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anti-MCM6 antibody :: Rabbit MCM6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175395
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MCM6, Polyclonal Antibody

 Also Known As   

Anti-MCM6 antibody

 Product Synonym Names    DNA replication licensing factor MCM6; minichromosome maintenance complex component 6; DNA replication licensing factor MCM6 antibody; MCG40308 antibody; Mcm6 antibody; MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe) antibody; MCM6 minichromosome maintenance deficient 6 antibody; MCM6_HUMAN antibody; Minichromosome maintenance complex component 6 antibody; Minichromosome maintenance deficient(mis5 S. pombe) 6 antibody; Minichromosome maintenance deficient 6 homolog antibody; Minichromosome maintenance protein 6 antibody; Mis5 antibody; MIS5 homolog antibody; p105MCM antibody
 Product Gene Name   

anti-MCM6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601806
 3D Structure    ModBase 3D Structure for Q14566
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence in the middle region of human MCM6 (589-605aa ESEDFIVEQYKHLRQRD), different from the related rat and mouse sequences by one amino acid.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MCM6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MCM6 antibody

   Description: Rabbit IgG polyclonal antibody for DNA replication licensing factor MCM6(MCM6) detection. Tested with WB, IHC-P, IHC-F, ICC in Human, Mouse, Rat.
Background: MCM6(Minichromosome maintenance, s. pombe, homolog of, 6) is a protein that in humans is encoded by the MCM6 gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins(MCM) that are essential for the initiation of eukaryotic genome replication. The MCM genes were originally identified in yeast defective in minichromosome maintenance and have since been shown to play roles in the progression of the cell cycle; many are cell division control genes. The MCM6 gene is mapped on 2q21.3. Mcm 6 has recently been shown to interact strongly Cdt1 at defined residues, by mutating these target residues Wei et al. observed lack of Cdt1 recruitment of Mcm2-7 to the pre-RC. An approximately 200-kb region surrounding the C/T(-13910) polymorphism in MCM6 intron 13 functioned as an enhancer of the lactase gene promoter in intestinal cell culture.
 Applications Tested/Suitable for anti-MCM6 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin, Immunocytochemistry ICC

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 Testing Data of anti-MCM6 antibody    anti-MCM6 antibody Testing Data image
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 Testing Data #2 of anti-MCM6 antibody    anti-MCM6 antibody Testing Data #2 image
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 Testing Data #3 of anti-MCM6 antibody    anti-MCM6 antibody Testing Data #3 image
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 Testing Data #4 of anti-MCM6 antibody    anti-MCM6 antibody Testing Data #4 image
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 Testing Data #5 of anti-MCM6 antibody    anti-MCM6 antibody Testing Data #5 image
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NCBI/Uniprot data below describe general gene information for MCM6. It may not necessarily be applicable to this product.
 NCBI GI #    2497824
 NCBI GeneID    4175
 NCBI Accession #    Q14566.1 [Other Products]
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 UniProt Primary Accession #    Q14566 [Other Products]
 UniProt Secondary Accession #    Q13504; Q99859; B2R6H2 [Other Products]
 UniProt Related Accession #    Q14566 [Other Products]
 Molecular Weight    92,889 Da
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 NCBI Official Full Name    DNA replication licensing factor MCM6
 NCBI Official Synonym Full Names    minichromosome maintenance complex component 6
 NCBI Official Symbol    MCM6 [Similar Products]
 NCBI Official Synonym Symbols   
Mis5; P105MCM; MCG40308
[Similar Products]
 NCBI Protein Information    DNA replication licensing factor MCM6; minichromosome maintenance deficient (mis5, S. pombe) 6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
 UniProt Protein Name    DNA replication licensing factor MCM6
 UniProt Synonym Protein Names   
p105MCM
 Protein Family    DNA replication licensing factor
 UniProt Gene Name    MCM6 [Similar Products]
 UniProt Entry Name    MCM6_HUMAN
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 NCBI Summary for MCM6    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]
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 UniProt Comments for MCM6    MCM6: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Belongs to the MCM family.

Protein type: EC 3.6.4.12; Cell cycle regulation

Chromosomal Location of Human Ortholog: 2q21

Cellular Component: nucleoplasm; MCM complex; nucleus

Molecular Function: ATP-dependent DNA helicase activity; identical protein binding; protein binding; single-stranded DNA binding; ATP binding

Biological Process: DNA unwinding during replication; DNA replication initiation; DNA strand elongation during DNA replication; mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle

Disease: Lactose Intolerance, Adult Type
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 Research Articles on MCM6    1. Mcm2-7 loads onto origins during initiation as a double hexamer, yet does not act as a double-stranded DNA pump during elongation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MCM6 antibodyPathways associated with anti-MCM6 antibody
 Reference Product  PubMed Publications
 MCM2 antibody  >79 publications with MCM6 and MCM2
 MCM4 antibody  >68 publications with MCM6 and MCM4
 MCM7 antibody  >56 publications with MCM6 and MCM7
 MCM3 antibody  >36 publications with MCM6 and MCM3
 MCM5 antibody  >30 publications with MCM6 and MCM5
 CDT1 antibody  >19 publications with MCM6 and CDT1
 CDC45 antibody  >13 publications with MCM6 and CDC45
 GMNN antibody  >3 publications with MCM6 and GMNN
 MCM10 antibody  >3 publications with MCM6 and MCM10
 Products by Pathway  Pathway Diagram
 Activation Of ATR In Response To Replication Stress Pathway antibodies  Activation Of ATR In Response To Replication Stress Pathway Diagram
 Activation Of The Pre-replicative Complex Pathway antibodies  Activation Of The Pre-replicative Complex Pathway Diagram
 Assembly Of The Pre-replicative Complex Pathway antibodies  Assembly Of The Pre-replicative Complex Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
Diseases associated with anti-MCM6 antibodyOrgans/Tissues associated with anti-MCM6 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >13 publications with MCM6 and Carcinoma
 Adenocarcinoma Antibodies  >7 publications with MCM6 and Adenocarcinoma
 Nervous System Diseases Antibodies  >7 publications with MCM6 and Nervous System Diseases
 Lung Neoplasms Antibodies  >7 publications with MCM6 and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >5 publications with MCM6 and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >4 publications with MCM6 and Liver Neoplasms
 Liver Diseases Antibodies  >4 publications with MCM6 and Liver Diseases
 Neoplasms, Experimental Antibodies  >3 publications with MCM6 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >3 publications with MCM6 and Cell Transformation, Neoplastic
 Carcinoma, Hepatocellular Antibodies  >2 publications with MCM6 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19 publications with MCM6 and Blood
 Lung Antibodies  >10 publications with MCM6 and Lung
 Vascular Antibodies  >9 publications with MCM6 and Vascular
 Lymph Antibodies  >7 publications with MCM6 and Lymph
 Liver Antibodies  >7 publications with MCM6 and Liver
 Muscle Antibodies  >6 publications with MCM6 and Muscle
 Lymph Node Antibodies  >6 publications with MCM6 and Lymph Node
 Ovary Antibodies  >4 publications with MCM6 and Ovary
 Bone Antibodies  >4 publications with MCM6 and Bone
 Brain Antibodies  >4 publications with MCM6 and Brain
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