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anti-MCP1 antibody :: Rabbit anti-Rat MCP1 MCP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS535888 anti-MCP1 antibody
Unit / Price
0.05 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MCP1, Polyclonal Antibody

 Also Known As   

MCP1 antibody

 Product Synonym Names    Polyclonal MCP1; Anti-MCP1; JE; Monocyte Chemotactic-1; MCP 1; Mouse; MCP-1; CCL2; MCAF; MCP1
 Product Gene Name   

anti-MCP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    158105
 3D Structure    ModBase 3D Structure for P13500
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Rat MCP1
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 Form/Format    Lyophilized from PBS, pH 7.2.
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 Biological Significance    The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross reacts across species.
 Immunogen    MCP1 antibody was raised in rabbit using highly pure recombinant rat MCP-1(MCAF) as the immunogen.
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 Preparation and Storage    Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-MCP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MCP1 antibody

   Affinity purified Rabbit polyclonal MCP1 antibody
 Product Categories/Family for anti-MCP1 antibody    Cytokines & Growth Factors; Purified Polyclonal Antibodies
 Applications Tested/Suitable for anti-MCP1 antibody   

ELISA (EIA), Inhibition, Western Blot (WB)

 Application Notes for anti-MCP1 antibody    ELISA: 0.5-2 ug/ml
Inhibition: 4-6 ug/ml
WB: 0.1-0.2 ug/ml
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NCBI/Uniprot data below describe general gene information for MCP1. It may not necessarily be applicable to this product.
 NCBI GI #    545465
 NCBI GeneID    6347
 NCBI Accession #    AAB29926.1 [Other Products]
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 UniProt Primary Accession #    P13500 [Other Products]
 UniProt Secondary Accession #    Q9UDF3; B2R4V3 [Other Products]
 UniProt Related Accession #    P13500 [Other Products]
 Molecular Weight    8.6 kDa (predicted detection band MW)
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 NCBI Official Full Name    MCP-1
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 2
 NCBI Official Symbol    CCL2 [Similar Products]
 NCBI Official Synonym Symbols   
HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 2
 UniProt Protein Name    C-C motif chemokine 2
 UniProt Synonym Protein Names   
HC11; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte chemotactic protein 1; MCP-1; Monocyte secretory protein JE; Small-inducible cytokine A2
 Protein Family    MDM10-complementing protein
 UniProt Gene Name    CCL2 [Similar Products]
 UniProt Synonym Gene Names    MCP1; SCYA2; MCAF; MCP-1 [Similar Products]
 UniProt Entry Name    CCL2_HUMAN
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 NCBI Summary for MCP1    This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]
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 UniProt Comments for MCP1    CCL2: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q11.2-q12

Cellular Component: extracellular space; rough endoplasmic reticulum; perinuclear region of cytoplasm; endocytic vesicle; dendrite; extracellular region; synapse; perikaryon; nerve terminal

Molecular Function: heparin binding; chemokine activity; CCR2 chemokine receptor binding; receptor binding; protein kinase activity

Biological Process: maternal process involved in pregnancy; protein amino acid phosphorylation; response to antibiotic; monocyte chemotaxis; regulation of cell shape; cell surface receptor linked signal transduction; response to vitamin B3; transforming growth factor beta receptor signaling pathway; cellular homeostasis; negative regulation of neuron apoptosis; cell adhesion; neutrophil chemotaxis; organ regeneration; positive regulation of tumor necrosis factor production; response to amino acid stimulus; JAK-STAT cascade; G-protein signaling, coupled to cyclic nucleotide second messenger; organ morphogenesis; response to ethanol; unfolded protein response, activation of signaling protein activity; response to bacterium; cellular response to insulin stimulus; response to heat; response to mechanical stimulus; positive regulation of endothelial cell proliferation; response to activity; response to progesterone stimulus; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of collagen biosynthetic process; signal transduction; chemotaxis; positive regulation of synaptic transmission; positive regulation of cellular extravasation; lipopolysaccharide-mediated signaling pathway; protein kinase B signaling cascade; response to wounding; response to gamma radiation; angiogenesis; inflammatory response; lymphocyte chemotaxis; aging; unfolded protein response; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; cytoskeleton organization and biogenesis; viral genome replication; macrophage chemotaxis; humoral immune response; leukocyte migration during inflammatory response; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of leukocyte mediated cytotoxicity; cellular protein metabolic process; maternal process involved in parturition; response to hypoxia; positive regulation of T cell activation; vascular endothelial growth factor receptor signaling pathway; astrocyte cell migration

Disease: Neural Tube Defects; Mycobacterium Tuberculosis, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To
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 Research Articles on MCP1    1. Meta-analysis identifies association of rs833061 variant in the VEGFA gene and rs3917887 variant in the CCL2 gene as the most significant association with the risk of diabetic nephropathy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MCP1 antibodyPathways associated with anti-MCP1 antibody
 Reference Product  PubMed Publications
 TNF antibody  >2077 publications with MCP1 and TNF
 CCL5 antibody  >1428 publications with MCP1 and CCL5
 CCR2 antibody  >1292 publications with MCP1 and CCR2
 JUN antibody  >1291 publications with MCP1 and JUN
 CCR5 antibody  >340 publications with MCP1 and CCR5
 CCR1 antibody  >185 publications with MCP1 and CCR1
 CCR3 antibody  >103 publications with MCP1 and CCR3
 FOS antibody  >90 publications with MCP1 and FOS
 IL1B antibody  >73 publications with MCP1 and IL1B
 CCBP2 antibody  >6 publications with MCP1 and CCBP2
 Products by Pathway  Pathway Diagram
 ATF4 Activates Genes Pathway antibodies  ATF4 Activates Genes Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with anti-MCP1 antibodyOrgans/Tissues associated with anti-MCP1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4651 publications with MCP1 and Inflammation
 Necrosis Antibodies  >2696 publications with MCP1 and Necrosis
 Cardiovascular Diseases Antibodies  >1940 publications with MCP1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >1080 publications with MCP1 and Atherosclerosis
 Myocardial Ischemia Antibodies  >416 publications with MCP1 and Myocardial Ischemia
 Liver Diseases Antibodies  >380 publications with MCP1 and Liver Diseases
 Hypersensitivity Antibodies  >333 publications with MCP1 and Hypersensitivity
 Glomerulonephritis Antibodies  >296 publications with MCP1 and Glomerulonephritis
 Lung Injury Antibodies  >256 publications with MCP1 and Lung Injury
 Reperfusion Injury Antibodies  >215 publications with MCP1 and Reperfusion Injury
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5938 publications with MCP1 and Blood
 Vascular Antibodies  >2663 publications with MCP1 and Vascular
 Kidney Antibodies  >1214 publications with MCP1 and Kidney
 Lung Antibodies  >1135 publications with MCP1 and Lung
 Muscle Antibodies  >1082 publications with MCP1 and Muscle
 Brain Antibodies  >989 publications with MCP1 and Brain
 Bone Antibodies  >766 publications with MCP1 and Bone
 Liver Antibodies  >726 publications with MCP1 and Liver
 Heart Antibodies  >691 publications with MCP1 and Heart
 Bone Marrow Antibodies  >504 publications with MCP1 and Bone Marrow
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