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anti-MAPK9 antibody :: Rabbit anti-Human MAPK9 / JNK2 / SAPK Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241719
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAPK9 / JNK2 / SAPK, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human MAPK9 / JNK2 / SAPK

 Product Synonym Names    Anti-MAPK9 / JNK2 / SAPK Antibody (C-Terminus) IHC-plus; MAPK9; C-Jun kinase 2; C-Jun N-terminal kinase 2; JNK2B; JNK2; JNK2ALPHA; MAP kinase 9; p54a; JNK2BETA; PRKM9; SAPK; MAPK 9; p54aSAPK; SAPK1a; JNK-55; JNK2A; Jun kinase; Human MAPK9; JNK2; SAPK
 Product Gene Name   

anti-MAPK9 antibody

[Similar Products]
 Product Synonym Gene Name    JNK2; SAPK [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602896
 3D Structure    ModBase 3D Structure for P45984
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    synthetic peptide corresponding to C-terminal residues of human MAPK9 (Mitogen-activated protein kinase 9)
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.01% sodium azide, 50% glycerol.
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human MAPK9 / JNK2.
 Immunogen Type    Synthetic peptide
 Immunogen    MAPK9 / JNK2 / SAPK antibody was raised against synthetic peptide from human MAPK9 / JNK2.
 Antigen Modification    C-Terminus
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-MAPK9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MAPK9 antibody

   JNK2, a MAPK type protein kinase, regulates cell apoptosis, differentiation and growth in response to growth factors, inflammatory cytokines and cellular stress. JNK2 is phosphorylated by by MKK4/MAP2K4 and MKK7/MAP2K7. Activated JNK2 translocates to the nucleus where it phosphorylates transcription factors, including c-Jun, ATF2, ELK1, Jun-D and NFAT4.
 Product Categories/Family for anti-MAPK9 antibody    Family: Protein Kinase
Subfamily: MAPK
 Applications Tested/Suitable for anti-MAPK9 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-MAPK9 antibody    ELISA (1 ug/ml), IHC-P (20 ug/ml), WB (1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-MAPK9 antibody    Anti-MAPK9 / JNK2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
anti-MAPK9 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MAPK9. It may not necessarily be applicable to this product.
 NCBI GI #    21237736
 NCBI GeneID    5601
 NCBI Accession #    NP_002743.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_002752.4 [Other Products]
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 UniProt Primary Accession #    P45984 [Other Products]
 UniProt Secondary Accession #    Q15708; Q15710; Q15711; Q8N5C5; A8K0S3; B5BU66; B5M0B4; D3DWQ8; D3DWQ9 [Other Products]
 UniProt Related Accession #    P45984 [Other Products]
 Molecular Weight    27,334 Da
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 NCBI Official Full Name    mitogen-activated protein kinase 9 isoform alpha2
 NCBI Official Synonym Full Names    mitogen-activated protein kinase 9
 NCBI Official Symbol    MAPK9 [Similar Products]
 NCBI Official Synonym Symbols   
JNK2; SAPK; p54a; JNK2A; JNK2B; PRKM9; JNK-55; SAPK1a; JNK2BETA; p54aSAPK; JNK2ALPHA
[Similar Products]
 NCBI Protein Information    mitogen-activated protein kinase 9; MAPK 9; Jun kinase; MAP kinase 9; c-Jun kinase 2; c-Jun N-terminal kinase 2; stress-activated protein kinase 1a; stress-activated protein kinase JNK2
 UniProt Protein Name    Mitogen-activated protein kinase 9
 UniProt Synonym Protein Names   
JNK-55; Stress-activated protein kinase 1a; SAPK1a; Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2
 UniProt Gene Name    MAPK9 [Similar Products]
 UniProt Synonym Gene Names    JNK2; PRKM9; SAPK1A; MAP kinase 9; MAPK 9; SAPK1a [Similar Products]
 UniProt Entry Name    MK09_HUMAN
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 NCBI Summary for MAPK9    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]
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 UniProt Comments for MAPK9    JNK2: a protein kinase of the MAPK family that is potently activated by a variety of environmental stresses including UV radiation. Phosphorylates specific transcription factors such as c-Jun and ATF2, mediating immediate-early gene expression. Closely related to JNK1. Both are involved in UV radiation induced apoptosis. Blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells in the mouse. Four alternatively-spliced isoforms have been described.

