NP_002377.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,706 Da
NCBI Official Full Name
melanocyte-stimulating hormone receptor
NCBI Official Synonym Full Names
melanocortin 1 receptor
NCBI Protein Information
melanocyte-stimulating hormone receptor
UniProt Protein Name
Melanocyte-stimulating hormone receptor
UniProt Synonym Protein Names
Melanocortin receptor 1; MC1-R
UniProt Synonym Gene Names
NCBI Summary for MC1R
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]
UniProt Comments for MC1R
MC1R: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Genetic variations in MC1R are a cause of susceptibility to cutaneous malignant melanoma type 5 (CMM5). Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. Belongs to the G-protein coupled receptor 1 family.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: melanocortin receptor activity; melanocyte stimulating hormone receptor activity; peptide receptor activity, G-protein coupled; protein binding; ubiquitin protein ligase binding
Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; multicellular organismal development; negative regulation of tumor necrosis factor production; pigmentation; positive regulation of cAMP biosynthetic process; positive regulation of protein kinase B signaling cascade; positive regulation of transcription from RNA polymerase II promoter; UV protection
Disease: Albinism, Oculocutaneous, Type Ii; Increased Analgesia From Kappa-opioid Receptor Agonist, Female-specific; Melanoma, Cutaneous Malignant, Susceptibility To, 5; Skin/hair/eye Pigmentation, Variation In, 2
Product References and Citations for anti-MC1R antibody
1. Aoki H, Moro O (2002). "Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R)". Life Sci. 71 (18): 2171-9. 2. Mogil JS, Ritchie J, Smith SB, Strasburg K, Kaplan L, Wallace MR, Romberg RR, Bijl H, Sarton EY, Fillingim RB, Dahan A (2005)."Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans". J. Med. Genet. 42 (7): 583-7. 3. Robbins LS, Nadeau JH, Johnson KR, Kelly MA, Roselli-Rehfuss L, Baack E, Mountjoy KG, Cone RD (1993). "Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function.". Cell. 72 (6): 827-834.
Research Articles on MC1R
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Products associated with anti-MC1R antibody
Pathways associated with anti-MC1R antibody
Diseases associated with anti-MC1R antibody
Disease Name |
Pubmed Publications |
Melanoma Antibodies |
>403 publications with MC1R and Melanoma |
Carcinoma Antibodies |
>46 publications with MC1R and Carcinoma |
Inflammation Antibodies |
>38 publications with MC1R and Inflammation |
Neoplasms, Experimental Antibodies |
>37 publications with MC1R and Neoplasms, Experimental |
Carcinoma, Basal Cell Antibodies |
>36 publications with MC1R and Carcinoma, Basal Cell |
Necrosis Antibodies |
>14 publications with MC1R and Necrosis |
Vitiligo Antibodies |
>12 publications with MC1R and Vitiligo |
Oculocutaneous albinism type 2 Antibodies |
>6 publications with MC1R and Oculocutaneous albinism type 2 |
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 1 Antibodies |
>5 publications with MC1R and MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 1 |
Weight Loss Antibodies |
>5 publications with MC1R and Weight Loss |
Organs/Tissues associated with anti-MC1R antibody
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