Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow MAPK3 rightarrow Polyclonal MAPK3  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Big Endothelin (Big ET) ELISA Kit
 • Serum amyloid A-1 protein (SAA1) Antibody
 • CBP Recombinant Protein
 • solute carrier family 26, member 4 (SLC26A4) ELISA Kit
 • Forkhead box protein A4-B (foxa4-b) Recombinant Protein
 • Influenza A Antibody
 • oxoglutarate dehydrogenase-like (OGDHL) Antibody
 • Gliadin Antibody
 • SAP18 Antibody
 • Hepatocyte growth factor (Hgf) Recombinant Protein
 • Connexin 40 (CX40) ELISA Kit
 • TRAF2 Antibody
 • Actin, alpha skeletal muscle (acta1) Recombinant Protein
 • 30S ribosomal protein S15 (rpsO) Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-MAPK3 antibody :: Rabbit MAPK3 / ERK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241505
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAPK3 / ERK1, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human MAPK3 / ERK1

 Product Synonym Names    Anti-MAPK3 / ERK1 Antibody (Internal) IHC-plus; MAPK3; ERK-1; ERT2; HUMKER1A; HS44KDAP; MAP kinase 1; MAP kinase isoform p44; MAPK 1; MAPK 3; p44; p44MAPK; p44-MAPK; p44ERK1; Insulin-stimulated MAP2 kinase; MAP kinase 3; p44-ERK1; ERK1; PRKM3; Human MAPK3; ERK1
 Product Gene Name   

anti-MAPK3 antibody

[Similar Products]
 Product Synonym Gene Name    ERK1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    601795
 3D Structure    ModBase 3D Structure for P27361
Section Bar
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gibbon, Gorilla, Human, Monkey
Predicted Reactivity: Mouse, Rat, Bovine, Dog, Hamster, Horse, Pig, Rabbit (at least 90% immunogen sequence identity)
Section Bar
 Specificity    Human MAPK3 / ERK1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except MAPK1 (70%).
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
Section Bar
 Target Species    Human
 Immunogen Description    Synthetic 20 amino acid peptide from internal region of human MAPK3 / ERK1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Mouse, Rat, Bovine, Hamster, Elephant, Panda, Horse, Pig (95%).
 Immunogen Type    Synthetic peptide
 Immunogen    MAPK3 / ERK1 antibody was raised against synthetic 20 amino acid peptide from internal region of human MAPK3 / ERK1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Mouse, Rat, Bovine, Hamster, Elephant, Panda, Horse, Pig (95%); Dog, Rabbit, Opossum, Platypus (90%); Bat (85%).
 Antigen Modification    Internal
Section Bar
 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-MAPK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-MAPK3 antibody

   ERK1, a MAPK -type protein kinase, is a member of the Ras-MAPK pathway. This pathway modulates the activity of transcription factors, structural proteins, and other protein kinases, leading to biological responses such as cell proliferation and differentiation. Inactive ERK1 associates with MAPK/ERK kinases (MEK) 1 and 2 in the cytosol. Upon stimulation, MEK1/2 phosphorylates and activates ERK1 causing dissociation of the MEK/ERK complex.
 Product Categories/Family for anti-MAPK3 antibody    Family: Protein Kinase
Subfamily: MAPK
 Applications Tested/Suitable for anti-MAPK3 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-MAPK3 antibody    IHC-P (4 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
Section Bar
 Immunohistochemistry (IHC) of anti-MAPK3 antibody    Anti-MAPK3 / ERK1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-MAPK3 antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-MAPK3 antibody    Anti-MAPK3 / ERK1 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-MAPK3 antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-MAPK3 antibody    Anti-MAPK3 / ERK1 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-MAPK3 antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-MAPK3 antibody    Anti-MAPK3 / ERK1 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-MAPK3 antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-MAPK3 antibody    Anti-MAPK3 / ERK1 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-MAPK3 antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for MAPK3. It may not necessarily be applicable to this product.
 NCBI GI #    91718897
 NCBI GeneID    5595
 NCBI Accession #    NP_001035145.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001040056.2 [Other Products]
Section Bar
 UniProt Primary Accession #    P27361 [Other Products]
 UniProt Secondary Accession #    Q8NHX1; A8CZ58; B0LPG3 [Other Products]
 UniProt Related Accession #    P27361 [Other Products]
 Molecular Weight    40,088 Da
Table BarTOPTable Bar
 NCBI Official Full Name    mitogen-activated protein kinase 3 isoform 2
 NCBI Official Synonym Full Names    mitogen-activated protein kinase 3
 NCBI Official Symbol    MAPK3 [Similar Products]
 NCBI Official Synonym Symbols   
ERK1; ERT2; ERK-1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK
[Similar Products]
 NCBI Protein Information    mitogen-activated protein kinase 3; MAPK 1; MAP kinase isoform p44; insulin-stimulated MAP2 kinase; extracellular signal-related kinase 1; extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase
 UniProt Protein Name    Mitogen-activated protein kinase 3
 UniProt Synonym Protein Names   
ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1
 UniProt Gene Name    MAPK3 [Similar Products]
 UniProt Synonym Gene Names    ERK1; PRKM3; MAP kinase 3; MAPK 3; ERK-1; p44-MAPK [Similar Products]
 UniProt Entry Name    MK03_HUMAN
Section Bar
 NCBI Summary for MAPK3    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for MAPK3    ERK1: a serine/threonine kinase of the GMGC group that plays a critical role in the regulation of cell growth and differentiation. ERK1 (MAPK3) and ERK2 (MAPK1) play central roles in MAPK cascades and are activated by a wide variety of extracellular signals including growth and neurotrophic factors, cytokines, hormones and neurotransmitters. Depending on the cellular context, MAPK cascades mediate diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. MAPK cascades also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. Activation of MAP kinases occurs through phosphorylation of threonine and tyrosine residues at the sequence T*EY* by upstream MAP kinase kinases, MEK1 and -2. Phosphorylation of both the threonine and tyrosine are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates.

