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anti-MFAP5 antibody :: Rabbit MFAP5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9204084
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MFAP5, Polyclonal Antibody

★Popular Item★
 Also Known As   

MFAP5 Antibody (C-term)

 Product Synonym Names    Microfibrillar-associated protein 5; MFAP-5; MP25; Microfibril-associated glycoprotein 2; MAGP-2; MFAP5; MAGP2
 Product Gene Name   

anti-MFAP5 antibody

[Similar Products]
 Antibody/Peptide Pairs    MFAP5 peptide (MBS9226785) is used for blocking the activity of MFAP5 antibody (MBS9204084)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    133-160
 OMIM    601103
 3D Structure    ModBase 3D Structure for Q13361
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Clone Number    RB18639
 Host    Rabbit
 Species Reactivity    Human (Predicted Reactivity: Bovine, Mouse)
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 Specificity    This MFAP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-160 amino acids from the C-terminal region of human MFAP5.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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 Function    May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils (PubMed:8557636).
 Cellular Location    Secreted, extracellular space, extracellular matrix
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 Preparation and Storage    Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-MFAP5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MFAP5 antibody

   MFAP5 is a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. The protein lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs. The structural differences suggest that this protein has some functions that are distinct from those of MFAP2.
 Product Categories/Family for anti-MFAP5 antibody    Cancer; Signal Transduction
 Applications Tested/Suitable for anti-MFAP5 antibody   

Western Blot (WB), ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P), Flow Cytometry (FC/FACS)

 Application Notes for anti-MFAP5 antibody    WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
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 Western Blot (WB) of anti-MFAP5 antibody    Western blot analysis of MFAP5 antibody (C-term) in K562 cell line lysates (35ug/lane). MFAP5 (arrow) was detected using the purified Pab.
anti-MFAP5 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MFAP5 antibody    Formalin-fixed and paraffin-embedded human Skeletal muscle reacted with MFAP5 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-MFAP5 antibody Immunohistochemistry (IHC) (IHC) image
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 Flow Cytometry (FC/FACS) of anti-MFAP5 antibody    MFAP5 Antibody (C-term) flow cytometry analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-MFAP5 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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 Western Blot (WB) of anti-MFAP5 antibody    Western blot analysis of MFAP5 (arrow) using rabbit polyclonal MFAP5 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MFAP5 gene.
anti-MFAP5 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MFAP5. It may not necessarily be applicable to this product.
 NCBI GI #    4505089
 NCBI GeneID    8076
 NCBI Accession #    NP_003471.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003480.3 [Other Products]
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 UniProt Primary Accession #    Q13361 [Other Products]
 UniProt Secondary Accession #    Q7Z490; B0AZL6; D3DUV1 [Other Products]
 UniProt Related Accession #    Q13361 [Other Products]
 Molecular Weight    19612
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 NCBI Official Full Name    microfibrillar-associated protein 5 isoform a
 NCBI Official Synonym Full Names    microfibrillar associated protein 5
 NCBI Official Symbol    MFAP5 [Similar Products]
 NCBI Official Synonym Symbols   
AAT9; MP25; MAGP2; MAGP-2; MFAP-5
[Similar Products]
 NCBI Protein Information    microfibrillar-associated protein 5
 UniProt Protein Name    Microfibrillar-associated protein 5
 UniProt Synonym Protein Names   
MP25; Microfibril-associated glycoprotein 2; MAGP-2
 Protein Family    Microfibrillar-associated protein
 UniProt Gene Name    MFAP5 [Similar Products]
 UniProt Synonym Gene Names    MAGP2; MFAP-5; MAGP-2 [Similar Products]
 UniProt Entry Name    MFAP5_HUMAN
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 NCBI Summary for MFAP5    This gene encodes a 25-kD microfibril-associated glycoprotein which is a component of microfibrils of the extracellular matrix. The encoded protein promotes attachment of cells to microfibrils via alpha-V-beta-3 integrin. Deficiency of this gene in mice results in neutropenia. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
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 UniProt Comments for MFAP5    MFAP5: Component of the elastin-associated microfibrils. Belongs to the MFAP family.

Protein type: Secreted, signal peptide; Secreted; Extracellular matrix

Chromosomal Location of Human Ortholog: 12p13.1-p12.3

Cellular Component: microfibril; extracellular region

Molecular Function: extracellular matrix structural constituent

Biological Process: extracellular matrix organization and biogenesis; fibril organization and biogenesis

Disease: Aortic Aneurysm, Familial Thoracic 9
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Product References and Citations for anti-MFAP5 antibody

   Albig,A.R., Becenti,D.J. Microvasc. Res. 76 (1), 7-14 (2008)
Miyamoto,A., Lau,R. J. Biol. Chem. 281 (15), 10089-10097 (2006)
Penner,A.S., Rock,M.J. J. Biol. Chem. 277 (38), 35044-35049 (2002)
Hatzinikolas,G. J. Biol. Chem. 273 (45), 29309-29314 (1998)
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 Research Articles on MFAP5    1. Alteration of MAGP-2, a component of microfibrils and elastic fibers, appears as an initiating mechanism of inherited Thoracic aortic aneurysm and dissection (TAAD).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MFAP5 antibodyPathways associated with anti-MFAP5 antibody
 Reference Product  PubMed Publications
 FBLN2 antibody  >1 publications with MFAP5 and FBLN2
 FBLN1 antibody  >1 publications with MFAP5 and FBLN1
 FBN1 antibody  >1 publications with MFAP5 and FBN1
 Products by Pathway  Pathway Diagram
 , Pathway antibodies  , Pathway Diagram
 , Pathway antibodies  , Pathway Diagram
 , Pathway antibodies  , Pathway Diagram
 , Pathway antibodies  , Pathway Diagram
Diseases associated with anti-MFAP5 antibodyOrgans/Tissues associated with anti-MFAP5 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with MFAP5 and Inflammation
 Fetal Death Antibodies  >1 publications with MFAP5 and Fetal Death
 Insulin Resistance Antibodies  >1 publications with MFAP5 and Insulin Resistance
 Adenocarcinoma Antibodies  >1 publications with MFAP5 and Adenocarcinoma
 Fibrosis Antibodies  >1 publications with MFAP5 and Fibrosis
 Infertility, Male Antibodies  >1 publications with MFAP5 and Infertility, Male
 Weight Loss Antibodies  >1 publications with MFAP5 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >3 publications with MFAP5 and Adipose Tissue
 Connective Tissue Antibodies  >3 publications with MFAP5 and Connective Tissue
 Bone Antibodies  >3 publications with MFAP5 and Bone
 Vascular Antibodies  >3 publications with MFAP5 and Vascular
 Muscle Antibodies  >1 publications with MFAP5 and Muscle
 Lung Antibodies  >1 publications with MFAP5 and Lung
 Uterus Antibodies  >1 publications with MFAP5 and Uterus
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