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anti-MAPT antibody :: Rabbit anti-Human, Mouse MAPT Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7049571
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAPT, Polyclonal Antibody

★Popular Item★
 Also Known As   

MAPT Antibody

 Product Synonym Names    Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; MAPT; MAPTL; MTBT1; TAU
 Product Gene Name   

anti-MAPT antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    J03778 mRNA
 3D Structure    ModBase 3D Structure for P10636
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Microtubule-associated protein tau protein (33-166AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1995 / sc-1996 / sc-5587
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MAPT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MAPT antibody

   Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
 Applications Tested/Suitable for anti-MAPT antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-MAPT antibody    WB: 1: 1000-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Western Blot (WB) of anti-MAPT antibody    Western Blot
Positive WB detected in:SH-SY5Y whole cell lysate,Mouse heart tissue
All lanes: MAPT antibody at 3.25ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 79,37,33,40,43,41,46,81 kDa
Observed band size: 79,50,36 kDa

anti-MAPT antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MAPT antibody    Immunohistochemistry of paraffin-embedded human brain tissue using MBS7049571 at dilution of 1:100
anti-MAPT antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-MAPT antibody    Immunofluorescent analysis of HepG2 cells using MBS7049571 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-MAPT antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MAPT. It may not necessarily be applicable to this product.
 NCBI GI #    294862258
 NCBI GeneID    4137
 NCBI Accession #    NP_001116538.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001123066.3 [Other Products]
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 UniProt Primary Accession #    P10636 [Other Products]
 UniProt Secondary Accession #    P18518; Q14799; Q15549; Q15550; Q15551; Q1RMF6; Q53YB1; Q5CZI7; Q5XWF0; Q6QT54; Q9UDJ3 [Other Products]
 UniProt Related Accession #    P10636 [Other Products]
 Molecular Weight    80,941 Da
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 NCBI Official Full Name    microtubule-associated protein tau isoform 6
 NCBI Official Synonym Full Names    microtubule associated protein tau
 NCBI Official Symbol    MAPT [Similar Products]
 NCBI Official Synonym Symbols   
TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
[Similar Products]
 NCBI Protein Information    microtubule-associated protein tau
 UniProt Protein Name    Microtubule-associated protein tau
 UniProt Synonym Protein Names   
Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
 Protein Family    Microtubule-associated protein
 UniProt Gene Name    MAPT [Similar Products]
 UniProt Synonym Gene Names    MAPTL; MTBT1; TAU; PHF-tau [Similar Products]
 UniProt Entry Name    TAU_HUMAN
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 NCBI Summary for MAPT    This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MAPT    Tau: a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.1

Cellular Component: axon; cell soma; cytosol; dendrite; growth cone; membrane; nucleus; plasma membrane; tubulin complex

Molecular Function: actin binding; apolipoprotein binding; DNA binding; enzyme binding; Hsp90 protein binding; microtubule binding; protein binding; protein phosphatase 2A binding; receptor agonist activity; SH3 domain binding

Biological Process: astrocyte activation; axon transport of mitochondrion; caspase activation; cytoplasmic microtubule organization and biogenesis; intracellular distribution of mitochondria; memory; microglial cell activation; microtubule cytoskeleton organization and biogenesis; negative regulation of kinase activity; neurite development; positive regulation of axon extension; positive regulation of microtubule polymerization; positive regulation of superoxide release; protein oligomerization; regulation of autophagy; regulation of calcium-mediated signaling; synapse organization and biogenesis

Disease: Frontotemporal Dementia; Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related; Parkinson Disease, Late-onset; Parkinson-dementia Syndrome; Pick Disease Of Brain; Supranuclear Palsy, Progressive, 1
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 Research Articles on MAPT    1. These results indicate that pseudo-acetylation of the single K280 residue is sufficient to exacerbate Tau neurotoxicity in vivo, suggesting that acetylated K280-Tau species contribute to the pathological events leading to neurodegeneration in Alzheimer's disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAPT antibodyPathways associated with anti-MAPT antibody
 Reference Product  PubMed Publications
 SNCA antibody  >106 publications with MAPT and SNCA
 GSK3B antibody  >72 publications with MAPT and GSK3B
 CDK5 antibody  >40 publications with MAPT and CDK5
 FYN antibody  >10 publications with MAPT and FYN
 UBC antibody  >4 publications with MAPT and UBC
 STUB1 antibody  >4 publications with MAPT and STUB1
 MAPK8 antibody  >3 publications with MAPT and MAPK8
 YWHAZ antibody  >2 publications with MAPT and YWHAZ
 MARK2 antibody  >2 publications with MAPT and MARK2
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway antibodies  Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 Copper Homeostasis Pathway antibodies  Copper Homeostasis Pathway Diagram
 IL-2 Signaling Pathway antibodies  IL-2 Signaling Pathway Diagram
Diseases associated with anti-MAPT antibodyOrgans/Tissues associated with anti-MAPT antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1524 publications with MAPT and Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >1409 publications with MAPT and Neurodegenerative Diseases
 Brain Diseases Antibodies  >1387 publications with MAPT and Brain Diseases
 Dementia Antibodies  >1269 publications with MAPT and Dementia
 Tauopathies Antibodies  >1049 publications with MAPT and Tauopathies
 Alzheimer Disease Antibodies  >849 publications with MAPT and Alzheimer Disease
 Frontotemporal Dementia Antibodies  >483 publications with MAPT and Frontotemporal Dementia
 Movement Disorders Antibodies  >341 publications with MAPT and Movement Disorders
 Disease Models, Animal Antibodies  >257 publications with MAPT and Disease Models, Animal
 Parkinsonian Disorders Antibodies  >253 publications with MAPT and Parkinsonian Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1129 publications with MAPT and Brain
 Nerve Antibodies  >290 publications with MAPT and Nerve
 Vascular Antibodies  >47 publications with MAPT and Vascular
 Ganglia Antibodies  >41 publications with MAPT and Ganglia
 Muscle Antibodies  >30 publications with MAPT and Muscle
 Eye Antibodies  >27 publications with MAPT and Eye
 Embryonic Tissue Antibodies  >13 publications with MAPT and Embryonic Tissue
 Kidney Antibodies  >7 publications with MAPT and Kidney
 Lung Antibodies  >5 publications with MAPT and Lung
 Bone Antibodies  >5 publications with MAPT and Bone
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