Protein type: EC 2.7.11.24; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; Kinase, protein; CMGC group; MAPK family; MAPK/ERK subfamily; ERK subfamily

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: Golgi apparatus; focal adhesion; mitochondrion; early endosome; nuclear envelope; pseudopodium; caveola; cytosol; microtubule cytoskeleton; nucleoplasm; cytoskeleton; late endosome; nucleus

Molecular Function: MAP kinase activity; protein binding; phosphotyrosine binding; ATP binding; phosphatase binding

Biological Process: axon guidance; activation of MAPKK activity; DNA damage induced protein phosphorylation; nerve growth factor receptor signaling pathway; viral reproduction; positive regulation of histone phosphorylation; activation of MAPK activity; apoptosis; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; sensory perception of pain; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; BMP signaling pathway; toll-like receptor 5 signaling pathway; response to exogenous dsRNA; regulation of transcription factor activity; small GTPase mediated signal transduction; lipopolysaccharide-mediated signaling pathway; toll-like receptor 4 signaling pathway; epidermal growth factor receptor signaling pathway; platelet activation; fibroblast growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; transcription from RNA polymerase I promoter; cell cycle; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of stress-activated MAPK cascade; organ morphogenesis; cartilage development; Ras protein signal transduction; toll-like receptor signaling pathway; insulin receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of histone acetylation; gene expression; toll-like receptor 9 signaling pathway; positive regulation of protein amino acid phosphorylation; transcription initiation from RNA polymerase I promoter; vascular endothelial growth factor receptor signaling pathway; blood coagulation; phosphorylation; regulation of cytoskeleton organization and biogenesis
Table BarTOPTable Bar
 Research Articles on MAPK3    1. ERK, AKT, and GSK-3beta have roles in boldine-induced cell cycle arrest and apoptosis in T24 human bladder cancer cell line
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products related to Rabbit Polyclonal to Human MAPK3 / ERK1
 Catalog #  Product Name  Catalog #  Product Name
 MBS241505  Rabbit Polyclonal to Human MAPK3 / ERK1  MBS245571  Mouse Monoclonal [clone 3C9] (IgG2a,k) to Human MAPK3 / ERK1
 MBS247395  Rabbit Polyclonal (IgG) to Human MAPK3 / ERK1  MBS240070  Rabbit Polyclonal to Human MAPK3 / ERK1
 MBS240041  Rabbit Polyclonal to Human MAPK3 / ERK1
Products associated with anti-MAPK3 antibodyPathways associated with anti-MAPK3 antibody
 Reference Product  PubMed Publications
 MAP2K1 antibody  >364 publications with MAPK3 and MAP2K1
 MAP2K2 antibody  >152 publications with MAPK3 and MAP2K2
 ELK1 antibody  >109 publications with MAPK3 and ELK1
 DUSP1 antibody  >98 publications with MAPK3 and DUSP1
 CREB1 antibody  >34 publications with MAPK3 and CREB1
 DUSP6 antibody  >33 publications with MAPK3 and DUSP6
 DUSP4 antibody  >12 publications with MAPK3 and DUSP4
 PTPN7 antibody  >5 publications with MAPK3 and PTPN7
 PTPRR antibody  >2 publications with MAPK3 and PTPRR
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of The AP-1 Family Of Transcription Factors Pathway antibodies  Activation Of The AP-1 Family Of Transcription Factors Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
Diseases associated with anti-MAPK3 antibodyOrgans/Tissues associated with anti-MAPK3 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >771 publications with MAPK3 and Necrosis
 Inflammation Antibodies  >737 publications with MAPK3 and Inflammation
 Cardiovascular Diseases Antibodies  >735 publications with MAPK3 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >545 publications with MAPK3 and Nervous System Diseases
 Breast Neoplasms Antibodies  >382 publications with MAPK3 and Breast Neoplasms
 Heart Diseases Antibodies  >306 publications with MAPK3 and Heart Diseases
 Hypertension Antibodies  >253 publications with MAPK3 and Hypertension
 Hypertrophy Antibodies  >244 publications with MAPK3 and Hypertrophy
 Liver Diseases Antibodies  >231 publications with MAPK3 and Liver Diseases
 Fibrosis Antibodies  >227 publications with MAPK3 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1681 publications with MAPK3 and Vascular
 Blood Antibodies  >1614 publications with MAPK3 and Blood
 Muscle Antibodies  >1516 publications with MAPK3 and Muscle
 Brain Antibodies  >1206 publications with MAPK3 and Brain
 Heart Antibodies  >686 publications with MAPK3 and Heart
 Lung Antibodies  >612 publications with MAPK3 and Lung
 Bone Antibodies  >521 publications with MAPK3 and Bone
 Liver Antibodies  >512 publications with MAPK3 and Liver
 Kidney Antibodies  >503 publications with MAPK3 and Kidney
 Nerve Antibodies  >484 publications with MAPK3 and Nerve
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions