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anti-Abcb1a antibody :: Rabbit MDR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9216837
Immunohistochemistry
Unit / Price
  DISCONTINUED
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MDR1 (Abcb1a), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Anti-MDR1 Polyclonal Antibody

 Product Synonym Names    Purified Rabbit Polyclonal Antibody (Pab); Pgp; Mdr3; P-gp; Pgy3; Abcb4; Evi32; Mdr1a; Pgy-3; mdr-3; Multidrug resistance protein 1A; ATP-binding cassette sub-family B member 1A; Multidrug resistance protein 3; P-glycoprotein 3; Abcb1a
 Product Gene Name   

anti-Abcb1a antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P21447
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Form/Format    0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
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 Antigen Source    KLH conjugated synthetic peptide derived from M MDR1
 Antigen Type    Synthetic Peptide
 Cellular Location    cell membrane; Multi-pass membrance protein.
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 Preparation and Storage    Shipped at 4 degree C, Store at -20 degree C (Avoid repeated freeze/thaw cycles).
 Other Notes    Small volumes of anti-Abcb1a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Abcb1a antibody

   Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
 Applications Tested/Suitable for anti-Abcb1a antibody   

Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-Abcb1a antibody    IHC-P: ~~1:100-1:500
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 Immunohistochemistry of anti-Abcb1a antibody    Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-MDR1/p-GP/CD243 Polyclonal Antibody (MBS9216837), Unconjugated 1:200 at 1:200, followed by conjugation to the secondary antibody and DAB staining
anti-Abcb1a antibody Immunohistochemistry (IHC) image
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NCBI/Uniprot data below describe general gene information for Abcb1a. It may not necessarily be applicable to this product.
 NCBI GI #    153791547
 NCBI GeneID    18671
 NCBI Accession #    NP_035206.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_011076.2 [Other Products]
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 UniProt Primary Accession #    P21447 [Other Products]
 UniProt Secondary Accession #    Q5I1Y5 [Other Products]
 UniProt Related Accession #    P21447 [Other Products]
 Molecular Weight    140647
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 NCBI Official Full Name    multidrug resistance protein 1A
 NCBI Official Synonym Full Names    ATP-binding cassette, sub-family B (MDR/TAP), member 1A
 NCBI Official Symbol    Abcb1a [Similar Products]
 NCBI Official Synonym Symbols   
Pgp; Mdr3; P-gp; Pgy3; Abcb4; Evi32; Mdr1a; Pgy-3; mdr-3
[Similar Products]
 NCBI Protein Information    multidrug resistance protein 1A
 UniProt Protein Name    Multidrug resistance protein 1A
 UniProt Synonym Protein Names   
ATP-binding cassette sub-family B member 1A; MDR1A; Multidrug resistance protein 3; P-glycoprotein 3
 Protein Family    Multidrug resistance protein
 UniProt Gene Name    Abcb1a [Similar Products]
 UniProt Synonym Gene Names    Abcb4; Mdr1a; Mdr3; Pgy-3; Pgy3 [Similar Products]
 UniProt Entry Name    MDR1A_MOUSE
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 NCBI Summary for Abcb1a    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Abcb1a    ABCB1: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8.

Protein type: Membrane protein, integral; Hydrolase; Transporter, ABC family; Membrane protein, multi-pass; EC 3.6.3.44; Transporter; Cell adhesion

Cellular Component: intercellular canaliculus; cell surface; membrane; apical part of cell; integral to membrane; plasma membrane

Molecular Function: hydrolase activity; ATPase activity, coupled to transmembrane movement of substances; ATPase activity; nucleotide binding; ATPase activity, coupled; ATP binding; xenobiotic-transporting ATPase activity

Biological Process: daunorubicin transport; hormone transport; drug transport; transport; drug export; multidrug transport; G2/M transition of mitotic cell cycle; transmembrane transport
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 Research Articles on Abcb1a    1. Mdr1a participates in the elimination of paraquat from the kidneys and protects against subsequent toxicity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Abcb1a antibodyPathways associated with anti-Abcb1a antibody
 Reference Product  PubMed Publications
 Slc22a3 antibody  >1 publications with Abcb1a and Slc22a3
 Nr1i2 antibody  >1 publications with Abcb1a and Nr1i2
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
Diseases associated with anti-Abcb1a antibodyOrgans/Tissues associated with anti-Abcb1a antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >11 publications with Abcb1a and Inflammation
 Liver Diseases Antibodies  >8 publications with Abcb1a and Liver Diseases
 Liver Neoplasms Antibodies  >8 publications with Abcb1a and Liver Neoplasms
 Nervous System Diseases Antibodies  >7 publications with Abcb1a and Nervous System Diseases
 Brain Diseases Antibodies  >7 publications with Abcb1a and Brain Diseases
 Necrosis Antibodies  >4 publications with Abcb1a and Necrosis
 Carcinoma, Hepatocellular Antibodies  >4 publications with Abcb1a and Carcinoma, Hepatocellular
 Hypertension Antibodies  >3 publications with Abcb1a and Hypertension
 Heart Diseases Antibodies  >3 publications with Abcb1a and Heart Diseases
 Weight Loss Antibodies  >2 publications with Abcb1a and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >62 publications with Abcb1a and Blood
 Brain Antibodies  >61 publications with Abcb1a and Brain
 Intestine Antibodies  >14 publications with Abcb1a and Intestine
 Embryonic Tissue Antibodies  >8 publications with Abcb1a and Embryonic Tissue
 Heart Antibodies  >7 publications with Abcb1a and Heart
 Eye Antibodies  >2 publications with Abcb1a and Eye
 Skin Antibodies  >1 publications with Abcb1a and Skin
 Thymus Antibodies  >1 publications with Abcb1a and Thymus
 Uterus Antibodies  >1 publications with Abcb1a and Uterus
 Mammary Gland Antibodies  >1 publications with Abcb1a and Mammary Gland
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