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anti-MLLT10 antibody :: Rabbit anti-Human MLLT10 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241049
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MLLT10, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human MLLT10

 Product Synonym Names    Anti-MLLT10 Antibody (aa1013-1027) IHC-plus; MLLT10; AF10; Protein AF-10; Type I AF10 protein; Type III AF10 protein; Translocated to; 10; Type IV AF10 protein; Human MLLT10
 Product Gene Name   

anti-MLLT10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602409
 3D Structure    ModBase 3D Structure for P55197
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Amino acids 1013 to 1027 of human MLLT10
 Purity/Purification    Protein G Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human MLLT10 / AF10.
 Immunogen Type    Synthetic peptide
 Immunogen    MLLT10 antibody was raised against synthetic peptide from human MLLT10 / AF10.
 Antigen Modification    aa1013-1027
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-MLLT10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MLLT10 antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-MLLT10 antibody    ELISA (1:000 - 1:1000), IHC-P (5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-MLLT10 antibody    Anti-MLLT10 / AF10 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-MLLT10 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MLLT10. It may not necessarily be applicable to this product.
 NCBI GI #    4757726
 NCBI GeneID    8028
 NCBI Accession #    NP_004632.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004641.3 [Other Products]
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 UniProt Primary Accession #    P55197 [Other Products]
 UniProt Secondary Accession #    Q5JT37; Q5VX90; Q66K63; B1ANA8 [Other Products]
 UniProt Related Accession #    P55197 [Other Products]
 Molecular Weight    20,047 Da
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 NCBI Official Full Name    protein AF-10 isoform a
 NCBI Official Synonym Full Names    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
 NCBI Official Symbol    MLLT10 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    protein AF-10; type I AF10 protein; type IV AF10 protein; type III AF10 protein; ALL1-fused gene from chromosome 10 protein
 UniProt Protein Name    Protein AF-10
 UniProt Synonym Protein Names   
ALL1-fused gene from chromosome 10 protein
 Protein Family    Protein
 UniProt Gene Name    MLLT10 [Similar Products]
 UniProt Synonym Gene Names    AF10 [Similar Products]
 UniProt Entry Name    AF10_HUMAN
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 NCBI Summary for MLLT10    This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
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 UniProt Comments for MLLT10    MLLT10: Probably involved in transcriptional regulation. In vitro or as fusion protein with MLL has transactivation activity. Binds to cruciform DNA. A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with MLL/HRX. The result is a rogue activator protein. A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 10p12

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: protein binding; DNA binding; zinc ion binding; transcription factor activity

Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter

Disease: Leukemia, Acute Myeloid
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 Research Articles on MLLT10    1. detection of PICALM-MLLT10 fusion transcript occurs in 7% of children with T-lineage ALL and is not associated with a poorer outcome for patients treated with contemporary, intensive chemotherapy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MLLT10 antibodyDiseases associated with anti-MLLT10 antibody
 Reference Product  PubMed Publications
 MLLT3 antibody  >7 publications with MLLT10 and MLLT3
 DOT1L antibody  >7 publications with MLLT10 and DOT1L
 MLLT1 antibody  >5 publications with MLLT10 and MLLT1
 YEATS4 antibody  >3 publications with MLLT10 and YEATS4
 Disease Name  Pubmed Publications
 Leukemia, Myeloid, Acute Antibodies  >51 publications with MLLT10 and Leukemia, Myeloid, Acute
 Central Nervous System Diseases Antibodies  >2 publications with MLLT10 and Central Nervous System Diseases
 Meningioma Antibodies  >2 publications with MLLT10 and Meningioma
 Recurrence Antibodies  >1 publications with MLLT10 and Recurrence
 Brain Diseases Antibodies  >1 publications with MLLT10 and Brain Diseases
 Neoplasm Metastasis Antibodies  >1 publications with MLLT10 and Neoplasm Metastasis
Organs/Tissues associated with anti-MLLT10 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >19 publications with MLLT10 and Bone
 Blood Antibodies  >16 publications with MLLT10 and Blood
 Nerve Antibodies  >5 publications with MLLT10 and Nerve
 Testis Antibodies  >5 publications with MLLT10 and Testis
 Muscle Antibodies  >3 publications with MLLT10 and Muscle
 Brain Antibodies  >3 publications with MLLT10 and Brain
 Prostate Antibodies  >1 publications with MLLT10 and Prostate
 Thymus Antibodies  >1 publications with MLLT10 and Thymus
 Eye Antibodies  >1 publications with MLLT10 and Eye
 Placenta Antibodies  >1 publications with MLLT10 and Placenta
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