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anti-MLYCD antibody :: Rabbit anti-Human MLYCD Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7048672
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MLYCD, Polyclonal Antibody

★Popular Item★
 Also Known As   

MLYCD Antibody

 Product Synonym Names    Malonyl-CoA decarboxylase; mitochondrial; MLYCD
 Product Gene Name   

anti-MLYCD antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF097832 mRNA
 3D Structure    ModBase 3D Structure for O95822
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Malonyl-CoA decarboxylase, mitochondrial protein (40-493AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MLYCD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MLYCD antibody

   Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation.
 Applications Tested/Suitable for anti-MLYCD antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-MLYCD antibody    WB: 1: 2000-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Western Blot (WB) of anti-MLYCD antibody    Western Blot
Positive WB detected in:HEK293 whole cell lysate
All lanes: MLYCD antibody at 2.7ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 56,51 kDa
Observed band size: 56 kDa

anti-MLYCD antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MLYCD antibody    Immunohistochemistry of paraffin-embedded human heart tissue using MBS7048672 at dilution of 1:100
anti-MLYCD antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-MLYCD antibody    Immunofluorescent analysis of HepG2 cells using MBS7048672 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-MLYCD antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MLYCD. It may not necessarily be applicable to this product.
 NCBI GI #    110349750
 NCBI GeneID    23417
 NCBI Accession #    NP_036345.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_012213.2 [Other Products]
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 UniProt Primary Accession #    O95822 [Other Products]
 UniProt Secondary Accession #    Q9UNU5; Q9Y3F2 [Other Products]
 UniProt Related Accession #    O95822 [Other Products]
 Molecular Weight    50,946 Da
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 NCBI Official Full Name    malonyl-CoA decarboxylase, mitochondrial
 NCBI Official Synonym Full Names    malonyl-CoA decarboxylase
 NCBI Official Symbol    MLYCD [Similar Products]
 NCBI Official Synonym Symbols   
MCD
[Similar Products]
 NCBI Protein Information    malonyl-CoA decarboxylase, mitochondrial
 UniProt Protein Name    Malonyl-CoA decarboxylase, mitochondrial
 Protein Family    Malonyl-CoA decarboxylase
 UniProt Gene Name    MLYCD [Similar Products]
 UniProt Synonym Gene Names    MCD [Similar Products]
 UniProt Entry Name    DCMC_HUMAN
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 NCBI Summary for MLYCD    The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MLYCD    MLYCD: Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Defects in MLYCD are the cause of malonyl-CoA decarboxylase deficiency (MLYCD deficiency). MLYCD deficiency is an autosomal recessive disease characterized by abdominal pain, chronic constipation, episodic vomiting, metabolic acidosis and malonic aciduria.

Protein type: Carbohydrate Metabolism - propanoate; EC 4.1.1.9; Lyase; Other Amino Acids Metabolism - beta-alanine

Chromosomal Location of Human Ortholog: 16q24

Cellular Component: cytoplasm; mitochondrial matrix; mitochondrion; peroxisomal matrix; peroxisome

Molecular Function: malonyl-CoA decarboxylase activity; receptor binding

Biological Process: acetyl-CoA biosynthetic process; acyl-CoA metabolic process; fatty acid biosynthetic process; positive regulation of fatty acid oxidation

Disease: Malonyl-coa Decarboxylase Deficiency
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 Research Articles on MLYCD    1. Our result expands the phenotype of malonyl-CoA decarboxylase deficiency and suggests attentions should be paid to the mild form of disorders, for example, malonyl-CoA decarboxylase deficiency, which usually present a severe disease course.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MLYCD antibodyPathways associated with anti-MLYCD antibody
 Reference Product  PubMed Publications
 FASN antibody  >1 publications with MLYCD and FASN
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Peroxisomal Lipid Metabolism Pathway antibodies  Peroxisomal Lipid Metabolism Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Propanoate Metabolism Pathway antibodies  Propanoate Metabolism Pathway Diagram
 Propanoate Metabolism Pathway antibodies  Propanoate Metabolism Pathway Diagram
Diseases associated with anti-MLYCD antibodyOrgans/Tissues associated with anti-MLYCD antibody
 Disease Name  Pubmed Publications
 Malonic aciduria Antibodies  >9 publications with MLYCD and Malonic aciduria
 Heart Diseases Antibodies  >4 publications with MLYCD and Heart Diseases
 Cardiovascular Diseases Antibodies  >4 publications with MLYCD and Cardiovascular Diseases
 Liver Diseases Antibodies  >3 publications with MLYCD and Liver Diseases
 Fatty Liver Antibodies  >3 publications with MLYCD and Fatty Liver
 Weight Gain Antibodies  >2 publications with MLYCD and Weight Gain
 Insulin Resistance Antibodies  >2 publications with MLYCD and Insulin Resistance
 Non-alcoholic Fatty Liver Disease Antibodies  >1 publications with MLYCD and Non-alcoholic Fatty Liver Disease
 Hyperlipidemias Antibodies  >1 publications with MLYCD and Hyperlipidemias
 Dyslipidemias Antibodies  >1 publications with MLYCD and Dyslipidemias
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with MLYCD and Blood
 Brain Antibodies  >5 publications with MLYCD and Brain
 Heart Antibodies  >4 publications with MLYCD and Heart
 Liver Antibodies  >3 publications with MLYCD and Liver
 Skin Antibodies  >1 publications with MLYCD and Skin
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