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anti-MAVS antibody :: Rabbit anti-Human, Mouse MAVS Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1499447
Western Blot (WB)
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAVS, Polyclonal Antibody

★Popular Item★
 Also Known As   

MAVS Antibody

 Product Synonym Names    MAVS; CARD adapter inducing interferon beta; Cardif; Interferon beta promoter stimulator protein 1; IPS-1; Putative NF-kappa-B-activating protein 031N; Virus-induced-signaling adapter; VISA; MAVS; IPS1; KIAA1271; VISA
 Product Gene Name   

anti-MAVS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609676
 3D Structure    ModBase 3D Structure for Q7Z434
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Mitochondrial antiviral-signaling protein(1-65aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-70096 / sc-68926
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MAVS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MAVS antibody

   Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
 Applications Tested/Suitable for anti-MAVS antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-MAVS antibody    Recommended dilution: WB:1:500-2000
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 Western Blot (WB) of anti-MAVS antibody    Western blot
All lanes: MAVS antibody at 2ug/ml
Lane 1:mouse heart tissue
Lane 2:jurkat whole cell lysate
Lane 3:293T whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 57,16,18,41,15 kDa
Observed band size: 57 kDa

anti-MAVS antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MAVS. It may not necessarily be applicable to this product.
 NCBI GI #    330688443
 NCBI GeneID    57506
 NCBI Accession #    NP_001193420.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001206491.1 [Other Products]
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 UniProt Primary Accession #    Q7Z434 [Other Products]
 UniProt Secondary Accession #    Q2HWT5; Q3I0Y2; Q5T7I6; Q86VY7; Q9H1H3; Q9H4Y1; A8K6X0; B2BD33; B2BD34; F5H6C8; M1P2Z0 [Other Products]
 UniProt Related Accession #    Q7Z434 [Other Products]
 Molecular Weight    15,012 Da
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 NCBI Official Full Name    mitochondrial antiviral-signaling protein isoform 2
 NCBI Official Synonym Full Names    mitochondrial antiviral signaling protein
 NCBI Official Symbol    MAVS [Similar Products]
 NCBI Official Synonym Symbols   
IPS1; VISA; IPS-1; CARDIF
[Similar Products]
 NCBI Protein Information    mitochondrial antiviral-signaling protein
 UniProt Protein Name    Mitochondrial antiviral-signaling protein
 UniProt Synonym Protein Names   
CARD adapter inducing interferon beta; Cardif; Interferon beta promoter stimulator protein 1; IPS-1; Putative NF-kappa-B-activating protein 031N; Virus-induced-signaling adapter; VISA
 Protein Family    Mitochondrial antiviral-signaling protein
 UniProt Gene Name    MAVS [Similar Products]
 UniProt Synonym Gene Names    IPS1; KIAA1271; VISA; MAVS; Cardif; IPS-1; VISA [Similar Products]
 UniProt Entry Name    MAVS_HUMAN
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 NCBI Summary for MAVS    This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
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 UniProt Comments for MAVS    MAVS: Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. Interacts with DDX58/RIG-I, IFIH1/MDA5, TRAF2 and TRAF6. May interact with IRF3, FADD, RIPK1, CHUK and IKBKB. Does not interact with TBK1. Interacts with and is cleaved by HCV and hepatitis GB virus B NS3/4A proteases. Interacts with and is cleaved by HHAV protein 3ABC. Interacts with NLRX1. Interaction with NLRX1 requires the CARD domain. Interacts with PSMA7. Interacts with TRAFD1. Interacts (via C-terminus) with PCBP2 in a complex containing MAVS/IPS1, PCBP2 and ITCH. Interacts with CYLD. Interacts with SRC. Interacts with DHX58/LGP2 and IKBKE. Present in T-cells, monocytes, epithelial cells and hepatocytes. Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: integral to membrane; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; peroxisomal membrane

Molecular Function: CARD domain binding; protein binding; protein kinase binding; signal transducer activity

Biological Process: activation of innate immune response; defense response to bacterium; defense response to virus; innate immune response; negative regulation of interferon type I production; negative regulation of viral genome replication; positive regulation of defense response to virus by host; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of interleukin-8 production; positive regulation of protein amino acid phosphorylation; positive regulation of protein import into nucleus, translocation; positive regulation of transcription factor activity; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; signal transduction; viral reproduction
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 Research Articles on MAVS    1. During Crimean-Congo hemorrhagic fever virus infection, RIG-I mediated a type I interferon response via MAVS.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAVS antibodyPathways associated with anti-MAVS antibody
 Reference Product  PubMed Publications
 IRF3 antibody  >117 publications with MAVS and IRF3
 DDX58 antibody  >103 publications with MAVS and DDX58
 TBK1 antibody  >55 publications with MAVS and TBK1
 IFIH1 antibody  >43 publications with MAVS and IFIH1
 TRAF3 antibody  >27 publications with MAVS and TRAF3
 TRAF6 antibody  >16 publications with MAVS and TRAF6
 NLRX1 antibody  >15 publications with MAVS and NLRX1
 ATG5 antibody  >4 publications with MAVS and ATG5
 TMEM173 antibody  >2 publications with MAVS and TMEM173
 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
Diseases associated with anti-MAVS antibodyOrgans/Tissues associated with anti-MAVS antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >50 publications with MAVS and Inflammation
 Death Antibodies  >49 publications with MAVS and Death
 Liver Diseases Antibodies  >36 publications with MAVS and Liver Diseases
 Necrosis Antibodies  >34 publications with MAVS and Necrosis
 Immune System Diseases Antibodies  >22 publications with MAVS and Immune System Diseases
 Nervous System Diseases Antibodies  >18 publications with MAVS and Nervous System Diseases
 Disease Models, Animal Antibodies  >18 publications with MAVS and Disease Models, Animal
 Kidney Diseases Antibodies  >6 publications with MAVS and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >6 publications with MAVS and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >4 publications with MAVS and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >40 publications with MAVS and Blood
 Liver Antibodies  >34 publications with MAVS and Liver
 Lung Antibodies  >29 publications with MAVS and Lung
 Bone Antibodies  >17 publications with MAVS and Bone
 Spleen Antibodies  >14 publications with MAVS and Spleen
 Bone Marrow Antibodies  >13 publications with MAVS and Bone Marrow
 Brain Antibodies  >12 publications with MAVS and Brain
 Heart Antibodies  >10 publications with MAVS and Heart
 Muscle Antibodies  >10 publications with MAVS and Muscle
 Kidney Antibodies  >10 publications with MAVS and Kidney
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