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anti-MAP1LC3A antibody :: Rabbit anti-Human, Rat MAP1LC3A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS611747 anti-MAP1LC3A antibody
Unit / Price
0.1 mL  /  $610 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAP1LC3A, Polyclonal Antibody

 Also Known As   

MAP1LC3A, NT (Microtubule Associated Protein 1 Light Chain 3 alpha, MAP1 Light Chain 3A, APG8, Autophagy Related Protein LC3A, Autophagy Related Ubiquitin-like Modifier LC3A, LC3A, MAP1 Light Chain 3 Like Protein 1, Microtubule Associated Proteins 1A/1B L

 Product Synonym Names    Anti -MAP1LC3A, NT (Microtubule Associated Protein 1 Light Chain 3 alpha, MAP1 Light Chain 3A, APG8, Autophagy Related Protein LC3A, Autophagy Related Ubiquitin-like Modifier LC3A, LC3A, MAP1 Light Chain 3 Like Protein 1, Microtubule Associated Proteins 1A/1B L
 Product Gene Name   

anti-MAP1LC3A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 20; NC_000020.10 (33134692..33148149). Location: 20cen-q13
 OMIM    601242
 3D Structure    ModBase 3D Structure for Q9H492
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Specificity    Recognizes human MAP1LC3A. Species Crossreactivity
 Purity/Purification    Serum
Serum
 Form/Format    Supplied as a liquid, 40% glycerol.
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 Immunogen    Synthetic peptide corresponding to the N-terminal of human MAP1LC3A protein conjugated to Blue Carrier Protein. The sequence is homologous with mouse and rat form of MAP1LC3A.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-MAP1LC3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MAP1LC3A antibody

   MAP1A and MAP1B are microtubule-associated protein which mediate the physical interactions between microtubules and components of the cytoskeleton (probably involved in autophagosome formation). MAP1A and MAP1B each consist of a heavy chain subunit and 3 different light chain subunits (LC1, LC2 and LC3). MAP1LC3A is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor form of MAP1LC3A is cleaved by APG4/ATG4B to form the cytosolic form LC3-1. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. MAP1LC3A is most abundant in heart, brain, liver, skeletal muscle and testis but is absent in thymus and peripheral leukocytes.
 Product Categories/Family for anti-MAP1LC3A antibody    Antibodies; Abs to Microtubule-associated Proteins
 Applications Tested/Suitable for anti-MAP1LC3A antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-MAP1LC3A antibody    Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1:100-1:1000
Immunohistochemistry: 1:100-1:1000
Immunofluorescence: 1:100-1:1000
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NCBI/Uniprot data below describe general gene information for MAP1LC3A. It may not necessarily be applicable to this product.
 NCBI GI #    14210522
 NCBI GeneID    84557
 NCBI Accession #    NP_115903.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_032514.2 [Other Products]
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 UniProt Primary Accession #    Q9H492 [Other Products]
 UniProt Secondary Accession #    Q9BXW5; E1P5P4; E1P5P5 [Other Products]
 UniProt Related Accession #    Q9H492 [Other Products]
 Molecular Weight    14,272 Da [Similar Products]
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 NCBI Official Full Name    microtubule-associated proteins 1A/1B light chain 3A isoform a
 NCBI Official Synonym Full Names    microtubule-associated protein 1 light chain 3 alpha
 NCBI Official Symbol    MAP1LC3A [Similar Products]
 NCBI Official Synonym Symbols   
LC3; LC3A; ATG8E; MAP1ALC3; MAP1BLC3
[Similar Products]
 NCBI Protein Information    microtubule-associated proteins 1A/1B light chain 3A; MAP1A/MAP1B LC3 A; OTTHUMP00000030696; OTTHUMP00000030697; OTTHUMP00000030698; MAP1A/1B light chain 3 A; MAP1A/MAP1B light chain 3 A; autophagy-related protein LC3 A; MAP1 light chain 3-like protein 1; autophagy-related ubiquitin-like modifier LC3 A
 UniProt Protein Name    Microtubule-associated proteins 1A/1B light chain 3A
 UniProt Synonym Protein Names   
Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B light chain 3 A; MAP1A/MAP1B LC3 A; Microtubule-associated protein 1 light chain 3 alpha
 Protein Family    Microtubule-associated protein
 UniProt Gene Name    MAP1LC3A [Similar Products]
 UniProt Entry Name    MLP3A_HUMAN
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 NCBI Summary for MAP1LC3A    MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for MAP1LC3A    LC3A: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy; Vesicle; Ubiquitin-like modifier; Microtubule-binding

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: microtubule; extrinsic to membrane; late endosome; autophagic vacuole; cytoplasmic vesicle; cytosol

Molecular Function: protein binding; phosphatidylethanolamine binding; microtubule binding; GABA receptor binding; phospholipid binding

Biological Process: mitochondrion degradation; cellular response to nitrogen starvation; autophagic vacuole formation
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 Research Articles on MAP1LC3A    1. The fusion activity of LC3 is mediated by positively charged amino acids, whereas the activity of GATE-16 is mediated by hydrophobic interactions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAP1LC3A antibodyPathways associated with anti-MAP1LC3A antibody
 Reference Product  PubMed Publications
 MAP1A antibody  >1 publications with MAP1LC3A and MAP1A
 Products by Pathway  Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
Diseases associated with anti-MAP1LC3A antibodyOrgans/Tissues associated with anti-MAP1LC3A antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with MAP1LC3A and Neoplasms
 Death Antibodies  >4 publications with MAP1LC3A and Death
 Breast Neoplasms Antibodies  >3 publications with MAP1LC3A and Breast Neoplasms
 Nervous System Diseases Antibodies  >2 publications with MAP1LC3A and Nervous System Diseases
 Carcinoma Antibodies  >2 publications with MAP1LC3A and Carcinoma
 Neoplasm Invasiveness Antibodies  >1 publications with MAP1LC3A and Neoplasm Invasiveness
 Carcinoma, Small Cell Antibodies  >1 publications with MAP1LC3A and Carcinoma, Small Cell
 Adenocarcinoma Antibodies  >1 publications with MAP1LC3A and Adenocarcinoma
 Carcinoma, Ductal, Breast Antibodies  >1 publications with MAP1LC3A and Carcinoma, Ductal, Breast
 Genital Neoplasms, Female Antibodies  >1 publications with MAP1LC3A and Genital Neoplasms, Female
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with MAP1LC3A and Brain
 Kidney Antibodies  >2 publications with MAP1LC3A and Kidney
 Lung Antibodies  >2 publications with MAP1LC3A and Lung
 Prostate Antibodies  >1 publications with MAP1LC3A and Prostate
 Uterus Antibodies  >1 publications with MAP1LC3A and Uterus
 Liver Antibodies  >1 publications with MAP1LC3A and Liver
 Muscle Antibodies  >1 publications with MAP1LC3A and Muscle
 Embryonic Tissue Antibodies  >1 publications with MAP1LC3A and Embryonic Tissue
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