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anti-MC4R antibody :: Rabbit MC4R Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150230
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MC4R, Polyclonal Antibody

 Also Known As   

MC4R Antibody

 Product Synonym Names    MC4R; Melanocortin receptor 4; MC4-R; melanocortin 4 receptor
 Product Gene Name   

anti-MC4R antibody

[Similar Products]
 Antibody/Peptide Pairs    MC4R peptide (MBS152190) is used for blocking the activity of MC4R antibody (MBS150230)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 601665
 3D Structure    ModBase 3D Structure for P32245
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    MC4R Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    MC4R antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human MC4R.
 Buffer    MC4R Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    MC4R antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-MC4R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MC4R antibody

   MC4R Antibody: The melanocortin-4 receptor (MC4R) is a member of the superfamily of seven transmembrane G-protein coupled receptors that are involved in multiple signal transduction pathways including the cAMP and MAPK signaling pathways. It is thought that the melanocortin system modulates energy expenditure and insulin sensitivity; activation of the MC4R results in the inhibition of c-Jun N-terminal kinase (JNK) activity and promotes insulin signaling. MC4R-null mice display maturity onset obesity characterized by hyperphagia, increased adiposity, hyperinsulinaemia and hyperleptinaemia, suggesting that like other obesity-linked genes such as FTO, PTER, and NPC1, MC4R is a potential candidate target for the treatment of obesity.
 Applications Tested/Suitable for anti-MC4R antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-MC4R antibody    MC4R antibody can be used for detection of MC4R by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-MC4R antibody    Western blot analysis of MC4R in rat brain tissue lysate with MC4R antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
anti-MC4R antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MC4R antibody    Immunohistochemistry of MC4R in human brain tissue with MC4R antibody at 2.5 μg/mL.
anti-MC4R antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-MC4R antibody    Immunofluorescence of MC4R in Human Brain cells with MC4R antibody at 20 μg/mL.
anti-MC4R antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for MC4R. It may not necessarily be applicable to this product.
 NCBI GI #    119508433
 NCBI GeneID    4160
 NCBI Accession #    NP_005903 [Other Products]
 NCBI GenBank Nucleotide #    NM_005912.2 [Other Products]
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 UniProt Primary Accession #    P32245 [Other Products]
 UniProt Secondary Accession #    Q16317; Q3MIJ6; B2RAC3 [Other Products]
 UniProt Related Accession #    P32245 [Other Products]
 Molecular Weight    36,943 Da
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 NCBI Official Full Name    melanocortin receptor 4
 NCBI Official Synonym Full Names    melanocortin 4 receptor
 NCBI Official Symbol    MC4R [Similar Products]
 NCBI Protein Information    melanocortin receptor 4; MC4-R
 UniProt Protein Name    Melanocortin receptor 4
 Protein Family    Melanocortin receptor
 UniProt Gene Name    MC4R [Similar Products]
 UniProt Synonym Gene Names    MC4-R [Similar Products]
 UniProt Entry Name    MC4R_HUMAN
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 NCBI Summary for MC4R    The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]
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 UniProt Comments for MC4R    MC4R: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. A G-protein coupled receptor that stimulates adenylate cyclase. Defects are a cause of autosomal dominant obesity

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22

Cellular Component: integral to membrane; plasma membrane; nucleus

Molecular Function: neuropeptide binding; protein binding; melanocortin receptor activity; ubiquitin protein ligase binding; peptide hormone binding; melanocyte stimulating hormone receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; diet induced thermogenesis; insulin secretion; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; positive regulation of bone resorption; feeding behavior; response to insulin stimulus

Disease: Obesity
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 Research Articles on MC4R    1. We identified differences in the striatal response to food cues between two groups of obese individuals, those with and those without MC4R mutations.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MC4R antibodyPathways associated with anti-MC4R antibody
 Reference Product  PubMed Publications
 POMC antibody  >350 publications with MC4R and POMC
 AGRP antibody  >131 publications with MC4R and AGRP
 MC1R antibody  >75 publications with MC4R and MC1R
 LEP antibody  >24 publications with MC4R and LEP
 CRH antibody  >12 publications with MC4R and CRH
 GLP1R antibody  >3 publications with MC4R and GLP1R
 GHRH antibody  >1 publications with MC4R and GHRH
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with anti-MC4R antibodyOrgans/Tissues associated with anti-MC4R antibody
 Disease Name  Pubmed Publications
 Obesity Antibodies  >625 publications with MC4R and Obesity
 Body Weight Antibodies  >574 publications with MC4R and Body Weight
 Weight Gain Antibodies  >96 publications with MC4R and Weight Gain
 Weight Loss Antibodies  >83 publications with MC4R and Weight Loss
 Hyperphagia Antibodies  >72 publications with MC4R and Hyperphagia
 Insulin Resistance Antibodies  >56 publications with MC4R and Insulin Resistance
 Hyperinsulinism Antibodies  >46 publications with MC4R and Hyperinsulinism
 Hypertension Antibodies  >39 publications with MC4R and Hypertension
 Cardiovascular Diseases Antibodies  >37 publications with MC4R and Cardiovascular Diseases
 Inflammation Antibodies  >34 publications with MC4R and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >299 publications with MC4R and Brain
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