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anti-SLC16A3 antibody :: Rabbit anti-Human MCT4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127546
Western Blot (WB)
Unit / Price
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MCT4 (SLC16A3), Polyclonal Antibody

★Popular Item★
 Also Known As   

MCT4 Polyclonal Antibody

 Product Synonym Names    SLC16A3; MCT4; Monocarboxylate transporter 4
 Product Gene Name   

anti-SLC16A3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603877
 3D Structure    ModBase 3D Structure for O15427
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Route    Synthetic Peptide
 Category    Primary antibody
 Immunogen    A synthetic peptide of human MCT4
 Calculated Molecular Weight    49kDa
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-SLC16A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SLC16A3 antibody

   Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions (2). However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis (2). In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell (1,2). This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate (1 -3).The MCT family consists of at least eight members, MCT 1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm (4). MCT1 is widely expressed and is the major form of MCT in tumor cells and erythrocytes (5,6). MCT2 is highly expressed in liver and testis, while MCT3 and MCT4 are predominantly expressed in skeletal muscle (7,8).
 Product Categories/Family for anti-SLC16A3 antibody    Polyclonal
 Applications Tested/Suitable for anti-SLC16A3 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-SLC16A3 antibody    WB: 1:200 - 1:500
IHC: 1:50 - 1:100
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 Western Blot (WB) of anti-SLC16A3 antibody    Western blot analysis of extracts of NCI-H460 cells, using SLC16A3 antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
anti-SLC16A3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SLC16A3. It may not necessarily be applicable to this product.
 NCBI GI #    6225705
 NCBI GeneID    9123
 NCBI Accession #    O15427.1 [Other Products]
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 UniProt Primary Accession #    O15427 [Other Products]
 UniProt Secondary Accession #    Q2M1P8; B3KXG8 [Other Products]
 UniProt Related Accession #    O15427 [Other Products]
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 NCBI Official Full Name    Monocarboxylate transporter 4
 NCBI Official Synonym Full Names    solute carrier family 16 (monocarboxylate transporter), member 3
 NCBI Official Symbol    SLC16A3 [Similar Products]
 NCBI Official Synonym Symbols   
MCT3; MCT4; MCT 3; MCT 4; MCT-3; MCT-4
[Similar Products]
 NCBI Protein Information    monocarboxylate transporter 4; monocarboxylate transporter 3; solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
 UniProt Protein Name    Monocarboxylate transporter 4
 UniProt Synonym Protein Names   
Solute carrier family 16 member 3
 Protein Family    Monocarboxylate transporter
 UniProt Gene Name    SLC16A3 [Similar Products]
 UniProt Synonym Gene Names    MCT4; MCT 4 [Similar Products]
 UniProt Entry Name    MOT4_HUMAN
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 NCBI Summary for SLC16A3    Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for SLC16A3    SLC16A3: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: nuclear membrane; membrane; integral to plasma membrane; plasma membrane; actin cytoskeleton

Molecular Function: monocarboxylic acid transmembrane transporter activity; symporter activity; lactate transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity

Biological Process: cellular metabolic process; monocarboxylic acid transport; pyruvate metabolic process; blood coagulation; leukocyte migration; transmembrane transport
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 Research Articles on SLC16A3    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SLC16A3 antibodyPathways associated with anti-SLC16A3 antibody
 Reference Product  PubMed Publications
 SLC2A1 antibody  >4 publications with SLC16A3 and SLC2A1
 BSG antibody  >4 publications with SLC16A3 and BSG
 SLC16A1 antibody  >3 publications with SLC16A3 and SLC16A1
 LDHA antibody  >2 publications with SLC16A3 and LDHA
 SLC16A8 antibody  >2 publications with SLC16A3 and SLC16A8
 Products by Pathway  Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Proton-coupled Monocarboxylate Transport Pathway antibodies  Proton-coupled Monocarboxylate Transport Pathway Diagram
 Pyruvate Metabolism Pathway antibodies  Pyruvate Metabolism Pathway Diagram
 Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway antibodies  Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
Diseases associated with anti-SLC16A3 antibodyOrgans/Tissues associated with anti-SLC16A3 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >3 publications with SLC16A3 and Kidney Diseases
 Ovarian Neoplasms Antibodies  >3 publications with SLC16A3 and Ovarian Neoplasms
 Liver Diseases Antibodies  >2 publications with SLC16A3 and Liver Diseases
 Breast Neoplasms Antibodies  >2 publications with SLC16A3 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with SLC16A3 and Neoplasm Metastasis
 Proteinuria Antibodies  >1 publications with SLC16A3 and Proteinuria
 Neoplasms, Experimental Antibodies  >1 publications with SLC16A3 and Neoplasms, Experimental
 Atrophy Antibodies  >1 publications with SLC16A3 and Atrophy
 Carcinoma, Hepatocellular Antibodies  >1 publications with SLC16A3 and Carcinoma, Hepatocellular
 Atherosclerosis Antibodies  >1 publications with SLC16A3 and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >12 publications with SLC16A3 and Muscle
 Eye Antibodies  >9 publications with SLC16A3 and Eye
 Blood Antibodies  >5 publications with SLC16A3 and Blood
 Kidney Antibodies  >5 publications with SLC16A3 and Kidney
 Brain Antibodies  >4 publications with SLC16A3 and Brain
 Vascular Antibodies  >4 publications with SLC16A3 and Vascular
 Liver Antibodies  >3 publications with SLC16A3 and Liver
 Heart Antibodies  >3 publications with SLC16A3 and Heart
 Bone Antibodies  >2 publications with SLC16A3 and Bone
 Embryonic Tissue Antibodies  >2 publications with SLC16A3 and Embryonic Tissue
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