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anti-MAPK3 antibody :: Rabbit MAPK3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2517018
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAPK3, Polyclonal Antibody

★Popular Item★
 Also Known As   

MAPK3 Polyclonal Antibody

 Product Synonym Names    ERK1, ERT2, ERK-1, PRKM3, P44ERK1, P44MAPK, HS44KDAP, HUMKER1A, p44-ERK1, p44-MAPK
 Product Gene Name   

anti-MAPK3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601795
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    0.5mg/mL (lot specific)
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 Immunogen    Synthetic peptide of human MAPK3
 Calculated Molecular Weight: 40kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MAPK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MAPK3 antibody

   The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
 Product Categories/Family for anti-MAPK3 antibody    Stem cells; Cell biology; Epigenetics
 Applications Tested/Suitable for anti-MAPK3 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-MAPK3 antibody    WB: 1:200-1:1000
IHC: 1:15-1:50
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 Western Blot (WB) of anti-MAPK3 antibody    Western Blot analysis of Human liver cancer tissue and 231 cell using MAPK3 Polyclonal Antibody at dilution of 1:250
anti-MAPK3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MAPK3 antibody    Immunohistochemistry of paraffin-embedded Human lung cancer using MAPK3 Polyclonal Antibody at dilution of 1:15
anti-MAPK3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MAPK3. It may not necessarily be applicable to this product.
 NCBI GI #    12652899
 NCBI GeneID    5595
 NCBI Accession #    AAH00205.1 [Other Products]
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 UniProt Secondary Accession #    Q8NHX1; A8CZ58; B0LPG3 [Other Products]
 UniProt Related Accession #    P27361 [Other Products]
 Molecular Weight    40,088 Da
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 NCBI Official Full Name    MAPK3 protein, partial
 NCBI Official Synonym Full Names    mitogen-activated protein kinase 3
 NCBI Official Symbol    MAPK3 [Similar Products]
 NCBI Official Synonym Symbols   
ERK1; ERT2; ERK-1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK
[Similar Products]
 NCBI Protein Information    mitogen-activated protein kinase 3; MAP kinase isoform p44; MAPK 1; extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; insulin-stimulated MAP2 kinase; microtubule-associated protein 2 kinase
 UniProt Protein Name    Mitogen-activated protein kinase 3
 UniProt Synonym Protein Names   
ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1
 UniProt Gene Name    MAPK3 [Similar Products]
 UniProt Synonym Gene Names    ERK1; PRKM3; MAP kinase 3; MAPK 3; ERK-1; p44-MAPK [Similar Products]
 UniProt Entry Name    MK03_HUMAN
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 NCBI Summary for MAPK3    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MAPK3    ERK1: a serine/threonine kinase of the GMGC group that plays a critical role in the regulation of cell growth and differentiation. ERK1 (MAPK3) and ERK2 (MAPK1) play central roles in MAPK cascades and are activated by a wide variety of extracellular signals including growth and neurotrophic factors, cytokines, hormones and neurotransmitters. Depending on the cellular context, MAPK cascades mediate diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. MAPK cascades also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. Activation of MAP kinases occurs through phosphorylation of threonine and tyrosine residues at the sequence T*EY* by upstream MAP kinase kinases, MEK1 and -2. Phosphorylation of both the threonine and tyrosine are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.24; Protein kinase, CMGC; CMGC group; MAPK family; MAPK/ERK subfamily; ERK subfamily

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: Golgi apparatus; focal adhesion; mitochondrion; early endosome; nuclear envelope; pseudopodium; caveola; cytosol; microtubule cytoskeleton; nucleoplasm; cytoskeleton; late endosome; nucleus

Molecular Function: MAP kinase activity; protein binding; phosphotyrosine binding; ATP binding; phosphatase binding

Biological Process: axon guidance; nerve growth factor receptor signaling pathway; activation of MAPKK activity; DNA damage induced protein phosphorylation; positive regulation of histone phosphorylation; viral reproduction; activation of MAPK activity; apoptosis; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; sensory perception of pain; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; BMP signaling pathway; toll-like receptor 5 signaling pathway; response to exogenous dsRNA; regulation of transcription factor activity; small GTPase mediated signal transduction; lipopolysaccharide-mediated signaling pathway; toll-like receptor 4 signaling pathway; epidermal growth factor receptor signaling pathway; platelet activation; fibroblast growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; transcription from RNA polymerase I promoter; cell cycle; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of stress-activated MAPK cascade; organ morphogenesis; cartilage development; Ras protein signal transduction; insulin receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of histone acetylation; gene expression; positive regulation of protein amino acid phosphorylation; toll-like receptor 9 signaling pathway; blood coagulation; vascular endothelial growth factor receptor signaling pathway; transcription initiation from RNA polymerase I promoter; phosphorylation; regulation of cytoskeleton organization and biogenesis
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 Research Articles on MAPK3    1. ERK1/2 as well as STAT3 (Ser727) phosphorylation play an important role in LIF-mediated JEG-3 trophoblastic cell invasion and gene expression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAPK3 antibodyPathways associated with anti-MAPK3 antibody
 Reference Product  PubMed Publications
 MAP2K1 antibody  >364 publications with MAPK3 and MAP2K1
 MAP2K2 antibody  >153 publications with MAPK3 and MAP2K2
 ELK1 antibody  >110 publications with MAPK3 and ELK1
 DUSP1 antibody  >98 publications with MAPK3 and DUSP1
 CREB1 antibody  >34 publications with MAPK3 and CREB1
 DUSP6 antibody  >33 publications with MAPK3 and DUSP6
 DUSP4 antibody  >12 publications with MAPK3 and DUSP4
 PTPN7 antibody  >5 publications with MAPK3 and PTPN7
 PTPRR antibody  >2 publications with MAPK3 and PTPRR
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of The AP-1 Family Of Transcription Factors Pathway antibodies  Activation Of The AP-1 Family Of Transcription Factors Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
Diseases associated with anti-MAPK3 antibodyOrgans/Tissues associated with anti-MAPK3 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >774 publications with MAPK3 and Necrosis
 Cardiovascular Diseases Antibodies  >741 publications with MAPK3 and Cardiovascular Diseases
 Inflammation Antibodies  >741 publications with MAPK3 and Inflammation
 Nervous System Diseases Antibodies  >547 publications with MAPK3 and Nervous System Diseases
 Breast Neoplasms Antibodies  >384 publications with MAPK3 and Breast Neoplasms
 Heart Diseases Antibodies  >310 publications with MAPK3 and Heart Diseases
 Hypertension Antibodies  >254 publications with MAPK3 and Hypertension
 Hypertrophy Antibodies  >247 publications with MAPK3 and Hypertrophy
 Liver Diseases Antibodies  >232 publications with MAPK3 and Liver Diseases
 Fibrosis Antibodies  >230 publications with MAPK3 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1689 publications with MAPK3 and Vascular
 Blood Antibodies  >1619 publications with MAPK3 and Blood
 Muscle Antibodies  >1525 publications with MAPK3 and Muscle
 Brain Antibodies  >1214 publications with MAPK3 and Brain
 Heart Antibodies  >693 publications with MAPK3 and Heart
 Lung Antibodies  >615 publications with MAPK3 and Lung
 Bone Antibodies  >524 publications with MAPK3 and Bone
 Liver Antibodies  >514 publications with MAPK3 and Liver
 Kidney Antibodies  >505 publications with MAPK3 and Kidney
 Nerve Antibodies  >488 publications with MAPK3 and Nerve
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