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anti-MFI2 antibody :: Rabbit MFI2 / p97 / Melanotransferrin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241517
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MFI2 / p97 / Melanotransferrin, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human MFI2 / p97 / Melanotransferrin

 Product Synonym Names    Anti-MFI2 / p97 / Melanotransferrin Antibody (N-Terminus) IHC-plus; MFI2; Antigen p97; CD228; CD228 antigen; MAP97; Melanotransferrin; p97; Human MFI2; p97; Melanotransferrin
 Product Gene Name   

anti-MFI2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    155750
 3D Structure    ModBase 3D Structure for P08582
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Bat, Gibbon, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Rat
Predicted Reactivity: Bovine, Pig, Rabbit (at least 90% immunogen sequence identity)
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 Specificity    Human MFI2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 15 amino acid peptide from N-terminus of human MFI2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bat, Hamster, Elephant, Panda, Horse (100%); Bovine, Rabbit, Pig (93%).
 Immunogen Type    Synthetic peptide
 Immunogen    MFI2 / p97 / Melanotransferrin antibody was raised against synthetic 15 amino acid peptide from N-terminus of human MFI2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bat, Hamster, Elephant, Panda, Horse (100%); Bovine, Rabbit, Pig (93%); Chicken, Platypus (87%); Dog, Turkey, Medaka, Zebrafish (80%).
 Antigen Modification    N-Terminus
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-MFI2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MFI2 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-MFI2 antibody    IHC-P (15 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-MFI2 antibody    Anti-MFI2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-MFI2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-MFI2 antibody    Anti-MFI2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-MFI2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MFI2. It may not necessarily be applicable to this product.
 NCBI GI #    134244281
 NCBI GeneID    4241
 NCBI Accession #    NP_005920.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005929.5 [Other Products]
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 UniProt Primary Accession #    P08582 [Other Products]
 UniProt Secondary Accession #    Q9BQE2 [Other Products]
 UniProt Related Accession #    P08582 [Other Products]
 Molecular Weight    32,723 Da
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 NCBI Official Full Name    melanotransferrin isoform 1
 NCBI Official Synonym Full Names    antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
 NCBI Official Symbol    MFI2 [Similar Products]
 NCBI Official Synonym Symbols   
MTF1; CD228; MAP97
[Similar Products]
 NCBI Protein Information    melanotransferrin; membrane-bound transferrin-like protein; melanoma-associated antigen p97, isoform 2
 UniProt Protein Name    Melanotransferrin
 UniProt Synonym Protein Names   
Melanoma-associated antigen p97; CD_antigen: CD228
 UniProt Gene Name    MFI2 [Similar Products]
 UniProt Synonym Gene Names    MAP97 [Similar Products]
 UniProt Entry Name    TRFM_HUMAN
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 NCBI Summary for MFI2    The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MFI2    MFI2: Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. Belongs to the transferrin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 3q28-q29

Cellular Component: cell surface; anchored to plasma membrane; integral to plasma membrane

Molecular Function: protein binding; ferric iron binding; iron ion binding

Biological Process: cellular iron ion homeostasis; regulation of cell growth; regulation of cell proliferation
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 Research Articles on MFI2    1. PC3 tumors are sustained by a small number of tumor-initiating cells with stem-like characteristics, including strong self-renewal and pro-angiogenic capability and marked by the expression pattern FAM65Bhigh/MFI2low/LEF1low.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-MFI2 antibodyOrgans/Tissues associated with anti-MFI2 antibody
 Disease Name  Pubmed Publications
 Melanoma Antibodies  >4 publications with MFI2 and Melanoma
 Nervous System Diseases Antibodies  >1 publications with MFI2 and Nervous System Diseases
 Movement Disorders Antibodies  >1 publications with MFI2 and Movement Disorders
 Hemorrhage Antibodies  >1 publications with MFI2 and Hemorrhage
 Breast Neoplasms Antibodies  >1 publications with MFI2 and Breast Neoplasms
 Congenital Abnormalities Antibodies  >1 publications with MFI2 and Congenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with MFI2 and Bone
 Embryonic Tissue Antibodies  >1 publications with MFI2 and Embryonic Tissue
 Kidney Antibodies  >1 publications with MFI2 and Kidney
 Intestine Antibodies  >1 publications with MFI2 and Intestine
 Prostate Antibodies  >1 publications with MFI2 and Prostate
 Eye Antibodies  >1 publications with MFI2 and Eye
 Brain Antibodies  >1 publications with MFI2 and Brain
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