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anti-MMP1 antibody :: Rabbit anti-Human MMP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6010248
Test Data
Unit / Price
0.25 mL  /  $695 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MMP1, Polyclonal Antibody

★Popular Item★
 Also Known As   

MMP1, CT (Interstitial Collagenase, Fibroblast Collagenase, Matrix Metalloproteinase-1, MMP-1, CLG)

 Product Synonym Names    Anti -MMP1, CT (Interstitial Collagenase, Fibroblast Collagenase, Matrix Metalloproteinase-1, MMP-1, CLG)
 Product Gene Name   

anti-MMP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (102660641..102668966, complement). Location: 11q22.3
 OMIM    120353
 3D Structure    ModBase 3D Structure for P03956
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human MMP1.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4, BSA, sodium azide.
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 Immunogen    Synthetic peptide corresponding to the C-terminal of human MMP-1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-MMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MMP1 antibody

   MMP1 is a Metallopeptidase M10A type protease. MMP1, also known as collagenase, is a secreted protein. Collagenase is the only enzyme able to initiate breakdown of the interstitial collagens, types I, II, and III. The fact that the collagens are the most abundant proteins in the body means that collagenase plays a key role in the remodeling that occurs constantly in both normal and diseased conditions.
 Product Categories/Family for anti-MMP1 antibody    Antibodies; Abs to Matrix Metalloproteinases
 Applications Tested/Suitable for anti-MMP1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-MMP1 antibody    Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 1:50
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 Test Data of anti-MMP1 antibody    Human Skeletal Muscle: Formalin-Fixed, Paraffin-Emdedded (FFPE)
anti-MMP1 antibody Test Data image
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NCBI/Uniprot data below describe general gene information for MMP1. It may not necessarily be applicable to this product.
 NCBI GI #    15341877
 NCBI GeneID    4312
 NCBI Accession #    AAH13118.1 [Other Products]
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 UniProt Primary Accession #    P03956 [Other Products]
 UniProt Secondary Accession #    P08156 [Other Products]
 UniProt Related Accession #    P03956 [Other Products]
 Molecular Weight    54,007 Da [Similar Products]
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 NCBI Official Full Name    MMP1 protein, partial
 NCBI Official Synonym Full Names    matrix metallopeptidase 1 (interstitial collagenase)
 NCBI Official Symbol    MMP1 [Similar Products]
 NCBI Official Synonym Symbols   
CLG; CLGN
[Similar Products]
 NCBI Protein Information    interstitial collagenase; fibroblast collagenase; matrix metalloprotease 1; matrix metalloproteinase 1
 UniProt Protein Name    Interstitial collagenase
 UniProt Synonym Protein Names   
Fibroblast collagenase; Matrix metalloproteinase-1
 Protein Family    Interstitial collagenase
 UniProt Gene Name    MMP1 [Similar Products]
 UniProt Synonym Gene Names    CLG; MMP-1 [Similar Products]
 UniProt Entry Name    MMP1_HUMAN
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 NCBI Summary for MMP1    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
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 UniProt Comments for MMP1    MMP1: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. Belongs to the peptidase M10A family.

Protein type: Secreted, signal peptide; Secreted; Protease; Motility/polarity/chemotaxis; EC 3.4.24.7

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: proteinaceous extracellular matrix; extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity; endopeptidase activity; calcium ion binding

Biological Process: collagen catabolic process; positive regulation of protein oligomerization; extracellular matrix disassembly; extracellular matrix organization and biogenesis; cellular protein metabolic process; viral reproduction; proteolysis; blood coagulation; leukocyte migration

Disease: Epidermolysis Bullosa Dystrophica, Autosomal Recessive; Pulmonary Disease, Chronic Obstructive
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 Research Articles on MMP1    1. MMP-1 g.-1607dupG polymorphism was associated with chronic periodontitis, especially the severity of the disease condition.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MMP1 antibodyPathways associated with anti-MMP1 antibody
 Reference Product  PubMed Publications
 JUN antibody  >119 publications with MMP1 and JUN
 TIMP1 antibody  >113 publications with MMP1 and TIMP1
 MMP7 antibody  >50 publications with MMP1 and MMP7
 FOS antibody  >23 publications with MMP1 and FOS
 ETS1 antibody  >20 publications with MMP1 and ETS1
 BSG antibody  >4 publications with MMP1 and BSG
 IGFBP3 antibody  >2 publications with MMP1 and IGFBP3
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Degradation Of Collagen Pathway antibodies  Degradation Of Collagen Pathway Diagram
 Degradation Of Collagen Pathway antibodies  Degradation Of Collagen Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
Diseases associated with anti-MMP1 antibodyOrgans/Tissues associated with anti-MMP1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >244 publications with MMP1 and Neoplasms
 Inflammation Antibodies  >100 publications with MMP1 and Inflammation
 Cardiovascular Diseases Antibodies  >70 publications with MMP1 and Cardiovascular Diseases
 Neoplasm Invasiveness Antibodies  >70 publications with MMP1 and Neoplasm Invasiveness
 Lung Diseases Antibodies  >65 publications with MMP1 and Lung Diseases
 Necrosis Antibodies  >65 publications with MMP1 and Necrosis
 Neoplasm Metastasis Antibodies  >54 publications with MMP1 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >49 publications with MMP1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >38 publications with MMP1 and Lung Neoplasms
 Heart Diseases Antibodies  >31 publications with MMP1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >121 publications with MMP1 and Blood
 Skin Antibodies  >115 publications with MMP1 and Skin
 Lung Antibodies  >90 publications with MMP1 and Lung
 Vascular Antibodies  >78 publications with MMP1 and Vascular
 Bone Antibodies  >74 publications with MMP1 and Bone
 Connective Tissue Antibodies  >70 publications with MMP1 and Connective Tissue
 Muscle Antibodies  >44 publications with MMP1 and Muscle
 Liver Antibodies  >30 publications with MMP1 and Liver
 Embryonic Tissue Antibodies  >27 publications with MMP1 and Embryonic Tissue
 Eye Antibodies  >26 publications with MMP1 and Eye
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