN2A1 antibodyOrgans/Tissues associated with anti-MAN2A1 antibody
 Disease Name  Pubmed Publications
 Anemia Antibodies  >1 publications with MAN2A1 and Anemia
 Inflammation Antibodies  >1 publications with MAN2A1 and Inflammation
 Poisoning Antibodies  >1 publications with MAN2A1 and Poisoning
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with MAN2A1 and Blood
 Nerve Antibodies  >1 publications with MAN2A1 and Nerve
 Bladder Antibodies  >1 publications with MAN2A1 and Bladder
 Prostate Antibodies  >1 publications with MAN2A1 and Prostate
 Kidney Antibodies  >1 publications with MAN2A1 and Kidney
 Brain Antibodies  >1 publications with MAN2A1 and Brain
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