NP_001108089.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,878 Da
NCBI Official Full Name
alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NCBI Official Synonym Full Names
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
NCBI Official Synonym Symbols
GnTI; MGAT; GLCT1; GLYT1; GNT-1; GNT-I; GLCNAC-TI [Similar Products]
NCBI Protein Information
alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
UniProt Protein Name
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
UniProt Synonym Protein Names
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I; GNT-I; GlcNAc-T I
UniProt Synonym Gene Names
UniProt Entry Name
MGAT1_HUMAN
NCBI Summary for MGAT1
There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for MGAT1
MGAT1: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. Belongs to the glycosyltransferase 13 family.
Protein type: Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis; Transferase; EC 2.4.1.101
Chromosomal Location of Human Ortholog: 5q35
Cellular Component: Golgi membrane; membrane
Molecular Function: acetylglucosaminyltransferase activity; alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
Biological Process: carbohydrate metabolic process
Research Articles on MGAT1
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Pathways associated with anti-MGAT1 antibody
Diseases associated with anti-MGAT1 antibody
Organs/Tissues associated with anti-MGAT1 antibody
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