NP_001036065.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
Calculated MW: 91kDa
NCBI Official Full Name
mitogen-activated protein kinase kinase kinase kinase 1 isoform 1
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase kinase kinase 1
NCBI Official Synonym Symbols
NCBI Protein Information
mitogen-activated protein kinase kinase kinase kinase 1
UniProt Protein Name
Mitogen-activated protein kinase kinase kinase kinase 1
UniProt Synonym Protein Names
Hematopoietic progenitor kinase; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1
UniProt Synonym Gene Names
UniProt Entry Name
M4K1_HUMAN
UniProt Comments for MAP4K1
HPK1: a protein kinase of the STE20 family. Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. May play a role in hematopoietic lineage decisions and growth regulation. Positively regulated by PGE2 and a negative regulator of PGE2-induced FOS gene transcription.
Protein type: EC 2.7.11.1; Protein kinase, STE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; KHS subfamily
Chromosomal Location of Human Ortholog: 19q13.1-q13.4
Cellular Component: cytoplasm; membrane
Molecular Function: ATP binding; MAP kinase kinase kinase kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: activation of JNK activity; activation of MAPKKK activity; cell proliferation; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of mitotic cell cycle; response to stress
Research Articles on MAP4K1
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Pathways associated with anti-MAP4K1 antibody
Diseases associated with anti-MAP4K1 antibody
Organs/Tissues associated with anti-MAP4K1 antibody
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