NP_006566.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
95,040 Da
NCBI Official Full Name
mitogen-activated protein kinase kinase kinase kinase 5
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase kinase kinase 5
NCBI Protein Information
mitogen-activated protein kinase kinase kinase kinase 5
UniProt Protein Name
Mitogen-activated protein kinase kinase kinase kinase 5
UniProt Synonym Protein Names
Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5
UniProt Synonym Gene Names
UniProt Entry Name
M4K5_HUMAN
NCBI Summary for MAP4K5
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for MAP4K5
KHS1: a serine/threonine protein kinase of the STE20 family. Highly similar to yeast SPS1/STE20 kinase. Activates Jun kinase in mammalian cells, which suggested a role in stress response.
Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; KHS subfamily
Chromosomal Location of Human Ortholog: 14q11.2-q21
Cellular Component: cytoplasm
Molecular Function: ATP binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: activation of JNK activity; protein amino acid phosphorylation
Research Articles on MAP4K5
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-MAP4K5 antibody
Diseases associated with anti-MAP4K5 antibody
Organs/Tissues associated with anti-MAP4K5 antibody
|