AAH39583.2
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
96,932 Da
NCBI Official Full Name
MGEA5 protein
NCBI Official Synonym Full Names
meningioma expressed antigen 5 (hyaluronidase)
NCBI Protein Information
protein O-GlcNAcase; N-acetyl-beta-D-glucosaminidase; N-acetyl-beta-glucosaminidase; beta-N-acetylglucosaminidase; beta-N-acetylhexosaminidase; beta-hexosaminidase; bifunctional protein NCOAT; hyaluronidase in meningioma; meningioma-expressed antigen 5; nuclear cytoplasmic O-GlcNAcase and acetyltransferase
UniProt Protein Name
Protein O-GlcNAcase
UniProt Synonym Protein Names
Beta-N-acetylglucosaminidase; Beta-N-acetylhexosaminidaseBeta-hexosaminidaseMeningioma-expressed antigen 5
UniProt Synonym Gene Names
UniProt Entry Name
OGA_HUMAN
NCBI Summary for MGEA5
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
UniProt Comments for MGEA5
OGA: Cleaves GlcNAc but not GalNAc from glycopeptides. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc. Possesses hyaluronidase activity. Acetylates 'Lys-8' of histone H4 and 'Lys-14' of histone H3. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.2.1.169; EC 3.2.1.52; Hydrolase; Acetyltransferase
Chromosomal Location of Human Ortholog: 10q24.1-q24.3
Cellular Component: membrane; cytosol; nucleus
Molecular Function: histone acetyltransferase activity; beta-N-acetylglucosaminidase activity; hyalurononglucosaminidase activity
Biological Process: positive regulation of DNA metabolic process; positive regulation of protein complex disassembly; dATP metabolic process; positive regulation of proteolysis; protein deglycosylation; N-acetylglucosamine metabolic process; positive regulation of insulin secretion; positive regulation of growth hormone secretion; positive regulation of glucose import; negative regulation of protein amino acid glycosylation; positive regulation of mitochondrial depolarization; positive regulation of cell killing; response to steroid hormone stimulus; histone acetylation; glycoprotein catabolic process; protein targeting to membrane; aging
Research Articles on MGEA5
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Products associated with anti-MGEA5 antibody
Pathways associated with anti-MGEA5 antibody
Diseases associated with anti-MGEA5 antibody
Organs/Tissues associated with anti-MGEA5 antibody
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