Protein type: EC 2.7.11.24; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; Kinase, protein; CMGC group; MAPK family; JNK subfamily; MAPK/JNK subfamily

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: nucleoplasm; mitochondrion; cytosol

Molecular Function: protein binding; caspase activator activity; mitogen-activated protein kinase kinase kinase binding; JUN kinase activity; transcription factor binding; ATP binding

Biological Process: positive regulation of nitric oxide biosynthetic process; central nervous system development; regulation of protein ubiquitination; response to toxin; positive regulation of transcription, DNA-dependent; rhythmic process; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; regulation of JNK cascade; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; regulation of transcription factor activity; response to stress; JNK cascade; protein targeting to mitochondrion; toll-like receptor 4 signaling pathway; neurite development; positive regulation of prostaglandin biosynthetic process; response to drug; caspase activation; release of cytochrome c from mitochondria; MyD88-independent toll-like receptor signaling pathway; regulation of circadian rhythm; positive regulation of chemokine production; JUN phosphorylation; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; response to cadmium ion; response to mechanical stimulus; positive regulation of prostaglandin secretion; toll-like receptor signaling pathway; innate immune response; positive regulation of protein amino acid phosphorylation; toll-like receptor 9 signaling pathway; positive regulation of nitric-oxide synthase biosynthetic process; response to amine stimulus
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 Research Articles on MAPK9    1. MiR-4782-3p inhibited cell proliferation in NSCLC by targeting USP14, ZEB2 and XIAP.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAPK9 antibodyPathways associated with anti-MAPK9 antibody
 Reference Product  PubMed Publications
 JUN antibody  >12 publications with MAPK9 and JUN
 FOS antibody  >1 publications with MAPK9 and FOS
 RAC1 antibody  >1 publications with MAPK9 and RAC1
 TP53 antibody  >1 publications with MAPK9 and TP53
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of The AP-1 Family Of Transcription Factors Pathway antibodies  Activation Of The AP-1 Family Of Transcription Factors Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
Diseases associated with anti-MAPK9 antibodyOrgans/Tissues associated with anti-MAPK9 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >4 publications with MAPK9 and Breast Neoplasms
 Inflammation Antibodies  >4 publications with MAPK9 and Inflammation
 Disease Models, Animal Antibodies  >3 publications with MAPK9 and Disease Models, Animal
 Lung Neoplasms Antibodies  >3 publications with MAPK9 and Lung Neoplasms
 Acute Kidney Injury Antibodies  >2 publications with MAPK9 and Acute Kidney Injury
 Lung Diseases Antibodies  >1 publications with MAPK9 and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with MAPK9 and Carcinoma, Hepatocellular
 Edema Antibodies  >1 publications with MAPK9 and Edema
 Necrosis Antibodies  >1 publications with MAPK9 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with MAPK9 and Blood
 Vascular Antibodies  >4 publications with MAPK9 and Vascular
 Lung Antibodies  >4 publications with MAPK9 and Lung
 Muscle Antibodies  >3 publications with MAPK9 and Muscle
 Kidney Antibodies  >3 publications with MAPK9 and Kidney
 Brain Antibodies  >2 publications with MAPK9 and Brain
 Liver Antibodies  >1 publications with MAPK9 and Liver
 Prostate Antibodies  >1 publications with MAPK9 and Prostate
 Mammary Gland Antibodies  >1 publications with MAPK9 and Mammary Gland
 Pancreas Antibodies  >1 publications with MAPK9 and Pancreas
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