NP_005903.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,943 Da
NCBI Official Full Name
melanocortin receptor 4
NCBI Official Synonym Full Names
melanocortin 4 receptor
NCBI Protein Information
melanocortin receptor 4
UniProt Protein Name
Melanocortin receptor 4
UniProt Synonym Gene Names
UniProt Entry Name
MC4R_HUMAN
NCBI Summary for MC4
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]
UniProt Comments for MC4
MC4R: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. A G-protein coupled receptor that stimulates adenylate cyclase. Defects are a cause of autosomal dominant obesity
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1
Chromosomal Location of Human Ortholog: 18q22
Cellular Component: integral to membrane; nucleus; plasma membrane
Molecular Function: melanocortin receptor activity; melanocyte stimulating hormone receptor activity; neuropeptide binding; peptide hormone binding; protein binding; ubiquitin protein ligase binding
Biological Process: diet induced thermogenesis; energy reserve metabolic process; feeding behavior; G-protein signaling, coupled to cAMP nucleotide second messenger; insulin secretion; positive regulation of bone resorption; positive regulation of cAMP biosynthetic process; response to insulin stimulus
Disease: Obesity
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Products associated with anti-MC4 antibody
Diseases associated with anti-MC4 antibody
Organs/Tissues associated with anti-MC4 antibody
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