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anti-MB21D1 antibody :: Rabbit MB21D1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9128631
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MB21D1, Polyclonal Antibody

★Popular Item★
 Also Known As   

MB21D1 Polyclonal Antibody

 Product Synonym Names    MB21D1; C6orf150; cGAS; h-cGAS; cyclic GMP-AMP synthase
 Product Gene Name   

anti-MB21D1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    350-522
 OMIM    613973
 3D Structure    ModBase 3D Structure for Q8N884
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
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 Immunogen    Recominant fusion protein containing a sequence corresponding to amino acids 350-522 of human MB21D1(NP_612450.2).
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 Preparation and Storage    Store at -20C. Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-MB21D1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MB21D1 antibody   

Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-MB21D1 antibody    WB 1:500 - 1:2000
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 Western Blot (WB) of anti-MB21D1 antibody    Western blot analysis of extracts of various cell lines" using MB21D1 antibody at 1 :1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+l) at 1 :10000 dilution. Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit
Exposure time: 10s.
anti-MB21D1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence of anti-MB21D1 antibody    Immunofluorescence analysis of NIH/3T3 cells using MB21D1 antibody at dilution of 1 :100. Blue: DAptfor nuclear staining.
anti-MB21D1 antibody Immunofluorescence image
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NCBI/Uniprot data below describe general gene information for MB21D1. It may not necessarily be applicable to this product.
 NCBI GI #    115511030
 NCBI GeneID    115004
 NCBI Accession #    NP_612450.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_138441.2 [Other Products]
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 UniProt Primary Accession #    Q8N884 [Other Products]
 UniProt Secondary Accession #    Q14CV6; Q32NC9; Q5SWL0; Q5SWL1; Q96E45; L0L2J9 [Other Products]
 UniProt Related Accession #    Q8N884 [Other Products]
 Molecular Weight    Calculated: 49 kDa/58 kDa
Observed: 59 kDa
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 NCBI Official Full Name    cyclic GMP-AMP synthase
 NCBI Official Synonym Full Names    Mab-21 domain containing 1
 NCBI Official Symbol    MB21D1 [Similar Products]
 NCBI Official Synonym Symbols   
cGAS; h-cGAS; C6orf150
[Similar Products]
 NCBI Protein Information    cyclic GMP-AMP synthase
 UniProt Protein Name    Cyclic GMP-AMP synthase
 UniProt Synonym Protein Names   
Mab-21 domain-containing protein 1
 Protein Family    Cyclic GMP-AMP synthase
 UniProt Gene Name    MB21D1 [Similar Products]
 UniProt Synonym Gene Names    C6orf150; cGAMP synthase; cGAS; h-cGAS [Similar Products]
 UniProt Entry Name    CGAS_HUMAN
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 UniProt Comments for MB21D1    MB21D1: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.

Protein type: Enzyme, cellular metabolism; EC

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: cytosol

Molecular Function: DNA binding; GTP binding; metal ion binding; ATP binding

Biological Process: cyclic nucleotide biosynthetic process; positive regulation of interferon type I production; innate immune response; positive regulation of defense response to virus by host; activation of innate immune response; defense response to virus
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 Research Articles on MB21D1    1. Study found that PQBP1 directly binds to reverse-transcribed HIV-1 DNA and interacts with cGAS to initiate an IRF3-dependent innate response.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MB21D1 antibodyPathways associated with anti-MB21D1 antibody
 Reference Product  PubMed Publications
 TREX1 antibody  >3 publications with MB21D1 and TREX1
 TMEM173 antibody  >3 publications with MB21D1 and TMEM173
 DDX41 antibody  >2 publications with MB21D1 and DDX41
 MOV10 antibody  >1 publications with MB21D1 and MOV10
 FAM46C antibody  >1 publications with MB21D1 and FAM46C
 MCOLN2 antibody  >1 publications with MB21D1 and MCOLN2
 DDX60 antibody  >1 publications with MB21D1 and DDX60
 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 STING Mediated Induction Of Host Immune Responses Pathway antibodies  STING Mediated Induction Of Host Immune Responses Pathway Diagram
Diseases associated with anti-MB21D1 antibodyOrgans/Tissues associated with anti-MB21D1 antibody
 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >2 publications with MB21D1 and Neoplasms, Experimental
 Neurobehavioral Manifestations Antibodies  >1 publications with MB21D1 and Neurobehavioral Manifestations
 Poisoning Antibodies  >1 publications with MB21D1 and Poisoning
 Mitochondrial Diseases Antibodies  >1 publications with MB21D1 and Mitochondrial Diseases
 Necrosis Antibodies  >1 publications with MB21D1 and Necrosis
 Inflammation Antibodies  >1 publications with MB21D1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with MB21D1 and Blood
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