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anti-MKNK1 antibody :: Rabbit MAP kinase interacting serine/threonine kinase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS711617 anti-MKNK1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAP kinase interacting serine/threonine kinase 1 (MKNK1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human MAP kinase interacting serine/threonine kinase 1 polyclonal Antibody

 Product Synonym Names    MAP kinase interacting serine/threonine kinase 1; MKNK1; MNK1
 Product Gene Name   

anti-MKNK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606724
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human MKNK1
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6965 / sc-6961 / sc-6962 / sc-28780
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MKNK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MKNK1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for MKNK1. It may not necessarily be applicable to this product.
 NCBI GI #    21361101
 NCBI GeneID    8569
 NCBI Accession #    NP_003675.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003684.5 [Other Products]
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 UniProt Secondary Accession #    O00312; Q5TC06; Q5TC07; Q6V0N6; D3DQ20; D3DQ21 [Other Products]
 UniProt Related Accession #    Q9BUB5 [Other Products]
 Molecular Weight    39,104 Da [Similar Products]
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 NCBI Official Full Name    MAP kinase-interacting serine/threonine-protein kinase 1 isoform 1
 NCBI Official Synonym Full Names    MAP kinase interacting serine/threonine kinase 1
 NCBI Official Symbol    MKNK1 [Similar Products]
 NCBI Official Synonym Symbols   
MNK1
[Similar Products]
 NCBI Protein Information    MAP kinase-interacting serine/threonine-protein kinase 1; MAPK signal-integrating kinase 1; MAP kinase signal-integrating kinase 1
 UniProt Protein Name    MAP kinase-interacting serine/threonine-protein kinase 1
 UniProt Synonym Protein Names   
MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; Mnk1
 Protein Family    MAP kinase-interacting serine/threonine-protein kinase
 UniProt Gene Name    MKNK1 [Similar Products]
 UniProt Synonym Gene Names    MNK1; MAPK signal-integrating kinase 1; Mnk1 [Similar Products]
 UniProt Entry Name    MKNK1_HUMAN
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 NCBI Summary for MKNK1    This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for MKNK1    Mnk1: a CAM kinase of the MAPKKAPK family that can regulate translation. Following activation by MAP kinases, Mnk1 phosphorylates eIF4E at Ser209, increasing its affinity for the 7-methylguanosine-containing mRNA cap. Two MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for its kinase activity. Three alternatively spliced human isoforms have been described.

Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Translation; Protein kinase, CAMK; CAMK group; MAPKAPK family; MNK subfamily

Chromosomal Location of Human Ortholog: 1p33

Cellular Component: cytosol; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding

Biological Process: peptidyl-serine phosphorylation; fibroblast growth factor receptor signaling pathway; protein amino acid phosphorylation; response to salt stress; regulation of translational initiation
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 Research Articles on MKNK1    1. High expression of p-Mnk1 and p-eIF4E might be novel valuable biomarkers to predict poor prognosis of nasopharyngeal carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MKNK1 antibodyPathways associated with anti-MKNK1 antibody
 Reference Product  PubMed Publications
 EIF4E antibody  >81 publications with MKNK1 and EIF4E
 MAPK3 antibody  >12 publications with MKNK1 and MAPK3
 EIF4G1 antibody  >4 publications with MKNK1 and EIF4G1
 SPRY2 antibody  >2 publications with MKNK1 and SPRY2
 PLA2G4A antibody  >1 publications with MKNK1 and PLA2G4A
 MAPK14 antibody  >1 publications with MKNK1 and MAPK14
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Negative Regulation Of FGFR Signaling Pathway antibodies  Negative Regulation Of FGFR Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By FGFR Pathway antibodies  Signaling By FGFR Pathway Diagram
 Signaling By FGFR In Disease Pathway antibodies  Signaling By FGFR In Disease Pathway Diagram
Diseases associated with anti-MKNK1 antibodyOrgans/Tissues associated with anti-MKNK1 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >9 publications with MKNK1 and Necrosis
 Breast Neoplasms Antibodies  >5 publications with MKNK1 and Breast Neoplasms
 Nervous System Diseases Antibodies  >4 publications with MKNK1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >4 publications with MKNK1 and Cardiovascular Diseases
 Inflammation Antibodies  >4 publications with MKNK1 and Inflammation
 Hypertrophy Antibodies  >3 publications with MKNK1 and Hypertrophy
 Neoplasms, Experimental Antibodies  >3 publications with MKNK1 and Neoplasms, Experimental
 Lung Diseases Antibodies  >3 publications with MKNK1 and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >3 publications with MKNK1 and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >2 publications with MKNK1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with MKNK1 and Blood
 Kidney Antibodies  >8 publications with MKNK1 and Kidney
 Muscle Antibodies  >8 publications with MKNK1 and Muscle
 Vascular Antibodies  >6 publications with MKNK1 and Vascular
 Bone Antibodies  >5 publications with MKNK1 and Bone
 Brain Antibodies  >5 publications with MKNK1 and Brain
 Bone Marrow Antibodies  >4 publications with MKNK1 and Bone Marrow
 Lung Antibodies  >4 publications with MKNK1 and Lung
 Liver Antibodies  >3 publications with MKNK1 and Liver
 Skin Antibodies  >3 publications with MKNK1 and Skin
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