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anti-MARCKS antibody :: Rabbit anti-Rat MARCKS Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS502070
Testing Data
Unit / Price
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 Product Name   

MARCKS, Polyclonal Antibody

 Also Known As   


 Product Gene Name   

anti-MARCKS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 20; NC_005119.3 (44693252..44698950). Location: chromosome: 20
 3D Structure    ModBase 3D Structure for P30009
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Rat
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 Specificity    Specific for the ~80k MARCKS protein
 Purity/Purification    Neat Serum (Unpurified neat serum.)
 Form/Format    100 ul neat serum.
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 Antigen    Recombinant MARCKS expressed in and purified from E. coli.
 Immunogen Information    Recombinant protein expressed in and purified from E. coli
 Immunogen Species    Rat
 Species Reactivity Note    The antibody has been directly tested for reactivity in rat. It is expected that it will work on other mammalian tissues.
 Biological Significance    Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) is a major substrate for phosphorylation by protein kinase C (PKC) (Ouimet et al.,1990) and is concentrated in synapses of neurons. It appears to function in synaptic vesicle cycling and has been shown to bind both actin and calmodulin in vitro (Hartwig et al. 1992). Deletion of the MARCKS gene in mice results in embryonic brain defects and death (Stumpo et al. 1995). MARCKS is a member of a family of calmodulin binding proteins and phosphorylation of Ser152/156 modulates the binding of MARCKS to calmodulin (Verghese et al., 1994).
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 Preparation and Storage    For long term storage -20 degree C is recommended. Stable at -20 degree C for at least 1 year.
 Other Notes    Small volumes of anti-MARCKS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MARCKS antibody

   Rabbit polyclonal antibody
 Applications Tested/Suitable for anti-MARCKS antibody   

Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-MARCKS antibody    Quality Control: Western blots performed on each lot.
WB: 1:10,000
IF: 1:500
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 Testing Data of anti-MARCKS antibody    anti-MARCKS antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for MARCKS. It may not necessarily be applicable to this product.
 NCBI GI #    266495
 NCBI GeneID    25603
 NCBI Accession #    P30009.2 [Other Products]
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 UniProt Primary Accession #    P30009 [Other Products]
 UniProt Secondary Accession #    P20468 [Other Products]
 UniProt Related Accession #    P30009 [Other Products]
 Molecular Weight    80
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 NCBI Official Full Name    Myristoylated alanine-rich C-kinase substrate
 NCBI Official Synonym Full Names    myristoylated alanine rich protein kinase C substrate
 NCBI Official Symbol    Marcks [Similar Products]
 NCBI Official Synonym Symbols   
KINC; Macs
[Similar Products]
 NCBI Protein Information    myristoylated alanine-rich C-kinase substrate; protein kinase C substrate 80 kDa protein; Myristoylated alanine-rich protein kinase C substrate
 UniProt Protein Name    Myristoylated alanine-rich C-kinase substrate
 UniProt Synonym Protein Names   
Protein kinase C substrate 80 kDa protein
 Protein Family    MARCKS-related protein
 UniProt Gene Name    Marcks [Similar Products]
 UniProt Synonym Gene Names    Macs; MARCKS [Similar Products]
 UniProt Entry Name    MARCS_RAT
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 NCBI Summary for MARCKS    protein kinase C (PKC) substrate and scaffolding protein [RGD, Feb 2006]
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 UniProt Comments for MARCKS    Function: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

Subcellular location: Cytoplasm › cytoskeleton

Probable. Membrane; Lipid-anchor

By similarity.

Tissue specificity: Highest levels found in spleen and brain. Intermediate levels seen in thymus, ovary, lung and heart. Very low levels seen in kidney, skeletal muscle and liver. Ref.3

Post-translational modification: Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.

Sequence similarities: Belongs to the MARCKS family.
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Product References and Citations for anti-MARCKS antibody

   • Ouimet CC, Wang JKT, Walaas SI, Albert KA, Greengard P (1990) Localization of the MARCKS (87 kDa) protein, a major specific substrate for protein kinase C, in rat brain. J Neurosci 10:1683-1698.
• Hartwig JH, Thelen M, Rosen A, Janmey PA, Nairn AC and Aderem A. (1992) MARCKS is an a ctin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature 356: 618-622
• Stumpo DJ, Bock CB, Tuttle JS and Blackshear PJ. (1995) MARCKS deficiency in mice leads to abnormal brain development and perinatal death. Proc. Nat. Acad. Sci. 92; 944-948.
• Verghese GM, Johnson JD, Vasulka C, Haupt DM, Stumpo DJ, Blackshear PJ (1994) Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein. J Biol Chem 269:9361-9367.
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 Research Articles on MARCKS    1. In spermatozoa, as in chromatoid body, BASP1 and MARCKS may bind Ca(2+)-calmodulin and therefore contribute to the activation of calcium-dependent biochemical processes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-MARCKS antibodyOrgans/Tissues associated with anti-MARCKS antibody
 Products by Pathway  Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >221 publications with MARCKS and Brain
 Nerve Antibodies  >81 publications with MARCKS and Nerve
 Muscle Antibodies  >45 publications with MARCKS and Muscle
 Lung Antibodies  >30 publications with MARCKS and Lung
 Embryonic Tissue Antibodies  >21 publications with MARCKS and Embryonic Tissue
 Eye Antibodies  >16 publications with MARCKS and Eye
 Heart Antibodies  >16 publications with MARCKS and Heart
 Pancreas Antibodies  >9 publications with MARCKS and Pancreas
 Ovary Antibodies  >8 publications with MARCKS and Ovary
 Dorsal Root Ganglion Antibodies  >4 publications with MARCKS and Dorsal Root Ganglion
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