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anti-MLK3 antibody :: Rabbit MLK3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9386068
Western Blot (WB)
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MLK3, Polyclonal Antibody

★Popular Item★
 Also Known As   

MLK3 (Phospho-Thr277+Ser281) Antibody

 Product Gene Name   

anti-MLK3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS9386068 Technical Datasheet    Technical Datasheet PDF
 OMIM    U07747 mRNA
 3D Structure    ModBase 3D Structure for Q16584
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    MLK3 (Phospho-Thr277+Ser281) Ab detects endogenous levels of MLK3 only when phosphorylated at Thr277+Ser281
 Purity/Purification    The Ab is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and nonphospho-peptide affinity columns.
 Concentration    1.0mg/ml (lot specific)
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 Subcellular location    Cytoplasm > cytoskeleton > centrosome. Location is cell cycle dependent
 Immunogen    A synthesized peptide derived from human MLK3 (Phospho-Thr277+Ser281)
 Tissue Specifity    Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.
 Similarity    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
 Buffer    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Preparation and Storage    Store at -20C.Stable for 12 months from date of receipt
 Other Notes    Small volumes of anti-MLK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MLK3 antibody   

Western Blot (WB)

 Application Notes for anti-MLK3 antibody    WB 1:1000-3000
IHC 1:50-1:200
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 Western Blot (WB) of anti-MLK3 antibody    Western blot analysis of MLK3 (Phospho-Thr277+Ser281)using K562 whole cell lysates
anti-MLK3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MLK3. It may not necessarily be applicable to this product.
 NCBI GI #    4505195
 NCBI GeneID    4296
 NCBI Accession #    NP_002410.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002419.3 [Other Products]
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 UniProt Primary Accession #    Q16584 [Other Products]
 UniProt Secondary Accession #    Q53H00; Q59F06; Q6P2G4; B4DS76 [Other Products]
 UniProt Related Accession #    Q16584 [Other Products]
 Molecular Weight    92 KD
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 NCBI Official Full Name    mitogen-activated protein kinase kinase kinase 11
 NCBI Official Synonym Full Names    mitogen-activated protein kinase kinase kinase 11
 NCBI Official Symbol    MAP3K11 [Similar Products]
 NCBI Official Synonym Symbols   
MLK3; PTK1; SPRK; MLK-3; MEKK11
[Similar Products]
 NCBI Protein Information    mitogen-activated protein kinase kinase kinase 11
 UniProt Protein Name    Mitogen-activated protein kinase kinase kinase 11
 UniProt Synonym Protein Names   
Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase
 UniProt Gene Name    MAP3K11 [Similar Products]
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 NCBI Summary for MLK3    The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MLK3    MLK3: a TKL kinase of the MLK family. Has an amino-terminal SH3 domain followed by the kinase domain, two leucine zipper domains, a cdc42/Rac1 binding (CRIB) domain and several other domains/motifs at the carboxy-terminal region. Phosphorylates IkappaB and activates SEK1 and MKK7.

Protein type: EC 2.7.11.25; Kinase, protein; MLK family; MLK subfamily; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: centrosome; cytoplasm; membrane; microtubule

Molecular Function: identical protein binding; JUN kinase kinase kinase activity; mitogen-activated protein kinase kinase kinase binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity

Biological Process: activation of JNK activity; activation of MAPK activity; cell proliferation; JNK cascade; microtubule-based process; positive regulation of apoptosis; positive regulation of JNK activity; positive regulation of JNK cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation
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 Research Articles on MLK3    1. Increased expression of MAP3K11 is associated with esophageal cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MLK3 antibodyPathways associated with anti-MLK3 antibody
 Reference Product  PubMed Publications
 MAP3K1 antibody  >1 publications with MLK3 and MAP3K1
 Products by Pathway  Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 IFN-gamma Pathway antibodies  IFN-gamma Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 RAC1 Signaling Pathway antibodies  RAC1 Signaling Pathway Diagram
 Reelin Signaling Pathway antibodies  Reelin Signaling Pathway Diagram
Diseases associated with anti-MLK3 antibodyOrgans/Tissues associated with anti-MLK3 antibody
 Disease Name  Pubmed Publications
 Hearing Loss Antibodies  >1 publications with MLK3 and Hearing Loss
 Nervous System Diseases Antibodies  >1 publications with MLK3 and Nervous System Diseases
 Immune System Diseases Antibodies  >1 publications with MLK3 and Immune System Diseases
 Breast Neoplasms Antibodies  >1 publications with MLK3 and Breast Neoplasms
 Inflammation Antibodies  >1 publications with MLK3 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >3 publications with MLK3 and Testis
 Blood Antibodies  >1 publications with MLK3 and Blood
 Adrenal Gland Antibodies  >1 publications with MLK3 and Adrenal Gland
 Uterus Antibodies  >1 publications with MLK3 and Uterus
 Prostate Antibodies  >1 publications with MLK3 and Prostate
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