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anti-MEF2C antibody :: Rabbit anti-Human, Rat MEF2C Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS176264
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MEF2C, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-MEF2C antibody

 Product Synonym Names    Myocyte-specific enhancer factor 2C; myocyte enhancer factor 2C; C5DELq14.3 antibody; DEL5q14.3 antibody; MADS box transcription enhancer factor 2 polypeptide C(myocyte enhancer factor 2C) antibody; MEF2C antibody; MEF2C_HUMAN antibody; Myocyte enhancer factor 2C antibody; Myocyte specific enhancer factor 2C antibody; Myocyte-specific enhancer factor 2C antibody; OTTHUMP00000222409 antibody; Similar to MADS box transcription enhancer factor 2 polypeptide C antibody
 Product Gene Name   

anti-MEF2C antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 613443
 3D Structure    ModBase 3D Structure for Q06413
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Specificity    No cross reactivity with other proteins.
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human MEF2C (406-419aa SRYPQHTRHEAGRS), identical to the related rat sequence.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MEF2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MEF2C antibody

   Description: Rabbit IgG polyclonal antibody for Myocyte-specific enhancer factor 2C(MEF2C) detection. Tested with WB, IHC-P in Human, Rat.
Background: MEF2C(myocyte enhancer factor 2C) also called  MADS box transcription enhancer factor 2, polypeptide C, is a protein that in humans is encoded by the MEF2C gene. MEF2C is a transcription factor in the Mef2 family.MEF2C, however, is induced late during myogenic differentiation and has a strict tissue-specific pattern of expression not seen in MEF2A or MEF2B. By fluorescence in situ hybridization, the human MEF2C is mapped to chromosome 5q14, a region with homology of synteny to the mouse location.MEF2C may be involved with maintenance of the differentiated state. Both MEF2A and Mef2c programmed similar profiles of gene expression in the heart that included genes involved in extracellular matrix remodeling, ion handling, and metabolism. NCOA2 mediates the coactivation of MEF2C-dependent transcription through interaction with the MADS box domain of MEF2C. 
 Applications Tested/Suitable for anti-MEF2C antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-MEF2C antibody    Western Blot:
Concentration: 0.1-0.5ug/ml
Tested Species: Hu, Rat

Immunohistochemistry (Paraffin-embedded Section):
Concentration:0.5-1ug/ml
Tested Species: Hu, Rat
Antigen Retrieval: By Heat

Tested Species: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20 mins is required for the staining of formalin/paraffin sections. Other applications have not been tested Optimal dilutions should be determined by end users.
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 Immunohistochemistry (IHC) of anti-MEF2C antibody    Anti-MEF2C antibody, MBS176264, IHC(P)
IHC(P): Human Intestine Tissue
anti-MEF2C antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-MEF2C antibody    Anti-MEF2C antibody, MBS176264, Western blotting
Lane 1: Rat Testis Tissue Lysate
Lane 2: COLO320 Cell Lysate

anti-MEF2C antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MEF2C. It may not necessarily be applicable to this product.
 NCBI GI #    2500875
 NCBI GeneID    4208
 NCBI Accession #    Q06413.1 [Other Products]
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 UniProt Primary Accession #    Q06413 [Other Products]
 UniProt Secondary Accession #    C9JMZ0; D7F7N5; F8W7V7 [Other Products]
 UniProt Related Accession #    Q06413 [Other Products]
 Molecular Weight    50,242 Da
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 NCBI Official Full Name    Myocyte-specific enhancer factor 2C
 NCBI Official Synonym Full Names    myocyte enhancer factor 2C
 NCBI Official Symbol    MEF2C [Similar Products]
 NCBI Official Synonym Symbols   
DEL5q14.3; C5DELq14.3
[Similar Products]
 NCBI Protein Information    myocyte-specific enhancer factor 2C; MADS box transcription enhancer factor 2, polypeptide C
 UniProt Protein Name    Myocyte-specific enhancer factor 2C
 Protein Family    Myocyte-specific enhancer factor
 UniProt Gene Name    MEF2C [Similar Products]
 UniProt Entry Name    MEF2C_HUMAN
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 NCBI Summary for MEF2C    This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
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 UniProt Comments for MEF2C    MEF2C: transcription factor of the MADS family which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in myogenesis, neurogenesis and in the development of cortical architecture. Three splice-variant isoforms have been described.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 5q14.3

Cellular Component: nucleoplasm; protein complex; intracellular membrane-bound organelle; cytoplasm; nuclear speck; cytosol; nucleus

Molecular Function: protein binding; miRNA binding; transcription activator binding; DNA binding; AT DNA binding; protein heterodimerization activity; histone deacetylase binding; chromatin binding; transcription factor activity

