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anti-MAPKAPK-2 antibody :: Rabbit MAPKAPK-2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS857571
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAPKAPK-2, Polyclonal Antibody

★Popular Item★
 Also Known As   

MAPKAPK-2 (Phospho-Thr334) Antibody

 Product Gene Name   

anti-MAPKAPK-2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602006
 3D Structure    ModBase 3D Structure for P49137
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    MAPKAPK-2 (Phospho-Thr334) antibody detects endogenous levels of MAPKAPK-2 only when phosphorylated at threonine 334.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    50ug/50ul (lot specific)
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human MAPKAPK-2 around the phosphorylation site of threonine 334 (P-Q-TP-P-L).
 Pathway    MAPK, Kinase/Phosphatases
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-MAPKAPK-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-MAPKAPK-2 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-MAPKAPK-2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-MAPKAPK-2 antibody    WB: 1:500~1:1000, IHC: 1:50-1:100
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 Testing Data of anti-MAPKAPK-2 antibody    P-Peptide - +
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using MAPKAPK-2 (Phospho-Thr334) antibody (E011308).
anti-MAPKAPK-2 antibody Testing Data image
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 Testing Data #2 of anti-MAPKAPK-2 antibody    Western blot analysis of extract from HeLa cells treated with UV (20min), using MAPKAPK-2 (Ab-334) antibody and MAPKAPK-2 (Phospho- Thr334) antibody (E011308, Lane 3 and 4).
anti-MAPKAPK-2 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for MAPKAPK-2. It may not necessarily be applicable to this product.
 NCBI GI #    10863901
 NCBI GeneID    9261
 NCBI Accession #    NP_004750.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004759.4 [Other Products]
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 UniProt Primary Accession #    P49137 [Other Products]
 UniProt Secondary Accession #    Q5SY30; Q5SY41; Q8IYD6 [Other Products]
 UniProt Related Accession #    P49137 [Other Products]
 Molecular Weight    42,203 Da
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 NCBI Official Full Name    MAP kinase-activated protein kinase 2 isoform 1
 NCBI Official Synonym Full Names    mitogen-activated protein kinase-activated protein kinase 2
 NCBI Official Symbol    MAPKAPK2 [Similar Products]
 NCBI Official Synonym Symbols   
MK2; MK-2; MAPKAP-K2
[Similar Products]
 NCBI Protein Information    MAP kinase-activated protein kinase 2; MAPKAP kinase 2; MAPK-activated protein kinase 2
 UniProt Protein Name    MAP kinase-activated protein kinase 2
 UniProt Gene Name    MAPKAPK2 [Similar Products]
 UniProt Synonym Gene Names    MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2 [Similar Products]
 UniProt Entry Name    MAPK2_HUMAN
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 NCBI Summary for MAPKAPK-2    This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MAPKAPK-2    MAPKAPK2: a member of the MAPKAPK family of protein kinases. It is phosphorylated and activated by p38 in response to cytokines, stress and chemotactic factors.MAPKAPK-2 is apparently a direct target of p38 MAPK. HSP27 is one of its in vivo substrates. Two transcript variants encoding two different isoforms have been described.

Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; CAMK group; MAPKAPK family; MAPKAPK subfamily

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: nucleoplasm; centrosome; cytoplasm; cytosol; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; signal transducer activity; ATP binding; protein kinase activity

Biological Process: nerve growth factor receptor signaling pathway; activation of MAPK activity; stress-activated MAPK cascade; leukotriene metabolic process; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; regulation of interleukin-6 production; response to stress; arachidonic acid metabolic process; inflammatory response; inner ear development; toll-like receptor 4 signaling pathway; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; peptidyl-serine phosphorylation; response to cytokine stimulus; Ras protein signal transduction; toll-like receptor signaling pathway; innate immune response; regulation of tumor necrosis factor production; gene expression; toll-like receptor 9 signaling pathway; G2/M transition DNA damage checkpoint; vascular endothelial growth factor receptor signaling pathway; response to DNA damage stimulus
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Product References and Citations for anti-MAPKAPK-2 antibody

   Rouse, J. et al. (1994) Cell 78, 1027-1037.
Ben-Levy, R. et al. (1995) EMBO J. 14, 5920-5930.
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 Research Articles on MAPKAPK-2    1. MK2 mediates gemcitabine efficacy in pancreatic cancer cells that respond to the drug, suggesting that the p38/MK2 pathway represents a determinant of the efficacy by that gemcitabine counteracts pancreatic cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAPKAPK-2 antibodyPathways associated with anti-MAPKAPK-2 antibody
 Reference Product  PubMed Publications
 HSPB1 antibody  >52 publications with MAPKAPK-2 and HSPB1
 MAPK14 antibody  >23 publications with MAPKAPK-2 and MAPK14
 ZFP36 antibody  >8 publications with MAPKAPK-2 and ZFP36
 ALOX5 antibody  >8 publications with MAPKAPK-2 and ALOX5
 SRF antibody  >4 publications with MAPKAPK-2 and SRF
 ETV1 antibody  >2 publications with MAPKAPK-2 and ETV1
 TSC2 antibody  >1 publications with MAPKAPK-2 and TSC2
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Butyrate Response Factor 1 (BRF1) Destabilizes MRNA Pathway antibodies  Butyrate Response Factor 1 (BRF1) Destabilizes MRNA Pathway Diagram
 CREB Phosphorylation Pathway antibodies  CREB Phosphorylation Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
Diseases associated with anti-MAPKAPK-2 antibodyOrgans/Tissues associated with anti-MAPKAPK-2 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >135 publications with MAPKAPK-2 and Necrosis
 Inflammation Antibodies  >96 publications with MAPKAPK-2 and Inflammation
 Nervous System Diseases Antibodies  >26 publications with MAPKAPK-2 and Nervous System Diseases
 Heart Diseases Antibodies  >19 publications with MAPKAPK-2 and Heart Diseases
 Lung Diseases Antibodies  >16 publications with MAPKAPK-2 and Lung Diseases
 Fibrosis Antibodies  >15 publications with MAPKAPK-2 and Fibrosis
 Kidney Diseases Antibodies  >10 publications with MAPKAPK-2 and Kidney Diseases
 Adenocarcinoma Antibodies  >10 publications with MAPKAPK-2 and Adenocarcinoma
 Hypertrophy Antibodies  >9 publications with MAPKAPK-2 and Hypertrophy
 Neoplasms, Experimental Antibodies  >9 publications with MAPKAPK-2 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >102 publications with MAPKAPK-2 and Blood
 Muscle Antibodies  >76 publications with MAPKAPK-2 and Muscle
 Heart Antibodies  >48 publications with MAPKAPK-2 and Heart
 Lung Antibodies  >32 publications with MAPKAPK-2 and Lung
 Brain Antibodies  >31 publications with MAPKAPK-2 and Brain
 Bone Antibodies  >30 publications with MAPKAPK-2 and Bone
 Bone Marrow Antibodies  >19 publications with MAPKAPK-2 and Bone Marrow
 Skin Antibodies  >18 publications with MAPKAPK-2 and Skin
 Kidney Antibodies  >17 publications with MAPKAPK-2 and Kidney
 Liver Antibodies  >13 publications with MAPKAPK-2 and Liver
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