CAA37615.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
Molecular Weight
98,780 Da
NCBI Official Full Name
MCM2
UniProt Protein Name
DNA replication licensing factor MCM2
UniProt Synonym Protein Names
Minichromosome maintenance protein 2
UniProt Entry Name
MCM2_YEAST
UniProt Comments for MCM2
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity; specifically the MCM2-MCM5 association is proposed to be reversible and to mediate a open ring conformation which may facilitate DNA loading. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity. Necessary for cell growth.
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Products associated with anti-MCM2 antibody
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