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anti-MCL1 antibody :: Rabbit MCL1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS535177
Western Blot (WB)
Unit / Price
0.1 mg  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MCL1, Polyclonal Antibody

 Also Known As   

MCL1 antibody

 Product Synonym Names    Polyclonal MCL1; Anti-MCL1; MCL 1; BCL2L3; MCL-1; Bcl 2 related protein EAT/mcl1; MCL1; Induced myeloid leukemia cell differentiation protein Mcl 1; BCL2 related; EAT; Myeloid Cell Leukemia 1; Mcl-1
 Product Gene Name   

anti-MCL1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    159552
 3D Structure    ModBase 3D Structure for Q07820
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Dog, Human, Monkey, Pig, Rabbit
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 Purity/Purification    MCL1 antibody was purified by affinity chromatography
 Form/Format    Supplied in PBS buffer with 50% glycerol, pH 7.2, with 1% BSA, and 0.02% NaN3.
 Concentration    0.2 mg/ml (lot specific)
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 Biological Significance    Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
 Immunogen    MCL-1 antibody was raised in rabbit using a synthetic peptide corresponding to residues surrounding amino acid 131 of human Mcl-1 as the immunogen.
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 Preparation and Storage    Aliquot and store at -20 degree C for short term storage, -70 degree C for long-term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-MCL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MCL1 antibody

   Rabbit polyclonal MCL1 antibody
 Product Categories/Family for anti-MCL1 antibody    Cancer
 Applications Tested/Suitable for anti-MCL1 antibody   

Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-MCL1 antibody    IP: 0.5-4 ug/ml
IHC: 10-20 ug/ml
WB: 1 ug/ml
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 Western Blot (WB) of anti-MCL1 antibody    Western Blot analysis of cell lysate using MCL1 antibody at 0.5-4 ug/ml...
anti-MCL1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MCL1. It may not necessarily be applicable to this product.
 NCBI GI #    7582271
 NCBI GeneID    4170
 NCBI Accession #    AAF64255.1 [Other Products]
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 UniProt Primary Accession #    Q07820 [Other Products]
 UniProt Secondary Accession #    Q9HD91; Q9NRQ3; Q9NRQ4; Q9UHR7; Q9UHR8; Q9UHR9; Q9UNJ1; B2R6B2; D3DV03; D3DV04 [Other Products]
 UniProt Related Accession #    Q07820 [Other Products]
 Molecular Weight    28,662 Da
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 NCBI Official Full Name    Mcl-1
 NCBI Official Synonym Full Names    myeloid cell leukemia 1
 NCBI Official Symbol    MCL1 [Similar Products]
 NCBI Official Synonym Symbols   
TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT
[Similar Products]
 NCBI Protein Information    induced myeloid leukemia cell differentiation protein Mcl-1
 UniProt Protein Name    Induced myeloid leukemia cell differentiation protein Mcl-1
 UniProt Synonym Protein Names   
Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT
 Protein Family    Minichromosome loss protein
 UniProt Gene Name    MCL1 [Similar Products]
 UniProt Synonym Gene Names    BCL2L3; Bcl2-L-3 [Similar Products]
 UniProt Entry Name    MCL1_HUMAN
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 NCBI Summary for MCL1    This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
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 UniProt Comments for MCL1    MCL1: a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.

Protein type: Channel, misc.; Apoptosis; Mitochondrial; Inhibitor; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: nucleoplasm; mitochondrial outer membrane; membrane; mitochondrion; mitochondrial matrix; cytoplasm; integral to membrane; cytosol; nucleus

Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; protein channel activity; BH3 domain binding

Biological Process: apoptotic mitochondrial changes; DNA damage response, signal transduction resulting in induction of apoptosis; multicellular organismal development; response to cytokine stimulus; cellular homeostasis; cell fate determination
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 Research Articles on MCL1    1. These results demonstrated that Gos induces apoptosis in MM cells not only through displacing BH3-only proteins from Bcl-2, but also through inhibiting IL-6 signaling, which leads to Bcl-2 dephosphorylation and Mcl-1 downregulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to MCL1 antibody
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Pathways associated with anti-MCL1 antibodyDiseases associated with anti-MCL1 antibody
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 IL-7 Signaling Pathway antibodies  IL-7 Signaling Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >63 publications with MCL1 and Lung Neoplasms
 Necrosis Antibodies  >53 publications with MCL1 and Necrosis
 Breast Neoplasms Antibodies  >46 publications with MCL1 and Breast Neoplasms
 Liver Diseases Antibodies  >43 publications with MCL1 and Liver Diseases
 Neoplasms, Experimental Antibodies  >35 publications with MCL1 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >34 publications with MCL1 and Liver Neoplasms
 Multiple Myeloma Antibodies  >33 publications with MCL1 and Multiple Myeloma
 Carcinoma, Hepatocellular Antibodies  >32 publications with MCL1 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >30 publications with MCL1 and Inflammation
 Pancreatic Neoplasms Antibodies  >22 publications with MCL1 and Pancreatic Neoplasms
Organs/Tissues associated with anti-MCL1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >163 publications with MCL1 and Blood
 Lung Antibodies  >87 publications with MCL1 and Lung
 Liver Antibodies  >75 publications with MCL1 and Liver
 Bone Antibodies  >64 publications with MCL1 and Bone
 Bone Marrow Antibodies  >48 publications with MCL1 and Bone Marrow
 Brain Antibodies  >40 publications with MCL1 and Brain
 Prostate Antibodies  >35 publications with MCL1 and Prostate
 Skin Antibodies  >24 publications with MCL1 and Skin
 Vascular Antibodies  >22 publications with MCL1 and Vascular
 Lymph Node Antibodies  >18 publications with MCL1 and Lymph Node
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