Biological Process: cardiac muscle hypertrophy; muscle development; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; heart development; stress-activated MAPK cascade; regulation of neurotransmitter secretion; regulation of synaptic plasticity; toll-like receptor 3 signaling pathway; neuron differentiation; toll-like receptor 5 signaling pathway; positive regulation of MAP kinase activity; B cell receptor signaling pathway; regulation of neuron apoptosis; positive regulation of B cell proliferation; negative regulation of ossification; chondrocyte differentiation; negative regulation of neuron apoptosis; toll-like receptor 4 signaling pathway; positive regulation of cardiac muscle cell proliferation; endochondral ossification; nervous system development; skeletal muscle development; monocyte differentiation; response to virus; myotube differentiation; positive regulation of skeletal muscle development; muscle cell fate determination; toll-like receptor 2 signaling pathway; muscle cell differentiation; regulation of synaptogenesis; neuron development; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; transcription from RNA polymerase II promoter; B cell proliferation; regulation of synaptic transmission, glutamatergic; apoptosis; neuron migration; ventricular cardiac muscle cell differentiation; regulation of synaptic activity; palate development; negative regulation of transcription from RNA polymerase II promoter; toll-like receptor 10 signaling pathway; learning and/or memory; regulation of transcription, DNA-dependent; B cell homeostasis; melanocyte differentiation; regulation of megakaryocyte differentiation; germinal center formation; heart looping; neural crest cell differentiation; negative regulation of epithelial cell proliferation; blood vessel development; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; embryonic viscerocranium morphogenesis; positive regulation of bone mineralization; humoral immune response; regulation of germinal center formation; positive regulation of myoblast differentiation; MyD88-dependent toll-like receptor signaling pathway; osteoblast differentiation; positive regulation of osteoblast differentiation; neuron morphogenesis during differentiation; toll-like receptor signaling pathway; innate immune response; positive regulation of muscle cell differentiation; blood vessel remodeling; platelet formation; regulation of excitatory postsynaptic membrane potential; positive regulation of neuron differentiation

Disease: Mental Retardation, Autosomal Dominant 20
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 Research Articles on MEF2C    1. MEF2 regulatory network is disrupted in myotonic dystrophy cardiac tissue leading to altered expression of a large number of miRNA and mRNA targets.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MEF2C antibodyPathways associated with anti-MEF2C antibody
 Reference Product  PubMed Publications
 GATA4 antibody  >115 publications with MEF2C and GATA4
 NKX2-5 antibody  >108 publications with MEF2C and NKX2-5
 HDAC4 antibody  >23 publications with MEF2C and HDAC4
 MYOD1 antibody  >20 publications with MEF2C and MYOD1
 MYOG antibody  >14 publications with MEF2C and MYOG
 NCOA2 antibody  >3 publications with MEF2C and NCOA2
 EP300 antibody  >3 publications with MEF2C and EP300
 MAPK14 antibody  >2 publications with MEF2C and MAPK14
 SMAD2 antibody  >1 publications with MEF2C and SMAD2
 MAPK7 antibody  >1 publications with MEF2C and MAPK7
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 ERK/MAPK Targets Pathway antibodies  ERK/MAPK Targets Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
Diseases associated with anti-MEF2C antibodyOrgans/Tissues associated with anti-MEF2C antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >89 publications with MEF2C and Heart Diseases
 Nervous System Diseases Antibodies  >50 publications with MEF2C and Nervous System Diseases
 Intellectual Disability Antibodies  >24 publications with MEF2C and Intellectual Disability
 Brain Diseases Antibodies  >23 publications with MEF2C and Brain Diseases
 Disease Models, Animal Antibodies  >19 publications with MEF2C and Disease Models, Animal
 Fibrosis Antibodies  >18 publications with MEF2C and Fibrosis
 Epilepsy Antibodies  >14 publications with MEF2C and Epilepsy
 Inflammation Antibodies  >12 publications with MEF2C and Inflammation
 Necrosis Antibodies  >12 publications with MEF2C and Necrosis
 Atrophy Antibodies  >8 publications with MEF2C and Atrophy
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >362 publications with MEF2C and Muscle
 Heart Antibodies  >263 publications with MEF2C and Heart
 Embryonic Tissue Antibodies  >124 publications with MEF2C and Embryonic Tissue
 Brain Antibodies  >74 publications with MEF2C and Brain
 Vascular Antibodies  >57 publications with MEF2C and Vascular
 Blood Antibodies  >56 publications with MEF2C and Blood
 Bone Marrow Antibodies  >37 publications with MEF2C and Bone Marrow
 Nerve Antibodies  >19 publications with MEF2C and Nerve
 Connective Tissue Antibodies  >19 publications with MEF2C and Connective Tissue
 Skin Antibodies  >14 publications with MEF2C and Skin
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