NP_002417.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
macrophage metalloelastase preproprotein
NCBI Official Synonym Full Names
matrix metallopeptidase 12
NCBI Protein Information
macrophage metalloelastase
UniProt Protein Name
Macrophage metalloelastase
UniProt Synonym Protein Names
Macrophage elastase; ME; hME; Matrix metalloproteinase-12; MMP-12
UniProt Synonym Gene Names
UniProt Entry Name
MMP12_HUMAN
NCBI Summary for MMP12
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]
UniProt Comments for MMP12
MMP12: May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. Belongs to the peptidase M10A family.
Protein type: Secreted; EC 3.4.24.65; Protease; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q22.3
Cellular Component: extracellular region; proteinaceous extracellular matrix
Molecular Function: calcium ion binding; endopeptidase activity; metalloendopeptidase activity; serine-type endopeptidase activity; zinc ion binding
Biological Process: collagen catabolic process; extracellular matrix disassembly; positive regulation of epithelial cell proliferation involved in wound healing; proteolysis; response to drug; response to organic cyclic substance; wound healing, spreading of epidermal cells
Research Articles on MMP12
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Pathways associated with anti-MMP12 antibody
Diseases associated with anti-MMP12 antibody
Organs/Tissues associated with anti-MMP12 antibody
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