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anti-MAPRE1 antibody :: Rabbit MAPRE1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127626
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAPRE1, Polyclonal Antibody

 Also Known As   

MAPRE1 Polyclonal Antibody

 Product Synonym Names    EB1: MAPRE1; EB1; MGC117374; MGC129946
 Product Gene Name   

anti-MAPRE1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603108
 3D Structure    ModBase 3D Structure for Q15691
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Fusion protein of human MAPRE1
 Calculated Molecular Weight    30kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-MAPRE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MAPRE1 antibody

   EB1 (end-binding protein 1) is a microtubule associated protein (1). EB1 localizes to the growing ends of microtubules, the centrosome and the mitotic spindle (2-4). EB1 is also found to associate with the adenomatous polyposis coli (APC) protein (5). Recent studies also suggest that EB1 plays a role in microtubule-based transport (6).
 Product Categories/Family for anti-MAPRE1 antibody    Polyclonal
 Applications Tested/Suitable for anti-MAPRE1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-MAPRE1 antibody    WB: 1:500 - 1:1000
IHC: 1:50 - 1:100
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 Western Blot (WB) of anti-MAPRE1 antibody    Western blot analysis of extracts of various cell lines, using MAPRE1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.
anti-MAPRE1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MAPRE1. It may not necessarily be applicable to this product.
 NCBI GI #    20138589
 NCBI GeneID    22919
 NCBI Accession #    Q15691.3 [Other Products]
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 UniProt Primary Accession #    Q15691 [Other Products]
 UniProt Secondary Accession #    Q3KQS8; B2R6I7; E1P5M8 [Other Products]
 UniProt Related Accession #    Q15691 [Other Products]
 Molecular Weight    268
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 NCBI Official Full Name    Microtubule-associated protein RP/EB family member 1
 NCBI Official Synonym Full Names    microtubule-associated protein, RP/EB family, member 1
 NCBI Official Symbol    MAPRE1 [Similar Products]
 NCBI Official Synonym Symbols   
EB1
[Similar Products]
 NCBI Protein Information    microtubule-associated protein RP/EB family member 1; end-binding protein 1; APC-binding protein EB1; adenomatous polyposis coli-binding protein EB1
 UniProt Protein Name    Microtubule-associated protein RP/EB family member 1
 UniProt Synonym Protein Names   
APC-binding protein EB1; End-binding protein 1; EB1
 Protein Family    Microtubule-associated protein RP/EB family
 UniProt Gene Name    MAPRE1 [Similar Products]
 UniProt Synonym Gene Names    EB1 [Similar Products]
 UniProt Entry Name    MARE1_HUMAN
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 NCBI Summary for MAPRE1    The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MAPRE1    EB1: a microtubule-associated protein of the RP/EB family. Binds to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. Localizes to microtubules, especially the growing ends, in interphase cells. Associates with the centrosomes and spindle microtubules during mitosis. Also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. May be involved in the regulation of microtubule structures and chromosome stability.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q11.1-q11.23

Cellular Component: Golgi apparatus; centrosome; microtubule; cell projection membrane; cytoplasmic microtubule; cytoplasm; cortical microtubule cytoskeleton; spindle; cytosol

Molecular Function: protein C-terminus binding; microtubule plus-end binding; protein binding

Biological Process: mitosis; cell proliferation; cell division; organelle organization and biogenesis; negative regulation of microtubule polymerization; mitotic cell cycle; G2/M transition of mitotic cell cycle
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 Research Articles on MAPRE1    1. EB1 has a role in linking AIM2 inflammasomes with autophagy-dependent secretion
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAPRE1 antibodyPathways associated with anti-MAPRE1 antibody
 Reference Product  PubMed Publications
 APC antibody  >13 publications with MAPRE1 and APC
 AURKB antibody  >3 publications with MAPRE1 and AURKB
 CLASP1 antibody  >2 publications with MAPRE1 and CLASP1
 KIF2C antibody  >2 publications with MAPRE1 and KIF2C
 CLASP2 antibody  >1 publications with MAPRE1 and CLASP2
 Products by Pathway  Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
Diseases associated with anti-MAPRE1 antibodyOrgans/Tissues associated with anti-MAPRE1 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >7 publications with MAPRE1 and Carcinoma
 Nervous System Diseases Antibodies  >3 publications with MAPRE1 and Nervous System Diseases
 Adenocarcinoma Antibodies  >3 publications with MAPRE1 and Adenocarcinoma
 Brain Diseases Antibodies  >2 publications with MAPRE1 and Brain Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with MAPRE1 and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >1 publications with MAPRE1 and Neoplasms, Experimental
 Fibrosis Antibodies  >1 publications with MAPRE1 and Fibrosis
 Fetal Death Antibodies  >1 publications with MAPRE1 and Fetal Death
 Esophageal Neoplasms Antibodies  >1 publications with MAPRE1 and Esophageal Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with MAPRE1 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with MAPRE1 and Blood
 Brain Antibodies  >5 publications with MAPRE1 and Brain
 Heart Antibodies  >4 publications with MAPRE1 and Heart
 Vascular Antibodies  >3 publications with MAPRE1 and Vascular
 Lung Antibodies  >3 publications with MAPRE1 and Lung
 Muscle Antibodies  >3 publications with MAPRE1 and Muscle
 Kidney Antibodies  >2 publications with MAPRE1 and Kidney
 Liver Antibodies  >2 publications with MAPRE1 and Liver
 Skin Antibodies  >2 publications with MAPRE1 and Skin
 Intestine Antibodies  >1 publications with MAPRE1 and Intestine
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