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DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-MLKL antibody :: Rabbit anti-Human MLKL Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2535095
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MLKL, Polyclonal Antibody

★Popular Item★
 Also Known As   

MLKL Polyclonal Antibody

 Product Synonym Names    MLKL; Mixed lineage kinase domain-like protein
 Product Gene Name   

anti-MLKL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    615153
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the N-terminal region of human MLKL.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-165025
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MLKL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-MLKL antibody    Cancer
 Applications Tested/Suitable for anti-MLKL antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-MLKL antibody    WB: 1:500-1:2000, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-MLKL antibody    Western Blot analysis of various cells using MLKL Polyclonal Antibody at dilution of 1:500.
anti-MLKL antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MLKL. It may not necessarily be applicable to this product.
 NCBI GI #    215820622
 NCBI GeneID    197259
 NCBI Accession #    NP_001135969.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001142497.2 [Other Products]
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 UniProt Secondary Accession #    Q8N6V0; A6NCE4 [Other Products]
 UniProt Related Accession #    Q8NB16 [Other Products]
 Molecular Weight    Calculated MW: 54
Observed MW: 55
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 NCBI Official Full Name    mixed lineage kinase domain-like protein isoform 2
 NCBI Official Synonym Full Names    mixed lineage kinase domain-like
 NCBI Official Symbol    MLKL [Similar Products]
 NCBI Official Synonym Symbols   
hMLKL
[Similar Products]
 NCBI Protein Information    mixed lineage kinase domain-like protein
 UniProt Protein Name    Mixed lineage kinase domain-like protein
 Protein Family    Mixed lineage kinase domain-like protein
 UniProt Gene Name    MLKL [Similar Products]
 UniProt Synonym Gene Names    hMLKL [Similar Products]
 UniProt Entry Name    MLKL_HUMAN
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 NCBI Summary for MLKL    This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
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 UniProt Comments for MLKL    MLKL: Belongs to the protein kinase superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; TKL-Unique family

Chromosomal Location of Human Ortholog: 16q23.1

Cellular Component: cytoplasm; cytosol; plasma membrane

Molecular Function: ATP binding; protein binding; protein complex binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity

Biological Process: programmed cell death; protein amino acid phosphorylation
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 Research Articles on MLKL    1. These data reveal a potential role for RIPK3 as a suppressor of MLKL activation and indicate that phosphorylation can fine-tune the ability of MLKL to induce necroptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MLKL antibodyPathways associated with anti-MLKL antibody
 Reference Product  PubMed Publications
 RIPK3 antibody  >94 publications with MLKL and RIPK3
 PGAM5 antibody  >10 publications with MLKL and PGAM5
 Products by Pathway  Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Programmed Cell Death Pathway antibodies  Programmed Cell Death Pathway Diagram
 RIPK1-mediated Regulated Necrosis Pathway antibodies  RIPK1-mediated Regulated Necrosis Pathway Diagram
 Regulated Necrosis Pathway antibodies  Regulated Necrosis Pathway Diagram
 TNF Signaling Pathway antibodies  TNF Signaling Pathway Diagram
 TNF Signaling Pathway antibodies  TNF Signaling Pathway Diagram
Diseases associated with anti-MLKL antibodyOrgans/Tissues associated with anti-MLKL antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >113 publications with MLKL and Necrosis
 Inflammation Antibodies  >45 publications with MLKL and Inflammation
 Liver Diseases Antibodies  >8 publications with MLKL and Liver Diseases
 Disease Models, Animal Antibodies  >7 publications with MLKL and Disease Models, Animal
 Kidney Diseases Antibodies  >5 publications with MLKL and Kidney Diseases
 Drug-Induced Liver Injury Antibodies  >4 publications with MLKL and Drug-Induced Liver Injury
 Drug-Related Side Effects and Adverse Reactions Antibodies  >3 publications with MLKL and Drug-Related Side Effects and Adverse Reactions
 Fibrosis Antibodies  >3 publications with MLKL and Fibrosis
 Nervous System Diseases Antibodies  >3 publications with MLKL and Nervous System Diseases
 Fatty Liver Antibodies  >2 publications with MLKL and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with MLKL and Brain
 Liver Antibodies  >11 publications with MLKL and Liver
 Heart Antibodies  >7 publications with MLKL and Heart
 Blood Antibodies  >7 publications with MLKL and Blood
 Kidney Antibodies  >7 publications with MLKL and Kidney
 Lung Antibodies  >5 publications with MLKL and Lung
 Bone Antibodies  >3 publications with MLKL and Bone
 Intestine Antibodies  >3 publications with MLKL and Intestine
 Bone Marrow Antibodies  >2 publications with MLKL and Bone Marrow
 Spleen Antibodies  >1 publications with MLKL and Spleen
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