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anti-MBTPS1 antibody :: Rabbit anti-Human, Mouse MBTPS1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7046496
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MBTPS1, Polyclonal Antibody

★Popular Item★
 Also Known As   

MBTPS1 Antibody

 Product Synonym Names    Membrane-bound transcription factor site-1 protease; Endopeptidase S1P; Subtilisin/kexin-isozyme 1; SKI-1; MBTPS1; KIAA0091; S1P; SKI1
 Product Gene Name   

anti-MBTPS1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603355
 3D Structure    ModBase 3D Structure for Q14703
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Membrane-bound transcription factor site-1 protease protein (C-250AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9785 / sc-9786 / sc-20757
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MBTPS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MBTPS1 antibody

   Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.
 Applications Tested/Suitable for anti-MBTPS1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-MBTPS1 antibody    Western blot
All lanes: MBTPS1antibody at 4.06ug/ml+ Mouse kidney tissue
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 118 kDa
Observed band size: 118 kDa

anti-MBTPS1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MBTPS1 antibody    Immunohistochemistry of paraffin-embedded human lung tissue using MBS7046496 at dilution 1:100
anti-MBTPS1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-MBTPS1 antibody    Immunohistochemistry of paraffin-embedded human small intestine using MBS7046496 at dilution 1:100
anti-MBTPS1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MBTPS1. It may not necessarily be applicable to this product.
 NCBI GI #    4506775
 NCBI GeneID    8720
 NCBI Accession #    NP_003782.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003791.3 [Other Products]
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 UniProt Primary Accession #    Q14703 [Other Products]
 UniProt Secondary Accession #    Q24JQ2; Q9UF67; A8K6V8 [Other Products]
 UniProt Related Accession #    Q14703 [Other Products]
 Molecular Weight    117,749 Da
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 NCBI Official Full Name    membrane-bound transcription factor site-1 protease preproprotein
 NCBI Official Synonym Full Names    membrane bound transcription factor peptidase, site 1
 NCBI Official Symbol    MBTPS1 [Similar Products]
 NCBI Official Synonym Symbols   
S1P; PCSK8; SKI-1
[Similar Products]
 NCBI Protein Information    membrane-bound transcription factor site-1 protease
 UniProt Protein Name    Membrane-bound transcription factor site-1 protease
 UniProt Synonym Protein Names   
Endopeptidase S1P; Subtilisin/kexin-isozyme 1; SKI-1
 Protein Family    Membrane-bound transcription factor site-1 protease
 UniProt Gene Name    MBTPS1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0091; S1P; SKI1; SKI-1 [Similar Products]
 UniProt Entry Name    MBTP1_HUMAN
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 NCBI Summary for MBTPS1    This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014]
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 UniProt Comments for MBTPS1    MBTPS1: Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His- Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Belongs to the peptidase S8 family.

Protein type: Protease; EC 3.4.21.112; Endoplasmic reticulum; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16q24

Cellular Component: endoplasmic reticulum lumen; Golgi membrane

Molecular Function: serine-type endopeptidase activity

Biological Process: lysosome organization and biogenesis; membrane protein intracellular domain proteolysis; proteolysis
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 Research Articles on MBTPS1    1. primordial SKI-1/S1P likely contained a simpler prodomain consisting of the highly conserved AB fragment that represents an independent folding unit
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-MBTPS1 antibodyDiseases associated with anti-MBTPS1 antibody
 Products by Pathway  Pathway Diagram
 ATF6-alpha Activates Chaperones Pathway antibodies  ATF6-alpha Activates Chaperones Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Regulation Of Cholesterol Biosynthesis By SREBP (SREBF) Pathway antibodies  Regulation Of Cholesterol Biosynthesis By SREBP (SREBF) Pathway Diagram
 SREBP Signalling Pathway antibodies  SREBP Signalling Pathway Diagram
 Unfolded Protein Response (UPR) Pathway antibodies  Unfolded Protein Response (UPR) Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >3 publications with MBTPS1 and Liver Diseases
 Fatty Liver Antibodies  >3 publications with MBTPS1 and Fatty Liver
 Disease Models, Animal Antibodies  >3 publications with MBTPS1 and Disease Models, Animal
 Hepatomegaly Antibodies  >2 publications with MBTPS1 and Hepatomegaly
 Cardiovascular Diseases Antibodies  >2 publications with MBTPS1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >2 publications with MBTPS1 and Atherosclerosis
 Lung Diseases Antibodies  >1 publications with MBTPS1 and Lung Diseases
 Fibrosis Antibodies  >1 publications with MBTPS1 and Fibrosis
 Necrosis Antibodies  >1 publications with MBTPS1 and Necrosis
 Inflammation Antibodies  >1 publications with MBTPS1 and Inflammation
Organs/Tissues associated with anti-MBTPS1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with MBTPS1 and Blood
 Liver Antibodies  >4 publications with MBTPS1 and Liver
 Muscle Antibodies  >4 publications with MBTPS1 and Muscle
 Bone Antibodies  >4 publications with MBTPS1 and Bone
 Mammary Gland Antibodies  >2 publications with MBTPS1 and Mammary Gland
 Vascular Antibodies  >2 publications with MBTPS1 and Vascular
 Bone Marrow Antibodies  >2 publications with MBTPS1 and Bone Marrow
 Skin Antibodies  >1 publications with MBTPS1 and Skin
 Intestine Antibodies  >1 publications with MBTPS1 and Intestine
 Lung Antibodies  >1 publications with MBTPS1 and Lung
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